Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors
Authors
Keywords
-
Journal
FEBS LETTERS
Volume 591, Issue 1, Pages 240-251
Publisher
Wiley
Online
2016-11-23
DOI
10.1002/1873-3468.12497
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
- (2016) Nicholas F. Pelz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines
- (2016) Brian Koss et al. Oncotarget
- Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
- (2015) C M Goodwin et al. CELL DEATH AND DIFFERENTIATION
- The BCL-2 protein family, BH3-mimetics and cancer therapy
- (2015) A R D Delbridge et al. CELL DEATH AND DIFFERENTIATION
- Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design
- (2015) Jason P. Burke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
- (2015) Milan Bruncko et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
- (2015) J D Leverson et al. Cell Death & Disease
- Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
- (2014) Glenna Wink Foight et al. ACS Chemical Biology
- 3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation
- (2014) Fardokht A. Abulwerdi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rational Use of Plasma Protein and Tissue Binding Data in Drug Design
- (2014) Xingrong Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker
- (2013) David J. Richard et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins
- (2013) Yuta Tanaka et al. JOURNAL OF MEDICINAL CHEMISTRY
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia
- (2013) R. Pan et al. Cancer Discovery
- Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
- (2012) Anders Friberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells
- (2011) A. A. Morales et al. BLOOD
- Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
- (2011) Ingrid E. Wertz et al. NATURE
- Mcl-1; the molecular regulation of protein function
- (2010) Luke W. Thomas et al. FEBS LETTERS
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
- (2010) Michelle L Stewart et al. Nature Chemical Biology
- A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
- (2010) W J Placzek et al. Cell Death & Disease
- Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell
- (2008) San-Hua Wei et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
- (2008) M Vogler et al. CELL DEATH AND DIFFERENTIATION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now