Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products

Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

(2015) William M. Hewitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

(2014) Daniel S. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection-Based Discovery of Druglike Macrocyclic Peptides

(2014) Toby Passioura et al.   Annual Review of Biochemistry

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

(2014) Bradley Croy Doak et al.   CHEMISTRY & BIOLOGY

Factor XII: a drug target for safe interference with thrombosis and inflammation

(2014) Ellinor Kenne et al.   DRUG DISCOVERY TODAY

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

(2014) Jason Gavenonis et al.   Nature Chemical Biology

Tools and rules for macrocycles

(2014) Christian Heinis   Nature Chemical Biology

How proteins bind macrocycles

(2014) Elizabeth A Villar et al.   Nature Chemical Biology

Flexizyme-Mediated Genetic Reprogramming As a Tool for Noncanonical Peptide Synthesis and Drug Discovery

(2013) Toby Passioura et al.   CHEMISTRY-A EUROPEAN JOURNAL

Form and Function in Cyclic Peptide Natural Products: A Pharmacokinetic Perspective

(2013) Andrew T. Bockus et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Bicycles that Inhibit the Grb2 SH2 Domain

(2012) Justin S. Quartararo et al.   CHEMBIOCHEM

The future of antibodies as cancer drugs

(2012) Janice M. Reichert et al.   DRUG DISCOVERY TODAY

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Testing Physical Models of Passive Membrane Permeation

(2012) Siegfried S. F. Leung et al.   Journal of Chemical Information and Modeling

Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation

(2012) Cristiano R. W. Guimarães et al.   Journal of Chemical Information and Modeling

Predicting and Improving the Membrane Permeability of Peptidic Small Molecules

(2012) Salma B. Rafi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spatial structure of cyclosporin A and insight into its flexibility

(2012) S.V. Efimov et al.   JOURNAL OF MOLECULAR STRUCTURE

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

(2012) Arthur C. Rand et al.   MedChemComm

hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability

(2011) Alessandro Ettorre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides

(2011) Oded Ovadia et al.   MOLECULAR PHARMACEUTICS

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Unambiguous Assignment of Vibrational Spectra of Cyclosporins A and H†

(2010) Zheng-wang Qu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Investigation of the Relative Cellular Permeability of DNA-Binding Pyrrole−Imidazole Polyamides

(2009) Bo Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY