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Title
An overview of hypocretin based therapy in narcolepsy
Authors
Keywords
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Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 27, Issue 4, Pages 389-406
Publisher
Informa UK Limited
Online
2018-04-06
DOI
10.1080/13543784.2018.1459561
References
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Note: Only part of the references are listed.- Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models
- (2017) Yoko Irukayama-Tomobe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 0641 A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, 12-WEEK, MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF JZP-110 FOR THE TREATMENT OF EXCESSIVE SLEEPINESS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
- (2017) PK Schweitzer et al. SLEEP
- 0668 EVALUATION OF COMMERCIAL RIA AND ELISA FOR MEASURING CSF OREXIN-A (HYPOCRETIN-1)
- (2017) T Ono SLEEP
- Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice
- (2017) Panagis Drakatos et al. SLEEP MEDICINE
- iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells
- (2017) Songjie Cai et al. Stem Cell Reports
- 0641 A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, 12-WEEK, MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF JZP-110 FOR THE TREATMENT OF EXCESSIVE SLEEPINESS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
- (2017) PK Schweitzer et al. SLEEP
- 0668 EVALUATION OF COMMERCIAL RIA AND ELISA FOR MEASURING CSF OREXIN-A (HYPOCRETIN-1)
- (2017) T Ono SLEEP
- Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset
- (2017) Adi Aran et al. SLEEP
- Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy
- (2017) Thomas C. Thannickal et al. SLEEP
- Anti-Tribbles Homolog 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
- (2017) Minae Kawashima et al. SLEEP
- A Practical Approach to Excessive Daytime Sleepiness: A Focused Review
- (2016) Brian J. Murray Canadian Respiratory Journal
- Orexin gene transfer into the amygdala suppresses both spontaneous and emotion-induced cataplexy in orexin-knockout mice
- (2016) Meng Liu et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
- (2016) Jie Yin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor
- (2016) Patrick Aldrin-Kirk et al. NEURON
- Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b Study
- (2016) Chad Ruoff et al. SLEEP
- Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
- (2016) Jie Yin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid
- (2016) Christophe Hirtz et al. Scientific Reports
- Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b Study
- (2016) Chad Ruoff et al. SLEEP
- Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells
- (2015) F. T. Merkle et al. DEVELOPMENT
- Differentiation of hypothalamic-like neurons from human pluripotent stem cells
- (2015) Liheng Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases
- (2015) A. Ambati et al. JOURNAL OF INTERNAL MEDICINE
- Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
- (2015) Takashi Nagahara et al. JOURNAL OF MEDICINAL CHEMISTRY
- Narcolepsy
- (2015) Thomas E. Scammell NEW ENGLAND JOURNAL OF MEDICINE
- Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
- (2015) Syed Sohail Ahmed et al. Science Translational Medicine
- Anatomy and physiology of the blood–brain barrier
- (2015) Yonatan Serlin et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Effect of oral JZP-110 (ADX-N05) treatment on wakefulness and sleepiness in adults with narcolepsy
- (2015) Richard K. Bogan et al. SLEEP MEDICINE
- The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy
- (2014) Sara Lena Weinhold et al. BEHAVIOURAL BRAIN RESEARCH
- Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in England
- (2014) Anne Marie Winstone et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010
- (2014) D O’Flanagan et al. Eurosurveillance
- Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics
- (2014) Danica B Stanimirovic et al. Expert Opinion on Drug Discovery
- Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: What is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants
- (2014) S. Sohail Ahmed et al. JOURNAL OF AUTOIMMUNITY
- CSF beta-amyloid levels are altered in narcolepsy: a link with the inflammatory hypothesis?
- (2014) Claudio Liguori et al. JOURNAL OF SLEEP RESEARCH
- Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
- (2014) Markku Partinen et al. LANCET NEUROLOGY
- Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States
- (2014) J. Duffy et al. NEUROLOGY
- Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle
- (2014) Jens Niewoehner et al. NEURON
- Effects of Hypocretin/Orexin Cell Transplantation on Narcoleptic-Like Sleep Behavior in Rats
- (2014) Oscar Arias-Carrión et al. PLoS One
- Risk of Narcolepsy Associated with Inactivated Adjuvanted (AS03) A/H1N1 (2009) Pandemic Influenza Vaccine in Quebec
- (2014) Jacques Montplaisir et al. PLoS One
- Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France
- (2013) Yves Dauvilliers et al. BRAIN
- The autoimmune basis of narcolepsy
- (2013) Josh Mahlios et al. CURRENT OPINION IN NEUROBIOLOGY
- Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells
- (2013) Koji Hayakawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
- (2013) Yves Dauvilliers et al. LANCET NEUROLOGY
- Cerebrospinal Fluid Melanin-Concentrating Hormone (MCH) and Hypocretin-1 (HCRT-1, Orexin-A) in Alzheimer’s Disease
- (2013) Frank M. Schmidt et al. PLoS One
- Differences in Brain Morphological Findings between Narcolepsy with and without Cataplexy
- (2013) Masaki Nakamura et al. PLoS One
- Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier
- (2013) D. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice
- (2013) Sandor Kantor et al. SLEEP
- Effects of Orexin Gene Transfer in the Dorsolateral Pons in Orexin Knockout Mice
- (2013) Carlos Blanco-Centurion et al. SLEEP
- Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease
- (2013) Zinovia Kefalopoulou et al. JAMA Neurology
- Intranasal Administration of CNS Therapeutics to Awake Mice
- (2013) Leah R. Hanson et al. Jove-Journal of Visualized Experiments
- MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity
- (2013) Sue Tsai et al. Frontiers in Immunology
- Drug Transport across the Blood–Brain Barrier
- (2012) William M Pardridge JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency
- (2012) S. Knudsen et al. NEUROLOGY
- Control of Sleep and Wakefulness
- (2012) Ritchie E. Brown et al. PHYSIOLOGICAL REVIEWS
- Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland
- (2012) Markku Partinen et al. PLoS One
- AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland
- (2012) Hanna Nohynek et al. PLoS One
- Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china
- (2011) Fang Han et al. ANNALS OF NEUROLOGY
- Recent Advances in the Treatment of Narcolepsy
- (2011) Nobuhide Hirai et al. Current Treatment Options in Neurology
- Orexin Gene Transfer into Zona Incerta Neurons Suppresses Muscle Paralysis in Narcoleptic Mice
- (2011) M. Liu et al. JOURNAL OF NEUROSCIENCE
- Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep
- (2011) M. Mieda et al. JOURNAL OF NEUROSCIENCE
- A remarkable effect of alemtuzumab in a patient suffering from narcolepsy with cataplexy
- (2011) Claire E. H. M. Donjacour et al. JOURNAL OF SLEEP RESEARCH
- Intravenous Immunoglobulin Treatment and Screening for Hypocretin Neuron-Specific Autoantibodies in Recent Onset Childhood Narcolepsy with Cataplexy
- (2011) S. Knudsen et al. NEUROPEDIATRICS
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy
- (2011) P.C. Baier et al. SLEEP MEDICINE
- Cell Transplantation: A Future Therapy for Narcolepsy?
- (2009) Oscar Arias-Carrion et al. CNS & Neurological Disorders-Drug Targets
- Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment
- (2009) Y. Dauvilliers et al. NEUROLOGY
- Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
- (2008) Meng Liu et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy
- (2008) P. O. Valko et al. JOURNAL OF NEUROLOGY
- Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy
- (2008) Giuseppe Plazzi et al. JOURNAL OF NEUROLOGY
- Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system
- (2008) Shyeilla V. Dhuria et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Novel Vasoconstrictor Formulation to Enhance Intranasal Targeting of Neuropeptide Therapeutics to the Central Nervous System
- (2008) S. V. Dhuria et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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