Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

(2017) Yusuke Ohno et al.   Nature Communications

Tear film lipid layer: A molecular level view

(2016) Lukasz Cwiklik   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

(2016) Akio Kihara   PROGRESS IN LIPID RESEARCH

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

(2015) Takuya Kitamura et al.   BIOCHEMICAL JOURNAL

Diquafosol Ophthalmic Solution 3 %: A Review of Its Use in Dry Eye

(2015) Gillian M. Keating   DRUGS

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

(2015) Yusuke Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

(2014) Takayuki Sassa et al.   Biomolecules & Therapeutics

Efficacy of Hypotonic 0.18% Sodium Hyaluronate Eye Drops in Patients With Dry Eye Disease

(2014) Hyo Seok Lee et al.   CORNEA

Rethinking Dry Eye Disease: A Perspective on Clinical Implications

(2014) Anthony J. Bron et al.   Ocular Surface

Tear film lipids

(2013) Igor A. Butovich   EXPERIMENTAL EYE RESEARCH

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

(2013) T. Sassa et al.   MOLECULAR AND CELLULAR BIOLOGY

Very long-chain fatty acids: elongation, physiology and related disorders

(2012) A. Kihara   JOURNAL OF BIOCHEMISTRY

Meibum Lipid Composition in Asians with Dry Eye Disease

(2011) Sin Man Lam et al.   PLoS One

Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry

(2010) Emanuela Camera et al.   JOURNAL OF LIPID RESEARCH

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

(2010) Y. Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA