Inosine 5′-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives

Novel Approaches Are Needed to Develop Tomorrow’s Antibacterial Therapies

(2015) Brad Spellberg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Appropriate antimicrobial therapy in the era of multidrug-resistant human pathogens

(2015) J.M. Pogue et al.   CLINICAL MICROBIOLOGY AND INFECTION

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity

(2015) Magdalena Makowska-Grzyska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

(2015) Thomas Alexandre et al.   PLoS One

Anthrax: A disease of biowarfare and public health importance

(2015) Ajay Kumar Goel   World Journal of Clinical Cases

From crystal to compound: structure-based antimalarial drug discovery

(2014) Nyssa Drinkwater et al.   BIOCHEMICAL JOURNAL

Counteracting antibiotic resistance: breaking barriers among antibacterial strategies

(2014) Fernando Baquero et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Synthesis, in Vitro Evaluation and Cocrystal Structure of 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) Inhibitors

(2014) Zhuming Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

(2014) Kavitha Mandapati et al.   ACS Medicinal Chemistry Letters

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

(2013) Suresh Kumar Gorla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CBS domains: Ligand binding sites and conformational variability

(2013) June Ereño-Orbea et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines

(2013) Zhao-Jin Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

(2013) Torsten Dunkern et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2013) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade

(2013) Riccardo Petrelli et al.   Recent Patents on Anti-Cancer Drug Discovery

MgATP Regulates Allostery and Fiber Formation in IMPDHs

(2013) Gilles Labesse et al.   STRUCTURE

Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes

(2012) Magdalena Makowska-Grzyska et al.   BIOCHEMISTRY

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

(2012) Sivapriya Kirubakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

(2012) Corey R. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enteric Protozoa in the Developed World: a Public Health Perspective

(2012) S. M. Fletcher et al.   CLINICAL MICROBIOLOGY REVIEWS

Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5′-monophosphate dehydrogenase II (IMPDH II) inhibitors

(2012) Torsten Dunkern et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2012) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

(2012) Veeraraghavan Usha et al.   PLoS One

The CBS Domain: A Protein Module with an Emerging Prominent Role in Regulation

(2011) Alexander A. Baykov et al.   ACS Chemical Biology

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain

(2011) Krzysztof Felczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Three-Dimensional Pharmacophore Model for IMPDH Inhibitors

(2011) Na Yang et al.   Chemical Biology & Drug Design

The Antibiotic Potential of Prokaryotic IMP Dehydrogenase Inhibitors

(2011) L. Hedstrom et al.   CURRENT MEDICINAL CHEMISTRY

Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells

(2010) M. Khan et al.   ANTIVIRAL RESEARCH

Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

(2010) Issei DAIRAKU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases

(2010) Deviprasad R. Gollapalli et al.   CHEMISTRY & BIOLOGY

Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human andMycobacterium tuberculosis

(2010) Liqiang Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

(2010) Iain S. MacPherson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis

(2010) V. Usha et al.   MICROBIOLOGY-SGM

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

(2010) Lisa Sharling et al.   PLoS Neglected Tropical Diseases

A heterocyclic molecule with significant activity against dengue virus

(2009) Vasu Nair et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics

(2009) Sonja B Braun-Sand et al.   Future Medicinal Chemistry

Triazole Inhibitors ofCryptosporidium parvumInosine 5′-Monophosphate Dehydrogenase

(2009) Sushil K. Maurya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

(2008) Nwakaso N. Umejiego et al.   CHEMISTRY & BIOLOGY