Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4

Exosomes, not protein or lipids, in mesenteric lymph activate inflammation

(2017) Mitsuaki Kojima et al.   Journal of Trauma and Acute Care Surgery

Expression profiles and circulation dynamics of rat mesenteric lymph microRNAs

(2017) Wakako Sakamoto et al.   Molecular Medicine Reports

Exosomes, not protein or lipids, in mesenteric lymph activate inflammation

(2017) Mitsuaki Kojima et al.   Journal of Trauma and Acute Care Surgery

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Involvement of exosomes in lung inflammation associated with experimental acute pancreatitis

(2016) Laia Bonjoch et al.   JOURNAL OF PATHOLOGY

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

(2016) Barbara W Sódar et al.   Scientific Reports

Neuroenteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock

(2015) Koji Morishita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extracellular Vesicles Derived from Gram-Negative Bacteria, such asEscherichia coli, Induce Emphysema Mainly via IL-17A–Mediated Neutrophilic Inflammation

(2015) You-Sun Kim et al.   JOURNAL OF IMMUNOLOGY

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

(2015) SeungHye Han et al.   JOURNAL OF IMMUNOLOGY

A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock

(2015) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

A “CLEAN CASE” OF SYSTEMIC INJURY

(2015) Jeniann Yi et al.   SHOCK

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway

(2015) H-G Moon et al.   Cell Death & Disease

A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock

(2015) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

Diverse macrophage populations mediate acute lung inflammation and resolution

(2014) Neil R. Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor geneECRG4in lung

(2014) Steven Kao et al.   EXPERIMENTAL LUNG RESEARCH

The vagus nerve alters the pulmonary dendritic cell response to injury

(2014) Debra M. Lowry et al.   JOURNAL OF SURGICAL RESEARCH

Critical Role of Toll-Like Receptor 4 in Hypoxia-Inducible Factor 1α Activation During Trauma/Hemorrhagic Shock–Induced Acute Lung Injury After Lymph Infusion in Mice

(2014) Hong Jiang et al.   SHOCK

Dynamic Changes in Rat Mesenteric Lymph Proteins Following Trauma Using Label-Free Mass Spectrometry

(2014) Angelo D’Alessandro et al.   SHOCK

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

(2014) Amy Chow et al.   Scientific Reports

A trigger channel threshold artifact in nanoparticle analysis

(2013) John P. Nolan et al.   CYTOMETRY PART A

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling

(2013) Niko P. Bretz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Group VIB Ca2+-independent phospholipase A2γ is associated with acute lung injury following trauma and hemorrhagic shock

(2013) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry

(2012) Els J van der Vlist et al.   Nature Protocols

Activation of Toll-Like Receptor 4 Is Necessary for Trauma Hemorrhagic Shock-Induced Gut Injury and Polymorphonuclear Neutrophil Priming

(2012) Diego C. Reino et al.   SHOCK

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Circulating microparticles from septic shock patients exert differential tissue expression of enzymes related to inflammation and oxidative stress*

(2011) Maria Letizia Mastronardi et al.   CRITICAL CARE MEDICINE

The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation

(2011) Lee J. McGhan et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Trauma Hemorrhagic Shock-Induced Lung Injury Involves a Gut-Lymph-Induced TLR4 Pathway in Mice

(2011) Diego C. Reino et al.   PLoS One

Claude H. Organ, Jr. Memorial Lecture: Splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase–dependent mechanism

(2010) Ernest E. Moore   AMERICAN JOURNAL OF SURGERY

Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2

(2010) Susu M. Zughaier   JOURNAL OF LEUKOCYTE BIOLOGY

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Potent Anti-Inflammatory Activity of Novel Microtubule-Modulating Brominated Noscapine Analogs

(2010) Susu Zughaier et al.   PLoS One

Postinjury multiple organ failure

(2009) David Dewar et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points followingAspergillus fumigatusInfection

(2009) Monica M. Mircescu et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4

(2008) Janeen R. Jordan et al.   JOURNAL OF APPLIED PHYSIOLOGY