Codon harmonization - going beyond the speed limit for protein expression

Effect of DNA sequence of Fab fragment on yield characteristics and cell growth of E. coli

(2017) Antti Kulmala et al.   Scientific Reports

Widespread position-specific conservation of synonymous rare codons within coding sequences

(2017) Julie L. Chaney et al.   PLoS Computational Biology

Synthetic gene design-The rationale for codon optimization and implications for molecular pharming in plants

(2016) Gina R. Webster et al.   BIOTECHNOLOGY AND BIOENGINEERING

Roles for Synonymous Codon Usage in Protein Biogenesis

(2015) Julie L. Chaney et al.   Annual Review of Biophysics

Multi-omic profiling ­of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

(2015) Daniel Ley et al.   BIOTECHNOLOGY AND BIOENGINEERING

ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization

(2015) Edward Daniel et al.   BMC BIOINFORMATICS

Rationally designed, heterologousS. cerevisiaetranscripts expose novel expression determinants

(2015) Tuval Ben-Yehezkel et al.   RNA Biology

Codon Optimisation Is Key for Pernisine Expression in Escherichia coli

(2015) Marko Šnajder et al.   PLoS One

Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

(2014) Ju Xin Chin et al.   BIOINFORMATICS

A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae

(2014) Amanda M Lanza et al.   BMC Systems Biology

Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development

(2014) A. Nogales et al.   JOURNAL OF VIROLOGY

Multiple roles of the coding sequence 5′ end in gene expression regulation

(2014) Tamir Tuller et al.   NUCLEIC ACIDS RESEARCH

Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus

(2014) Yan-Yan Ni et al.   VIROLOGY

Speed Controls in Translating Secretory Proteins in Eukaryotes - an Evolutionary Perspective

(2014) Shelly Mahlab et al.   PLoS Computational Biology

Efficient translation initiation dictates codon usage at gene start

(2013) K. Bentele et al.   Molecular Systems Biology

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Non-optimal codon usage is a mechanism to achieve circadian clock conditionality

(2013) Yao Xu et al.   NATURE

Causes and Effects of N-Terminal Codon Bias in Bacterial Genes

(2013) D. B. Goodman et al.   SCIENCE

Identification and characterization of antigens as vaccine candidates againstKlebsiella pneumoniae

(2013) Urban Lundberg et al.   Human Vaccines & Immunotherapeutics

tRNA concentration fine tunes protein solubility

(2012) Ivan Fedyunin et al.   FEBS LETTERS

Engineering genes for predictable protein expression

(2012) Claes Gustafsson et al.   PROTEIN EXPRESSION AND PURIFICATION

Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity

(2012) Ijeoma Ejigiri et al.   PLoS Pathogens

Codon usage: Nature's roadmap to expression and folding of proteins

(2011) Evelina Angov   Biotechnology Journal

Comparison of two codon optimization strategies to enhance recombinant protein production in Escherichia coli

(2011) Hugo G Menzella   Microbial Cell Factories

How the Sequence of a Gene Can Tune Its Translation

(2010) Kurt Fredrick et al.   CELL

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence-Dependent Degradation

(2010) F. Zhang et al.   SCIENCE

Design Parameters to Control Synthetic Gene Expression in Escherichia coli

(2009) Mark Welch et al.   PLoS One

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Distance Learning for Similarity Estimation

(2008) Jie Yu et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

Heterologous Protein Expression Is Enhanced by Harmonizing the Codon Usage Frequencies of the Target Gene with those of the Expression Host

(2008) Evelina Angov et al.   PLoS One

A pause for thought along the co-translational folding pathway

(2008) Anton A. Komar   TRENDS IN BIOCHEMICAL SCIENCES