Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis

Loss of laminin-α4 results in pre- and postsynaptic modifications at the neuromuscular junction

(2017) Kirat K. Chand et al.   FASEB JOURNAL

Evidence for dying-back axonal degeneration in age-associated skeletal muscle decline

(2017) Tae Chung et al.   MUSCLE & NERVE

Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

(2016) Kirat K. Chand et al.   Scientific Reports

Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice

(2016) Hiroshi Nishimune et al.   Scientific Reports

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model

(2015) D. Arbour et al.   JOURNAL OF NEUROSCIENCE

An Age-Dependent Change in the Set Point of Synaptic Homeostasis

(2014) R. E. Mahoney et al.   JOURNAL OF NEUROSCIENCE

Loss of β2-laminin alters calcium sensitivity and voltage-gated calcium channel maturation of neurotransmission at the neuromuscular junction

(2014) Kirat K. Chand et al.   JOURNAL OF PHYSIOLOGY-LONDON

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Neuromuscular synaptogenesis: coordinating partners with multiple functions

(2014) Houssam Darabid et al.   NATURE REVIEWS NEUROSCIENCE

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response

(2014) Tao Zhang et al.   PLoS Genetics

Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development

(2013) Matthew J. Fogarty et al.   Brain Structure & Function

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

(2013) John D Lee et al.   Journal of Neuroinflammation

Calcium Channel Agonists Protect against Neuromuscular Dysfunction in a Genetic Model of TDP-43 Mutation in ALS

(2013) G. A. B. Armstrong et al.   JOURNAL OF NEUROSCIENCE

Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS

(2013) M. Shahidullah et al.   JOURNAL OF NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Genetic Deficiency of GABA Differentially Regulates Respiratory and Non-Respiratory Motor Neuron Development

(2013) Matthew J. Fogarty et al.   PLoS One

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

(2013) Mariana C. Rocha et al.   PLoS One

TDP-43, an ALS Linked Protein, Regulates Fat Deposition and Glucose Homeostasis

(2013) Nancy R. Stallings et al.   PLoS One

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

(2013) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

(2013) E. S. Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method for the three-dimensional reconstruction of Neurobiotin™-filled neurons and the location of their synaptic inputs

(2013) Matthew J. Fogarty et al.   Frontiers in Neural Circuits

Motor endplate disease affects neuromuscular junction maturation

(2012) Ghislaine Caillol et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis

(2012) Kelly L. Williams et al.   NEUROBIOLOGY OF AGING

Active Zone Protein Bassoon Co-Localizes with Presynaptic Calcium Channel, Modifies Channel Function, and Recovers from Aging Related Loss by Exercise

(2012) Hiroshi Nishimune et al.   PLoS One

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain

(2012) Ramesh K. Narayanan et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

(2011) Vivek Swarup et al.   BRAIN

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

ZPK/DLK, a Mitogen-Activated Protein Kinase Kinase Kinase, Is a Critical Mediator of Programmed Cell Death of Motoneurons

(2011) A. Itoh et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanism of Active Zone Organization at Vertebrate Neuromuscular Junctions

(2011) Hiroshi Nishimune   MOLECULAR NEUROBIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone

(2010) Y. Hida et al.   JOURNAL OF BIOCHEMISTRY

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

(2010) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

(2010) P.-M. Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

(2009) Michael A. Gitcho et al.   ACTA NEUROPATHOLOGICA

Hyperactive Intracellular Calcium Signaling Associated with Localized Mitochondrial Defects in Skeletal Muscle of an Animal Model of Amyotrophic Lateral Sclerosis

(2009) Jingsong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromuscular adaptations to respiratory muscle inactivity

(2009) Carlos B. Mantilla et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Preferential motor unit loss in the SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2008) J. Hegedus et al.   JOURNAL OF PHYSIOLOGY-LONDON

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

(2008) Vivianna M Van Deerlin et al.   LANCET NEUROLOGY

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing

(2008) Keiji Ibata et al.   NEURON

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

(2007) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING