Article
Multidisciplinary Sciences
Nichola J. Starr, Mohammed H. Khan, Max K. Edney, Gustavo F. Trindade, Stefanie Kern, Alexander Pirkl, Matthias Kleine-Boymann, Christopher Elms, Mark M. O'Mahony, Mike Bell, Morgan R. Alexander, David J. Scurr
Summary: In this study, the 3D OrbiSIMS technique was used to analyze the molecular chemistry of human skin tissue and provide unprecedented details about the nonhomogeneity of the stratum corneum. The analysis resolved debates about chemical gradients within the epidermis and revealed similarities in epidermal compounds between human and porcine skin. Additionally, the study demonstrated the permeation of an antiaging peptide into the human stratum corneum.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Joke A. Bouwstra, Andreea Nadaban, Wim Bras, Clare McCabe, Annette Bunge, Gerrit S. Gooris
Summary: The barrier function of the skin is primarily located in the outermost layer called stratum corneum (SC), which contains lipid lamellae that play a crucial role in permeation of compounds. Analyzing the lipid composition is essential in understanding the skin barrier function and its impairment in inflammatory skin diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Arya Kadukkattil Ramanunny, Sheetu Wadhwa, Monica Gulati, Sachin Kumar Singh, Bhupinder Kapoor, Harish Dureja, Dinesh Kumar Chellappan, Krishnan Anand, Kamal Dua, Rubiya Khursheed, Ankit Awasthi, Rajan Kumar, Jaskiran Kaur, Leander Corrie, Narendra Kumar Pandey
Summary: Skin diseases are a significant burden on the global economy and affect patients' quality of life. Traditional treatment approaches face limitations, but nanomedicine offers efficient targeted drug delivery solutions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiun-Wen Guo, Shiou-Hwa Jee
Summary: The treatment of inflammatory skin diseases poses challenges, with topical therapy being the first line of management. The key to success lies in the effectiveness and adaptability of the pharmaceutical formulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Claudio Malnati, Daniel Fehr, Fabrizio Spano, Mathias Bonmarin
Summary: The research suggests that skin capacitance decreases at high hydration levels, emphasizing the importance of variations in stratum corneum thickness for hydration monitoring. Additionally, the sensitivity to stratum corneum hydration levels is influenced by the electrode's geometry and dimensions, with conductance electrodes being more affected by changes in dimension than capacitance electrodes.
Article
Biochemistry & Molecular Biology
Jee-hyun Hwang, Haengdueng Jeong, Nahyun Lee, Sumin Hur, Nakyum Lee, Jeong Jun Han, Hye Won Jang, Wang Keun Choi, Ki Taek Nam, Kyung-Min Lim
Summary: The study found that the ex vivo live full-thickness porcine skin model is an excellent alternative to animal experiments for research on the safety and efficacy of cosmetic ingredients. Lactobionic acid showed the best improvement in skin barrier function, and the model could measure TEWL, confirming the significant skin barrier-protective effects of PHAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi
Summary: Insulin is commonly delivered through subcutaneous injections for the treatment of diabetes, which can be invasive and hinder patient compliance. Transdermal delivery methods, such as microneedles and patches, offer advantages including prolonged drug release and improved patient adherence. Research in transdermal insulin delivery is ongoing, and it is expected that these systems may soon be introduced in clinical practice.
Article
Pharmacology & Pharmacy
V. H. P. Infante, P. M. B. G. Maia Campos, L. S. Calixto, M. E. Darvin, M. Kroeger, S. Schanzer, S. B. Lohan, J. Lademann, M. C. Meinke
Summary: The study evaluated and compared the rheological behavior and texture profile of two sunscreen formulations and correlated them with their SPF values, finding that the formulation with ethoxylated lanolin showed better efficacy and positive influence on skin surface deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Polymer Science
Martin Juhascik, Andrej Kovacik, Gloria Huerta-Angeles
Summary: Hyaluronan (HA) plays a crucial role in maintaining skin health, studying skin inflammatory diseases, and delivering skin drugs, with the molecular size being a significant factor in mechanisms and interactions.
Article
Biochemistry & Molecular Biology
Mariola M. Blaszczyk, Jerzy P. Sek
Summary: Nanoparticles are efficient carriers of medicals, cosmetics, and pharmaceuticals. This study proposes a new model to predict the transport of nanoparticles through the stratum corneum. The modeling of diffusion processes of nanoparticles in a capillary provides an efficient approach to determine the transport phenomena through the skin layer.
Review
Medicine, Research & Experimental
Fei Qu, Rui Geng, Yijing Liu, Jintao Zhu
Summary: Skin diseases have a significant impact on patients' quality of life and the global economy. Advanced transdermal drug delivery strategies, such as nanocarrier and microneedle-based systems, offer efficient and targeted drug delivery with reduced side effects and improved functions.
Article
Chemistry, Multidisciplinary
Xiaoyan Sun, Jiangbing Xiang, Runkai Chen, Zhijun Geng, Lintao Wang, Yiqiong Liu, Shuaifei Ji, Huating Chen, Yan Li, Cuiping Zhang, Peng Liu, Tao Yue, Lei Dong, Xiaobing Fu
Summary: The research introduces a practical strategy for engineering functional human sweat glands via cell reprogramming and organoid technology. The successful regeneration of functional sweat glands in vitro and in vivo highlights the translational potential for personalized sweat gland regeneration in patients with extensive skin defects.
Article
Pharmacology & Pharmacy
Konstantin Simon, Gila Oberender, Alexander Roloff
Summary: Tape stripping is a common method used in studies on drug penetration through the skin, but the amount of stratum corneum removed by each tape strip is still under debate. Some studies suggest that the amount of stratum corneum decreases with increasing depth, while others find a constant removal rate.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Article
Chemistry, Multidisciplinary
Takayuki Imoto, Masahiro Goto
Summary: The study analyzed the self-assembled structure of Pal-GH and confirmed its effectiveness as a permeation enhancer, finding that it does not disrupt the skin structure when permeating the stratum corneum.
Article
Dermatology
Tomoya Nakamura, Akiko Nishibu, Naoki Yoshida, Mitsue Yasoshima, Kazushi Anzawa, Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu, Kazuo Ogawa, Takashi Mochizuki
EXPERIMENTAL DERMATOLOGY
(2016)
Article
Endocrinology & Metabolism
Yasuharu Watanabe, Tomoya Nakamura, Sho Ishikawa, Shiho Fujisaka, Isao Usui, Koichi Tsuneyama, Yoshinori Ichihara, Tsutomu Wada, Yoichiro Hirata, Takayoshi Suganami, Hirofumi Izaki, Shizuo Akira, Kensuke Miyake, Hiro-omi Kanayama, Michio Shimabukuro, Masataka Sata, Toshiyasu Sasaoka, Yoshihiro Ogawa, Kazuyuki Tobe, Kiyoshi Takatsu, Yoshinori Nagai
Article
Dermatology
Tomoya Nakamura, Akiko Nishibu, Mitsue Yasoshima, Chiaki Tanoue, Naoki Yoshida, Junko Hatta, Takayuki Miyamoto, Masahiro Nishii, Tsutomu Yanagibashi, Yoshinori Nagai, Kiyoshi Takatsu, Takashi Mochizuki, Kazuo Ogawa
JOURNAL OF DERMATOLOGICAL SCIENCE
(2012)
Review
Mycology
Tomoya Nakamura, Naoki Yoshida, Akiko Nishibu, Takashi Mochizuki
MEDICAL MYCOLOGY JOURNAL
(2019)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
