Article
Plant Sciences
Xinlu Li, Jianfeng Chen, Wennuo Feng, Chao Wang, Minyu Chen, Yifan Li, Jinghong Chen, Xinwei Liu, Qiong Liu, Jing Tian
Summary: This study found that berberine (BBR) can alleviate iron accumulation and ferroptosis in the brains of 3xTg-AD model mice by inhibiting iron levels and iron death. It partially protects against RSL3-induced ferroptosis through the activation of the Nrf2 signaling pathway.
Review
Neurosciences
Yingying Ji, Kai Zheng, Shiming Li, Caili Ren, Ying Shen, Lin Tian, Haohao Zhu, Zhenhe Zhou, Ying Jiang
Summary: Ferroptosis, as a newly discovered form of cell death, plays a key role in the occurrence and development of neurodegenerative diseases. However, the underlying mechanism of ferroptosis in these diseases remains unclear, and further research is needed to explore its therapeutic potential.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Miaomiao Wang, Gan Tang, Congfa Zhou, Hongmin Guo, Zihui Hu, Qixing Hu, Guilin Li
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic neuroinflammation, amyloid beta-protein deposition, and hyperphosphorylated tau protein. Neuroinflammation and microglial activation play significant roles in AD, contributing to neuronal dysfunction and disease progression. Ferroptosis, an iron-dependent form of cell death, accelerates AD by promoting abnormal microglial activation and neuronal dysfunction. Iron dysregulation and neuronal ferroptosis aggravate neuroinflammation and abnormal microglial activation, creating a vicious cycle. This review explores the relationship between ferroptosis, microglia, and AD, emphasizing the role of ferroptosis in chronic neuroinflammation and providing new insights for potential therapeutic targets.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Yuan Zhang, Man Wang, Wenguang Chang
Summary: Alzheimer's disease, the most common type of senile dementia, has been found to be closely related to iron dysregulation and the induction of ferroptosis. Iron metabolism imbalance and dysfunction of the endogenous antioxidant systems contribute to the development of AD, and ferroptosis mediated by NCOA4-driven ferritinophagy accelerates the pathological process. NRF2 also plays an important role in regulating iron-dependent programmed cell death and the development of AD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Linyu Wu, Xiaohui Xian, Zixuan Tan, Fang Dong, Guangyu Xu, Min Zhang, Feng Zhang
Summary: Cell death, particularly the novel form called ferroptosis, plays a common role in the development of Alzheimer's disease (AD). Ferroptosis is an iron-regulated cell death mechanism identified in AD clinical samples, characterized by specific morphological changes, iron-dependent aggregation of reactive oxygen species and lipid peroxides, loss of glutathione and inactivation of glutathione peroxidase 4. This article reviews the potential role of ferroptosis in AD, including its involvement in iron metabolism, lipid metabolism, and redox homeostasis, as well as potential therapies targeting ferroptosis for AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Geriatrics & Gerontology
Feixue Wang, Jiandong Wang, Ying Shen, Hao Li, Wolf-Dieter Rausch, Xiaobo Huang
Summary: Iron plays a crucial role in the human body, but its accumulation in the brain is associated with cognitive decline in Alzheimer's disease. Abnormal iron metabolism leads to iron deposition and promotes the progression of Alzheimer's disease. Furthermore, iron deposition can trigger iron-mediated cell death and result in neuronal loss. Therefore, targeting iron metabolism could be a promising therapeutic approach for Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Md. Jakaria, Abdel Ali Belaidi, Ashley I. Bush, Scott Ayton
Summary: Alzheimer's disease, the most prevalent form of dementia, has a complex pathophysiology that is not fully understood. While beta-amyloid plaque and neurofibrillary tangles define the disease's pathology, the mechanism of neurodegeneration remains uncertain. Ferroptosis, an iron-mediated programmed cell death mechanism, has been observed in clinical AD samples, suggesting its implication in the pathogenesis of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Neurosciences
Guimei Zhang, Yaru Zhang, Yanxin Shen, Yongchun Wang, Meng Zhao, Li Sun
Summary: Alzheimer's disease is the most common cause of dementia, but the exact mechanism is still unclear. Recent research has shown that iron metabolism, lipid peroxidation, and oxidative stress play vital roles in the pathogenesis of AD, and the iron-dependent cell death known as ferroptosis may be involved in neurological disorders, including AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Medicine, Research & Experimental
Dickson Kofi Wiredu Ocansey, Jintao Yuan, Zhiping Wei, Fei Mao, Zhaoyang Zhang
Summary: Ferroptosis is a regulated form of cell death characterized by iron accumulation, lipid peroxidation, and excessive reactive oxygen species production. It plays a role in the development of inflammatory bowel disease (IBD) and could be a potential therapeutic target. Inhibiting the characteristic features of ferroptosis has shown promising outcomes in relieving IBD.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Cell Biology
Xudong Huang
Summary: Alzheimer's disease (AD) is a pandemic that causes significant social and economic burden, and currently, there is no effective treatment available. Experimental studies have shown that imbalances in cerebral iron and copper levels are related to the neuropathological hallmarks of AD. Targeting iron-dependent cell death, known as ferroptosis, may be a promising therapeutic strategy for AD. Additionally, the role of copper-dependent cell death, known as cuproptosis, in AD neurodegeneration requires further investigation. This concise review aims to stimulate further research in oxidative stress-mediated ferroptosis and cuproptosis in AD.
Review
Medicine, Research & Experimental
Da Zhao, Kailin Yang, Hua Guo, Jinsong Zeng, Shanshan Wang, Hao Xu, Anqi Ge, Liuting Zeng, Shaowu Chen, Jinwen Ge
Summary: Neurodegenerative diseases, such as Alzheimer's disease (AD), pose a serious medical challenge and burden worldwide. The pathogenesis of AD is complex and involves mechanisms such as amyloid plaque formation, tau protein phosphorylation, neuroinflammation, and ferroptosis. Animal studies have shown that iron chelating agents, chloroiodohydroxyquine derivatives, antioxidants, and certain plant products can be effective in AD treatment. This review aims to provide reference information for the development of ferroptosis inhibitors for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Junyu Fan, Ting Jiang, Dongyi He
Summary: This review summarizes recent advancements in the interaction between ferroptosis and the immune system, with a focus on autoimmune diseases. It provides a comprehensive understanding of the critical regulators of ferroptosis and highlights the molecular crosstalk between ferroptosis and different immune cells. Future research is expected to uncover the mechanisms governing ferroptosis and explore its therapeutic potential in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jie Chu, Jingwen Li, Lin Sun, Jianshe Wei
Summary: This article mainly discusses the role of ferroptosis in Parkinson's disease and Alzheimer's disease, and introduces how four cellular defense systems are involved in these two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Sara Chavoshinezhad, Elmira Beirami, Esmael Izadpanah, Marco Feligioni, Kambiz Hassanzadeh
Summary: Alzheimer's disease is a neurodegenerative condition characterized by cognitive decline, neurofibrillary tangles, and amyloid plaques. The involvement of non-apoptotic cell death, particularly necroptosis and ferroptosis, in the neurodegenerative mechanisms of AD has gained significant attention. This review discusses the features and mechanisms of necroptosis and ferroptosis, as well as the latest therapies targeting these processes in AD animal/cell models and human research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Leszek Szablewski
Summary: Alzheimer's disease is the most common cause of dementia in elderly people, with aging being a main risk factor. Impairment of brain energy and glucose hypometabolism are hallmarks of the disease. There are several hypotheses on the role of glucose hypometabolism in AD, but further investigations are needed on this subject.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Anesthesiology
Lachlan F. Miles, Yugeesh R. Lankadeva, Robert D. Sanders, Scott Ayton
Review
Microbiology
Sixin Liu, Catherine A. Butler, Scott Ayton, Eric C. Reynolds, Stuart G. Dashper
Summary: The cause and pathophysiological mechanisms of Alzheimer's disease (AD) are still unknown in medical science. Oral bacteria, especially Porphyromonas gingivalis, are associated with AD pathophysiology in some individuals. P. gingivalis produces proteins that cause tissue damage and inflammation. This bacterium's outer membrane vesicles (OMVs) can cross the blood brain barrier and contribute to neuroinflammation, plaque/tangle formation, and neuronal death.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Scott Ayton, Shorena Janelidze, Pawel Kalinowski, Sebastian Palmqvist, Abdel Ali Belaidi, Erik Stomrud, Anne Roberts, Blaine Roberts, Oskar Hansson, Ashley Ian Bush
Summary: This study investigates the association between iron, inflammation, apolipoprotein, and Alzheimer's disease. It suggests that iron is closely associated with apolipoprotein E and tau pathology, and plays different roles in different stages of the disease, correlating with cognitive deterioration.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Sara Nikseresht, James B. W. Hilton, Jeffrey R. Liddell, Kai Kysenius, Ashley I. Bush, Scott Ayton, HuiJing Koay, Paul S. Donnelly, Peter J. Crouch
Summary: The permeable copper(II) compound is being investigated as a potential treatment for neurodegenerative diseases. The compound accumulates in affected areas of the central nervous system in patients, and studies have shown positive outcomes with transdermal application. This study compared the tissue copper concentrations in mice after oral and transdermal administration, revealing higher concentrations with transdermal application of soluble CuII(atsm). The results suggest that transdermal application could be a viable alternative to oral administration.
Review
Biochemistry & Molecular Biology
Darius J. R. Lane, Francesca Alves, Scott J. J. Ayton, Ashley I. I. Bush
Summary: The lack of disease-modifying treatments for Alzheimer's disease (AD) highlights the need for new biological models of disease progression and neurodegeneration. Oxidation of macromolecules within the brain, as well as dysregulation of redox-active metals like iron, are believed to contribute to AD pathophysiology. Creating a unified model of disease progression based on iron and redox dysregulation could lead to new therapeutic targets with disease-modifying potential.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Correction
Cell Biology
Odette Leiter, Zhan Zhuo, Ruslan Rust, Joanna M. Wasielewska, Lisa Gronnert, Susann Kowal, Rupert W. Overall, Vijay S. Adusumilli, Daniel G. Blackmore, Adam Southon, Katherine Ganio, Christopher A. Mcdevitt, Nicole Rund, David Brici, Imesh Aththanayake Mudiyan, Alexander M. Sykes, Annette E. Runker, Sara Zocher, Scott Ayton, Ashley I. Bush, Perry F. Bartlett, Sheng-Tao Hou, Gerd Kempermann, Tara L. Walker
Article
Biochemistry & Molecular Biology
Amit Lotan, Sandra Luza, Carlos M. Opazo, Scott Ayton, Darius J. R. Lane, Serafino Mancuso, Avril Pereira, Suresh Sundram, Cynthia Shannon Weickert, Chad Bousman, Christos Pantelis, Ian P. Everall, Ashley I. Bush
Summary: Current treatments for schizophrenia do not target disruptions in late maturational reshaping of the prefrontal cortex. Analysis of cortical iron biology in schizophrenia reveals elevated tissue iron and decreased ferritin, suggesting a potential link between perturbed cortical iron biology and the disorder, and offering a new therapeutic target.
MOLECULAR PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Yen Ying Lim, Nawaf Yassi, Lisa Bransby, Scott Ayton, Rachel F. Buckley, Dhamidhu Eratne, Dennis Velakoulis, Qiao-Xin Li, Christopher Fowler, Colin L. Masters, Paul Maruff
Summary: This study aimed to determine the relationship between the APOE ε4 allele and biomarkers of Alzheimer's disease in cerebrospinal fluid and neuroimaging, as well as cognition. The results showed that APOE ε4 carriers had lower levels of Aβ42 and higher levels of tau and neurofilament light in the CSF, as well as poorer cognitive performance.
NEUROBIOLOGY OF AGING
(2023)
Article
Clinical Neurology
Francesca Alves, Pawel Kalinowski, Scott Ayton
Summary: This study evaluates the brain volume changes caused by different subclasses of anti-beta-amyloid drugs in Alzheimer patients. The findings suggest that these drugs may accelerate brain atrophy and have varying effects on different brain regions.
Editorial Material
Neurosciences
Boyd Kenkhuis, Ashley I. Bush, Scott Ayton
Summary: Iron overload has been recognized as a factor in neurodegenerative diseases, with microglia being particularly susceptible to iron overload-induced ferroptosis, as revealed by recent research. The evidence of microglial ferroptosis in clinical specimens suggests that inhibitors of ferroptosis may have therapeutic potential for these diseases.
TRENDS IN NEUROSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Salvatore P. Mangiafico, Qing-Zhang Tuo, Xiao-Lan Li, Yu Liu, Christian Haralambous, Xu-Long Ding, Scott Ayton, Qing Wang, D. Ross Laybutt, Jeng Yie Chan, Xiang Zhang, Cameron Kos, Helen E. Thomas, Thomas Loudovaris, Chieh-Hsin Yang, Christos N. Joannides, Benjamin J. Lamont, Lunzhi Dai, Hai-Huai He, Biao Dong, Sofianos Andrikopoulos, Ashley I. Bush, Peng Lei
Summary: Tau protein plays a crucial role in regulating insulin secretion and glucose homeostasis in response to glucose stimulation, and a potential relationship between T2DM and AD has been established.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Jae Pyun, Huijing Koay, Pranav Runwal, Celeste Mawal, Ashley I. Bush, Yijun Pan, Paul S. Donnelly, Jennifer L. Short, Joseph A. Nicolazzo
Summary: Cu(ATSM) enhances the expression and function of P-gp at the blood-brain barrier, which has important implications for CNS drug delivery and clearance of A beta in AD.
Article
Telecommunications
Denzil Furtado, Andre F. Gygax, Chien Aun Chan, Ashley I. Bush
Summary: Situated at the intersection of technology and medicine, the Internet of Things (IoT) holds the promise of addressing some of healthcare's most pressing challenges. However, the successful implementation of IoT healthcare initiatives has been slow. To promote collaboration, a problem-oriented approach to developing healthcare technologies is proposed. Fog computing is suggested as the most promising technological paradigm for building a robust and scalable healthcare IoT ecosystem.
DIGITAL COMMUNICATIONS AND NETWORKS
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
