Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

(2017) Avi Ashkenazi et al.   NATURE REVIEWS DRUG DISCOVERY

Mcl-1 stabilization confers resistance to taxol in human gastric cancer

(2017) Wu Shuang et al.   Oncotarget

Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt

(2016) Dejuan Kong et al.   EXPERIMENTAL EYE RESEARCH

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors

(2016) Taekyu Lee et al.   FEBS LETTERS

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

(2016) Gizem Akçay et al.   Nature Chemical Biology

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

(2016) Ingela B Vikström et al.   Cell Death & Disease

Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation

(2016) Shardule P. Shah et al.   Oncotarget

DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

(2016) Wataru Nakajima et al.   Oncotarget

EGFR signaling defines Mcl-1 survival dependency in neuroblastoma

(2015) Srilatha Nalluri et al.   CANCER BIOLOGY & THERAPY

Dexamethasone treatment promotes Bcl-2 dependence in multiple myeloma resulting in sensitivity to venetoclax

(2015) S M Matulis et al.   LEUKEMIA

Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia

(2015) B T Gaudette et al.   ONCOGENE

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

(2014) C L Buchheit et al.   CELL DEATH AND DIFFERENTIATION

Bcl-xLProtein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation

(2014) Brian T. Gaudette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function

(2014) Matthew Brentnall et al.   JOURNAL OF CELL SCIENCE

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues

(2014) Nathiya Muthalagu et al.   Cell Reports

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1

(2013) M Moustafa-Kamal et al.   CELL DEATH AND DIFFERENTIATION

Seeking a MCL-1 inhibitor

(2013) G Brumatti et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK

(2013) A Geissler et al.   CELL DEATH AND DIFFERENTIATION

Evaluation and critical assessment of putative MCL-1 inhibitors

(2013) S Varadarajan et al.   CELL DEATH AND DIFFERENTIATION

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo

(2012) C Clybouw et al.   CELL DEATH AND DIFFERENTIATION

Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute – Waldenström Macroglobulinemia 1

(2012) Kasyapa S. Chitta et al.   LEUKEMIA & LYMPHOMA

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

(2012) Shouqing Luo et al.   MOLECULAR CELL

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

(2011) Patricia Gomez-Bougie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells

(2011) A. A. Morales et al.   BLOOD

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation

(2009) Ozgur Kutuk et al.   CARCINOGENESIS

Antiapoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-Induced Hepatocyte Apoptosis

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

(2009) Joslyn K. Brunelle et al.   JOURNAL OF CELL BIOLOGY

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

(2009) Elinor Dehan et al.   MOLECULAR CELL

BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma

(2008) A. A. Morales et al.   BLOOD

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

(2008) Anette Hübner et al.   MOLECULAR CELL