Journal
FOOD CHEMISTRY
Volume 245, Issue -, Pages 29-38Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.10.083
Keywords
Nanoflow liquid chromatography; Mass spectrometry high resolution; Veterinary drugs; Matrix effect
Funding
- Spanish Ministerio de Economia y Competitividad (MINECO) [CTQ2015-71321-P, FJCI-2014-19573]
- FEDER funds
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In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 mu g kg(-1) before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10).
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