Journal
FOOD CHEMISTRY
Volume 241, Issue -, Pages 290-300Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.08.111
Keywords
Rosa dumalis Bechst; Rosa dumetorum Thuill; Rosa sempervirens L.; LC-MS/MS; Anti-inflammatory activity; Antioxidant activity; Anti-acetylcholinesterase activity; Cytotoxic activity
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172058]
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The aim of the present study was investigation of the phenolic profile, ascorbic acid content, antioxidant, anti-acetylcholinesterase, anti-inflammatory and cytotoxic activity of rose hips and the preserves (puree and jam) of three insufficiently examined Rosa species: Rosa dumalis Bechst., R. dumetorum Thuill. and R. sempervirens L. The liquid chromatography-tandem mass spectrometry analysis resulted in quantification of 14 of the 45 phenolic compounds examined, with ellagic acid as the most dominant. Notable antioxidant activity of all three species was confirmed through several assays. Moderate inhibition of acetylcholinesterase by extracts of all investigated Rosa species was observed. Several extracts of examined Rosa species demonstrated inhibition potency towards production of some monitored eicosanoids in cyclooxygenase-1 and 12-lipoxygenase pathways. Two R. sempervirens extracts exerted cytotoxic activity against HeLa and HT-29 cell lines, but were inactive towards MRC-5 and MCF7. The results support the potential of these rose hips as food with health-promoting properties.
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