Current challenges for cancer vaccine adjuvant development

COX-2 inhibitor prevents tumor induced down regulation of classical DC lineage specific transcription factor Zbtb46 resulting in immunocompetent DC and decreased tumor burden

(2017) Vipul K. Pandey et al.   IMMUNOLOGY LETTERS

Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence

(2017) Mari F.C.M. van den Hout et al.   Cancer Immunology Research

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

(2017) Margherita Coccia et al.   npj Vaccines

TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

(2016) Paul F. McKay et al.   PLoS One

Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant

(2016) Anna U. Bielinska et al.   VACCINE

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

(2016) Fabian Flores-Borja et al.   Journal of Immunology Research

Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists

(2015) Martin Kreutz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microenvironment abnormalities and lymphomagenesis: Immunological aspects

(2015) Joseph G. Taylor et al.   SEMINARS IN CANCER BIOLOGY

ISCOMATRIX™ adjuvant promotes epitope spreading and antibody affinity maturation of influenza A H7N9 virus like particle vaccine that correlate with virus neutralization in humans

(2015) Ka Yan Chung et al.   VACCINE

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

SA-4-1BBL and Monophosphoryl Lipid A Constitute an Efficacious Combination Adjuvant for Cancer Vaccines

(2014) A. K. Srivastava et al.   CANCER RESEARCH

SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines

(2014) Rajesh K Sharma et al.   Expert Review of Vaccines

ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

(2014) M. Schnurr et al.   JOURNAL OF IMMUNOLOGY

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Adjuvants and myeloid-derived suppressor cells: Enemies or allies in therapeutic cancer vaccination

(2014) Audry Fernández et al.   Human Vaccines & Immunotherapeutics

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

(2014) By Zhao et al.   Journal for ImmunoTherapy of Cancer

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

(2013) Joseph G. Crompton et al.   IMMUNOLOGICAL REVIEWS

Immune system targeting by biodegradable nanoparticles for cancer vaccines

(2013) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer

(2013) Satoshi Wada et al.   Journal of Translational Medicine

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD4+ T Cells Play a Critical Role in the Generation of Primary and Memory Antitumor Immune Responses Elicited by SA-4-1BBL and TAA-Based Vaccines in Mouse Tumor Models

(2013) Rajesh K. Sharma et al.   PLoS One

Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines

(2013) Haval Shirwan et al.   OncoImmunology

Mining the mutanome: developing highly personalized Immunotherapies based on mutational analysis of tumors

(2013) Willem W Overwijk et al.   Journal for ImmunoTherapy of Cancer

PD-1-Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

(2012) C. Badoual et al.   CANCER RESEARCH

MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice

(2012) Ming Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4+ T Cells into CD4+FoxP3+ T Regulatory Cells by Production of IFN-γ

(2012) Shravan Madireddi et al.   PLoS One

Prime-Boost Vaccination with SA-4-1BBL Costimulatory Molecule and Survivin Eradicates Lung Carcinoma in CD8+ T and NK Cell Dependent Manner

(2012) Abhishek K. Srivastava et al.   PLoS One

Comparison of the immune responses to the CIA06-adjuvanted human papillomavirus L1 VLP vaccine with those against the licensed HPV vaccine Cervarix™ in mice

(2012) Ji Eun Han et al.   VACCINE

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+dendritic cells

(2012) Masahiro Azuma et al.   OncoImmunology

CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: three cases

(2011) Jianda Yuan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bacterial ghosts as carriers of protein subunit and DNA-encoded antigens for vaccine applications

(2011) Abbas Muhammad et al.   Expert Review of Vaccines

ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway

(2011) Nicholas S Wilson et al.   IMMUNOLOGY AND CELL BIOLOGY

Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application

(2011) Paolo A Ascierto et al.   Journal of Translational Medicine

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

(2011) M. K. L. MacLeod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4-1BB Ligand as an Effective Multifunctional Immunomodulator and Antigen Delivery Vehicle for the Development of Therapeutic Cancer Vaccines

(2010) R. K. Sharma et al.   CANCER RESEARCH

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques

(2010) M. P. Morrow et al.   Clinical and Vaccine Immunology

Induction of T cell anergy: integration of environmental cues and infectious tolerance

(2010) Pascal Chappert et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

ISCOMATRIX™ vaccines: Safety in human clinical studies

(2010) Andrew McKenzie et al.   Human vaccines & immunotherapeutics

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Lympho-geographical concepts in vaccine delivery

(2010) Pål Johansen et al.   JOURNAL OF CONTROLLED RELEASE

Versatile Virus-Like Particle Carrier for Epitope Based Vaccines

(2010) Alain C. Tissot et al.   PLoS One

Adjuvants for cancer vaccines

(2010) Thomas W. Dubensky et al.   SEMINARS IN IMMUNOLOGY

Costimulation as a Platform for the Development of Vaccines: A Peptide-Based Vaccine Containing a Novel Form of 4-1BB Ligand Eradicates Established Tumors

(2009) R. K. Sharma et al.   CANCER RESEARCH

ProtEx™ technology for the generation of novel therapeutic cancer vaccines

(2009) Rich-Henry Schabowsky et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression

(2009) Matthew R. Farren et al.   IMMUNOLOGIC RESEARCH

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

CL097, A TLR7/8 LIGAND, INHIBITS TLR-4-DEPENDENT ACTIVATION OF IRAK-M AND BCL-3 EXPRESSION

(2009) Branka Petricevic et al.   SHOCK

The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells

(2008) Johanna Kober et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heat shock protein derivatives for delivery of antigens to antigen presenting cells

(2007) Makiya Nishikawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS