Article
Biochemistry & Molecular Biology
Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lu, Shi-You Chen, Wei-Bing Xie
Summary: The study identified Nupr1 as a novel regulator promoting renal fibrosis, essential for fibroblast activation and/or epithelial-mesenchymal transition during renal fibrogenesis. Nupr1 mediated TGF-beta-induced myofibroblast activation and collagen synthesis by initiating Smad3 signaling pathway, and the Nupr1 inhibitor alleviated UUO-induced renal fibrosis.
Article
Biochemistry & Molecular Biology
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
Summary: The crosstalk between macrophages and tubular epithelial cells is important in the progression of renal fibrosis. In this study, the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of tubular epithelial cells, and the development of renal fibrosis was revealed. circACTR2 promoted the activation of NLRP3 inflammasome, inflammation in macrophages, and stimulated EMT and fibrosis of tubular epithelial cells by sponging miR-561. Knocking down circACTR2 and overexpressing miR-561 may benefit the treatment of renal fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Iori Motoo, Sohachi Nanjo, Takayuki Ando, Satoshi Yamashita, Toshikazu Ushijima, Ichiro Yasuda
Summary: The study reveals that in diffuse-type gastric cancers, ULK2 is methylated and knockdown of ULK2 can induce autophagy, cell migration, and EMT. mRNA microarray analysis showed that knockdown of ULK2 altered the expressions of oncogenic genes associated with cell migration and EMT.
Review
Biochemistry & Molecular Biology
Jian Qin, Jian Xu
Summary: Arginine methylation plays a critical role in regulating EMT, affecting signaling, transcription, and splicing regulation.
Article
Biochemical Research Methods
Dan Huang, Xiansong Wang, Yingzhi Liu, Ziheng Huang, Xiaoxu Hu, Wei Hu, Qing Li, Hung Chan, Yidan Zou, Idy H. T. Ho, Yan Wang, Alfred S. L. Cheng, Wei Kang, Ka F. To, Maggie H. T. Wang, Sunny H. Wong, Jun Yu, Tony Gin, Qingpeng Zhang, Zheng Li, Jianxiong Shen, Lin Zhang, Matthew T. Chan, Xiaodong Liu, William K. K. Wu
Summary: Tumor suppressor genes exhibit unique promoter features that optimize cancer resistance by achieving high expression in normal tissues and resisting downregulation during tumorigenesis. The CpG dinucleotide frequencies in TSG promoters are higher and positively correlated with gene expression, suggesting an evolutionary pressure on young TSGs. Higher CpG frequencies and chromatin accessibility are associated with the ability of TSGs to resist downregulation during tumorigenesis.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Kim Lommen, Nathalie Vaes, Maureen J. Aarts, Joep G. van Roermund, Leo J. Schouten, Egbert Oosterwijk, Veerle Melotte, Vivianne C. Tjan-Heijnen, Manon van Engeland, Kim M. Smits
Summary: This systematic review examined the diagnostic value of DNA methylation biomarkers for RCC, indicating a lack of independently validated biomarkers and inadequate reporting in the majority of studies.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zisheng Huang, Han Nie, Geng Liu, Peilin Li, Yong-Hua Peng, Jie Xiao, Weili Gu, Tao-Sheng Li
Summary: This study investigated the effectiveness and mechanism of angiotensin receptor blockers (ARBs) in alleviating renal fibrosis. It found that losartan, even at a low dose, can attenuate renal fibrosis by inhibiting the epithelial to mesenchymal transition (EMT) of renal epithelial cells induced by biomechanical stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Endocrinology & Metabolism
Pavlos Fanis, Maria Morrou, Marios Tomazou, Kyriaki Michailidou, George M. M. Spyrou, Meropi Toumba, Nicos Skordis, Vassos Neocleous, Leonidas A. A. Phylactou
Summary: Makorin RING finger protein 3 (MKRN3) is an important factor associated with Prader-Willi syndrome. It is expressed in the hypothalamus and mutations in the gene have been found in patients with central precocious puberty. The methylation status of the Mkrn3 promoter was investigated in female mice and differential methylation patterns were observed between pre-pubertal and pubertal/post-pubertal stages.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Jian Zhou, Rui Li, Qinhui Liu, Jinhang Zhang, Hui Huang, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Tong Wu, Qin Tang, Ya Huang, Zijing Zhang, Yanping Li, Jinhan He
Summary: The enzyme 5-lipoxygenase (5-LO) promotes renal fibrosis by inducing epithelial-mesenchymal transition (EMT) in kidney cells. Deletion or inhibition of 5-LO can reduce renal fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Hong-Cheng Lv, Yan-Yan Lv, Gang Wang, Xie-Hua Zhang, Sheng-Nan Li, Xiao-Fen Yue, Wei Lu
Summary: The current study aimed to investigate the role of miR-424-5p promoter methylation in epithelial mesenchymal transition (EMT) of hepatocellular carcinoma (HCC) cells. The results showed that miR-424-5p was poorly expressed and highly methylated in HCC tissues and cells. Upregulation of miR-424-5p reduced cell viability and increased apoptosis, accompanied by changes in N-cadherin and E-cadherin levels. Further experiments revealed that miR-424-5p interacted with KIF2A and downregulated its expression. In vivo studies showed that miR-424-5p overexpression inhibited KIF2A downregulation and attenuated tumor growth.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Yan Li, Bei Song, Chengchao Ruan, WenJie Xue, Jianrong Zhao
Summary: The study demonstrated that AdipoRon inhibits EMT in the kidney by activating the AMPK/ULK1 pathway, leading to the improvement of renal fibrosis induced by hypertension. This suggests that AdipoRon could be a potential therapeutic option for preventing renal fibrosis in hypertensive patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Qi Wang, Fuqiang Wang, Xiangze Li, Zhi Ma, Dapeng Jiang
Summary: This study investigated the effect of quercetin treatment on renal fibrosis and its mechanism. The results showed that quercetin can alleviate fibrosis, inflammation, oxidative stress, and cell apoptosis. Quercetin alleviates fibrosis by inhibiting the activation of AREG/EGFR signaling.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yanwen Mao, Xiaohuan Zhang, Wei Peng, Huiming Liu, Xingchen Zhou, Luqun Liang, Jiayi Xiang, Huifang Zhang, Dan Wang, Lingling Liu, Yuxia Zhou, Fan Zhang, Ying Xiao, Mingjun Shi, Yuanyuan Wang, Bing Guo
Summary: EI24 plays a tumor suppressor role in kidney diseases by inhibiting renal interstitial fibrosis through inhibiting epithelial-mesenchymal transition and excessive extracellular matrix deposition, as well as reducing inflammation by restraining NF-kappa B and JNK pathways.
Article
Biochemistry & Molecular Biology
Tiantian Liu, Pengli Xu, Shaorui Ke, Haoran Dong, Mengmeng Zhan, Qin Hu, Jiansheng Li
Summary: SETDB1 regulates Snai1 expression epigenetically, driving EMT gene reprogramming and ferroptosis in response to TGF-beta. However, the links between epigenetic reprogramming and transcriptional processes in TGF-beta-dependent EMT regulation remain unexplored.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Sheng Tan, Jili Chen
Summary: The study investigated the impact of HMGA2 on epithelial-mesenchymal transition (EMT) in thymic cancer cells, suggesting that si-HMGA2 may regulate EMT via the Wnt/β-catenin pathway.
Article
Multidisciplinary Sciences
Hui Min Lee, Alice Pei Eal Sia, Lili Li, Hans Prakash Sathasivam, Melissa Sue Ann Chan, Pathmanathan Rajadurai, Chi Man Tsang, Sai Wah Tsao, Paul G. Murray, Qian Tao, Ian C. Paterson, Lee Fah Yap
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao, Tingxiu Xiang
CLINICAL EPIGENETICS
(2020)
Article
Oncology
Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang, Tingxiu Xiang
Summary: This study evaluated the potential tumor suppressor gene ZBTB28 as a marker for cervical cancer assessment. The research found that ZBTB28 can induce autophagy-related apoptosis in cervical cancer cells, inhibiting tumor growth. Furthermore, ZBTB28 promoter methylation analysis may offer a new objective strategy for cervical cancer screening.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Kenneth C. W. Wong, Edwin P. Hui, Kwok-Wai Lo, Wai Kei Jacky Lam, David Johnson, Lili Li, Qian Tao, Kwan Chee Allen Chan, Ka-Fai To, Ann D. King, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: Over the past three decades, significant progress has been made in understanding the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer. Technological advances have led to the introduction of proton therapy and other contemporary radiotherapy approaches, with continued efforts to determine the optimal sequencing of chemotherapy with radiotherapy through decades of clinical trials.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Tang, Weiyan Peng, Yixiao Feng, Xin Le, Kang Wang, Qin Xiang, Lili Li, Yan Wang, Can Xu, Junhao Mu, Ke Xu, Ping Ji, Qian Tao, Ailong Huang, Chu-Xia Deng, Yong Lin, Tingxiu Xiang
Summary: This study discusses the importance of inactivation of tumor-suppressor genes in oncogenesis, as well as the role of a novel epigenetic regulatory mechanism in p53 inactivation.
Article
Biochemistry & Molecular Biology
Ke Ying, Chan Wang, Shuiping Liu, Yeye Kuang, Qian Tao, Xiaotong Hu
Summary: This study identified the crucial roles of DIRAS2 in colorectal cancer, suggesting its potential as a tumor-suppressor gene and revealing a distinct mechanism in CRC tumorigenesis. Downregulation of DIRAS2 expression is associated with poor prognosis in CRC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Correction
Medicine, Research & Experimental
Lili Li, Juan Xu, Guohua Qiu, Jianming Ying, Zhenfang Du, Tingxiu Xiang, Kai Yau Wong, Gopesh Srivastava, Xiao-Feng Zhu, Tony S. Mok, Anthony T. C. Chan, Francis K. L. Chan, Richard F. Ambinder, Qian Tao
Article
Multidisciplinary Sciences
Ying Ying, Maolin Wang, Yongheng Chen, Meiqi Li, Canjie Ma, Junbao Zhang, Xiaoyan Huang, Min Jia, Junhui Zeng, Yejun Wang, Lili Li, Xiaomei Wang, Qian Tao, Xing-Sheng Shu
Summary: This study unveiled the role of zinc finger protein 280C (ZNF280C) in colorectal cancer (CRC) and its significance in colitis-associated carcinogenesis and intestinal tumorigenesis. Silencing ZNF280C in human CRC cells inhibited cell proliferation and migration, and predicted worse prognosis in patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yeye Kuang, Zhanglian He, Lili Li, Chan Wang, Xiaoqing Cheng, Qinglan Shi, Guoxiang Fu, Jianming Ying, Qian Tao, Xiaotong Hu
Summary: This study reveals that HAND1 is frequently downregulated in gastric cancer due to promoter methylation, and its low expression is correlated with tumor progression and poor prognosis. High expression of HAND1 is associated with higher 5-year overall survival rates in gastric cancer patients. HAND1 inhibits gastric cancer cell growth and migration through induction of endoplasmic reticulum (ER) stress and apoptosis. The methylation status of HAND1 promoter could be a potential biomarker for gastric cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Virology
Joanna W. Y. Ho, Lili Li, Kai Yau Wong, Gopesh Srivastava, Qian Tao
Summary: The expression pattern of EBV genes in PTCL was mainly latency II, but occasionally fully lytic infection could also be detected. These findings have implications for the future development of EBV-targeting therapeutics for this cancer.
Article
Biochemistry & Molecular Biology
Lili Li, Xing-sheng Shu, Hua Geng, Jianming Ying, Lei Guo, Jie Luo, Tingxiu Xiang, Longtao Wu, Brigette B. Y. Ma, Anthony T. C. Chan, Xiaofeng Zhu, Richard F. Ambinder, Qian Tao
Summary: Peptides/small proteins encoded by noncanonical open reading frames (ORF) of previously claimed non-coding RNAs have important biological functions but are largely uncharacterized. In this study, we identified and validated a small protein SP0495 as a novel tumor suppressor, frequently inactivated by promoter methylation in multiple tumors. SP0495 functions as a phosphoinositide-binding protein, regulating AKT signaling activation and autophagy. It inhibits tumor cell growth and induces apoptosis, cell cycle arrest, senescence, and autophagy through multiple mechanisms, including the modulation of phosphoinositides turnover and autophagic/proteasomal degradation of autophagy regulators. SP0495 has the potential to be a biomarker for cancer diagnosis and prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Lok Seng Chan, Johnson Liu, Molly S. C. Li, Lili Li, Qian Tao, Tony S. K. Mok
Summary: Selenite is found to induce both apoptosis and ferroptosis in lung cancer cells, especially those with EGFR and KRAS mutations. It activates the p38-ATF4-DDIT3 pathway for ferroptosis induction and influences DNA methylation machinery. Combining selenite with osimertinib or adagrasib enhances the therapeutic effect.
CLINICAL EPIGENETICS
(2023)
Meeting Abstract
Oncology
Yingjun Zhang, Connie Hui, Chi Hang Wong, Chi Tung Choy, Teresa Tse, Teresa Tan, Sampson Kwan, Qian Tao, Herbert Loong