AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications

Functional insight into development of positive allosteric modulators of AMPA receptors

(2014) Autumn M. Weeks et al.   NEUROPHARMACOLOGY

1-(1,3-Benzodioxol-5-yl-carbo-nyl) Piperidine, a Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor, Ameliorates Exercise-Induced Fatigue in Mice

(2013) Wutu Fan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Allosteric Modulators for the Treatment of Schizophrenia: Targeting Glutamatergic Networks

(2013) Frank S. Menniti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice

(2013) Julie Vignisse et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

AMPA receptor positive allosteric modulators: a patent review

(2013) Bernard Pirotte et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery and Characterization of a Novel Dihydroisoxazole Class of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators

(2013) Nandini C. Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold

(2013) Ann-Beth Nørholm et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Translational Approach to Evaluate the Efficacy and Safety of the Novel AMPA Receptor Positive Allosteric Modulator Org 26576 in Adult Attention-Deficit/Hyperactivity Disorder

(2012) Lenard A. Adler et al.   BIOLOGICAL PSYCHIATRY

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

(2012) Haijun Chen et al.   ChemMedChem

Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease

(2012) Paula T. Trzepacz et al.   INTERNATIONAL PSYCHOGERIATRICS

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

(2012) Kari R Nations et al.   JOURNAL OF PSYCHOPHARMACOLOGY

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

(2012) J.L. Silverman et al.   NEUROPHARMACOLOGY

Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: Part II

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation

(2011) Mark L Mayer   CURRENT OPINION IN NEUROBIOLOGY

Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation

(2011) D. E. Timm et al.   MOLECULAR PHARMACOLOGY

Emerging Models of Glutamate Receptor Ion Channel Structure and Function

(2011) Mark L. Mayer   STRUCTURE

New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

(2011) Gaëlle Dintilhac et al.   MedChemComm

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

(2011) Umberto M. Battisti et al.   ACS Medicinal Chemistry Letters

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges for and current status of research into positive modulators of AMPA receptors

(2010) Simon E Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA-Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

(2010) Katy Bernard et al.   CNS Neuroscience & Therapeutics

Recent Advances in the Discovery of Selective AMPA Receptor Positive Allosteric Modulators

(2010) Simon E. Ward et al.   CURRENT MEDICINAL CHEMISTRY

Discovery ofN-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator

(2010) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor

(2010) Simon J. A. Grove et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators

(2010) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors

(2010) N. F. Shanks et al.   JOURNAL OF NEUROSCIENCE

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

(2010) Jacob Pøhlsgaard et al.   NEUROPHARMACOLOGY

Selective Antagonism of Opioid-Induced Ventilatory Depression by an Ampakine Molecule in Humans Without Loss of Opioid Analgesia

(2009) B G Oertel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

NEUROSCIENCE: More AMPAR Garnish

(2009) C. Tigaret et al.   SCIENCE

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

(2009) J. Schwenk et al.   SCIENCE

A novel class of allosteric modulators of AMPA/Kainate receptors

(2008) Giuseppe Cannazza et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

(2008) Carlos A. Zarate et al.   EXPERIMENTAL NEUROLOGY

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Targeting AMPA and kainate receptors in neurological disease: therapies on the horizon?

(2008) Geoffrey T Swanson   NEUROPSYCHOPHARMACOLOGY

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

(2008) J.C. Lauterborn et al.   NEUROSCIENCE

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat

(2008) M. L. Woolley et al.   PSYCHOPHARMACOLOGY