Article
Oncology
Ryotaro Kondo, Naoya Sakamoto, Kenji Harada, Hiroko Hashimoto, Ryo Morisue, Kazuyoshi Yanagihara, Takahiro Kinoshita, Motohiro Kojima, Genichiro Ishii
Summary: This study investigated the invasive modes of gastric cancer cells in the presence of cancer-associated fibroblasts (CAFs), and found that gastric cancer cells exhibit both CAF-dependent and -independent modes of invasion, which are determined by intrinsic factors of the cancer cells. By modifying the invasive capacity of CAFs, the invasive mode of gastric cancer cells can be altered.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sarah F. Stuart, Ayenachew Bezawork-Geleta, Zammam Areeb, Juliana Gomez, Vanessa Tsui, Ahmad Zulkifli, Lucia Paradiso, Jordan Jones, Hong P. T. Nguyen, Tracy L. Putoczki, Paul V. Licciardi, George Kannourakis, Andrew P. Morokoff, Adrian A. Achuthan, Rodney B. Luwor
Summary: In this study, it was found that the IL-11/IL-11R alpha pathway promotes survival, migration, and invasion of glioblastoma cells in glucose-starved conditions through glutaminolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hee Ja Kim, Kyungwon Yang, Kiyoon Kim, Ye-Ji Lee, Sieun Lee, Sung Yong Ahn, Young-Ho Ahn, Jihee Lee Kang
Summary: The interaction between apoptotic cancer cells and CAFs can inhibit migration and invasion of cancer cells and CAFs, thereby preventing cancer progression and metastasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Jinli Ding, Chaogang Yang, Yanxiang Cheng, Jiayu Wang, Sainan Zhang, Sisi Yan, Fan He, Tailang Yin, Jing Yang
Summary: The study demonstrates that trophoblasts induce M2 macrophages polarization via the IL-6/Stat3 signaling pathway, thereby promoting trophoblast invasion and migration. These results reveal the interaction between macrophages and trophoblasts in the maternal-fetal microenvironment during normal pregnancy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Hua Ma, Zhihui He, Jing Chen, Xu Zhang, Pingping Song
Summary: This study identified 11 hub genes associated with gastric cancer, with functions enriched in cellular senescence, cell cycle, viral carcinogenesis, and the p53 signaling pathway. Ten of these genes were found to be related to overall survival in GC patients, and seven were significantly correlated with GC, potentially serving as prognostic biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lydia Koch, Birte Kespohl, Maria Agthe, Tim Schumertl, Stefan Dusterhoft, Marius K. Lemberg, Juliane Lokau, Christoph Garbers
Summary: Interleukin-11 (IL-11) activates target cells through different signaling pathways, including the shedding of IL-11R triggered by RHBDL2. RHBDL2 can cleave IL-11R within the cell, generating biologically active sIL-11R capable of trans-signaling IL-11 action.
Article
Cell Biology
Zongwen Liang, Qiong Wu, Honglin Wang, Jiahuan Tan, Han Wang, Yanling Gou, Yingying Cao, Zhi Li, Zongfeng Zhang
Summary: This study found that MALAT1 knockdown could promote ferroptosis upon Erastin treatment through regulating the miR-145-5p/MUC1 signaling pathway, suggesting a potential therapeutic strategy for endometriosis.
CELL DEATH DISCOVERY
(2022)
Article
Multidisciplinary Sciences
Laura Wiggins, Alice Lord, Killian L. Murphy, Stuart E. Lacy, Peter J. O'Toole, William J. Brackenbury, Julie Wilson
Summary: CellPhe is a pattern recognition toolkit that enables unbiased characterization of cellular phenotypes within time-lapse videos. It imports tracking information from multiple algorithms and provides automated recognition and removal of erroneous cell boundaries. It also offers a variety of feature selection and classification algorithms.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Anibal Mendez-Clemente, Alejandro Bravo-Cuellar, Salvador Gonzalez-Ochoa, Maria Santiago-Mercado, Luis Palafox-Mariscal, Luis Jave-Suarez, Fabiola Solorzano-Ibarra, Maria Villasenor-Garcia, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores
Summary: This study investigated the effect of inhibiting the STAT-3 pathway on metastatic prostate cancer cells and found that the combination of Stattic and Tocilizumab can reduce the invasive and migratory abilities of the cells. Additionally, the study found that IL-6 plays an important role in regulating the metastasis process of prostate cancer.
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Article
Neurosciences
Jing Zhong, Weiran Shan, Zhiyi Zuo
Summary: The study found that norepinephrine can effectively inhibit the migration and invasion of human glioblastoma cells, possibly by decreasing the expression of MMP-11. In U251 cells, beta-adrenergic receptor may regulate this effect.
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Jianfei Zhang, Qianqiao Guo, Guoxiang Zhang, Xuemei Cao, Wei Chen, Yong Li, Minwu Guan, Jianjun Yu, Xindong Wang, Yujin Yan
Summary: The expression of MYBPH is found to be highly associated with glioma aggressiveness and poor prognosis. This study establishes MYBPH as an important prognostic biomarker and suggests its potential as a therapeutic target.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Bu Wang, Fang Zou, Gu Xin, Bao-Li Xiang, Jian-Qing Zhao, Sheng-Fang Yuan, Xiu-Long Zhang, Zhi-Hua Zhang
Summary: This study found that sodium tanshinone IIA sulphate (STS) extracted from Salvia miltiorrhiza Bunge has an anti-tumor effect on lung adenocarcinoma, inhibiting cell proliferation, migration, invasion, and angiogenesis. This effect may be mediated by the miR-874/eEF-2K/TG2 pathway. STS could be a promising drug to fight against lung cancer and effectively reverse drug resistance when combined with classical anticancer drugs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiao Wang, Huijuan Xu, Yujie Song, Wenping Cao
Summary: This study investigated the role of TRIM27 in laryngeal cancer cells and the effects of IL-6 coupled with JAK-STAT signaling pathway on the pathogenesis of laryngeal cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medical Laboratory Technology
Jin Wang, Jinglei Qu, Zhi Li, Xiaofang Che, Jing Liu, Yuee Teng, Bo Jin, Mingfang Zhao, Yunpeng Liu, Xiujuan Qu
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Oncology
Wei Jing, Na Song, Yunpeng Liu, Xiujuan Qu, Kezuo Hou, Xianghong Yang, Xiaofang Che
MOLECULAR MEDICINE REPORTS
(2018)
Article
Oncology
Chenlu Zhang, Zhi Li, Ling Xu, Xiaofang Che, Ti Wen, Yibo Fan, Ce Li, Shuo Wang, Yu Cheng, Xiaoxun Wang, Xiujuan Qu, Yunpeng Liu
Article
Oncology
Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu, Yuee Teng
Article
Biochemistry & Molecular Biology
Shuo Wang, Ling Xu, Xiaofang Che, Ce Li, Lu Xu, Kezuo Hou, Yibo Fan, Ti Wen, Xiujuan Qu, Yunpeng Liu
Article
Oncology
Lu Xu, Xiaofang Che, Ying Wu, Na Song, Sha Shi, Shuo Wang, Ce Li, Lingyun Zhang, Xinlian Zhang, Xiujuan Qu, Yuee Teng
Article
Oncology
Yan Wang, Yongxi Song, Xiaofang Che, Lingyun Zhang, Qian Wang, Xiaomeng Zhang, Jinglei Qu, Zhi Li, Ling Xu, Ye Zhang, Yibo Fan, Kezuo Hou, Yunpeng Liu, Xiujuan Qu
Article
Oncology
Yu Cheng, Yongxi Song, Jinglei Qu, Xiaofang Che, Na Song, Yibo Fan, Ti Wen, Ling Xu, Jing Gong, Xiaoxun Wang, Chenlu Zhang, Xiujuan Qu, Yunpeng Liu
TRANSLATIONAL ONCOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xiaonan Shi, Libao Gong, Yunpeng Liu, Kezuo Hou, Yibo Fan, Ce Li, Ti Wen, Xiujuan Qu, Xiaofang Che
Article
Oncology
Na Song, Ming Bai, Xiaofang Che, Zhi Li, Wei Jing, Ce Li, Zan Teng, Xiujuan Qu, Yunpeng Liu
Article
Oncology
Mingming Deng, Bofang Liu, Zhe Zhang, Yang Chen, Yizhe Wang, Ximing Wang, Qingjie Lv, Xianghong Yang, Kezuo Hou, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Ye Zhang, Xuejun Hu
Review
Pharmacology & Pharmacy
Puxiu Wang, Xiujuan Qu, Xiaofang Che, Qiuhua Luo, Xing Tang, Yunpeng Liu
Summary: Despite showing promising potential in both mouse models and clinical trials, the clinical application of IP therapy for patients with PM is limited due to serious side effects and low acceptability. Further investigations, including pharmaceutical strategies, are needed to develop potential IP therapy solutions that focus on both efficacy and safety.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Oncology
Rui Ma, Yunpeng Liu, Xiaofang Che, Ce Li, Ti Wen, Kezuo Hou, Xiujuan Qu
Summary: Colorectal cancers with the BRAF V600E mutation have upregulated PD-L1 expression. This study found that PD-L1 is highly expressed in both the nucleus and cytoplasm. In the nucleus, PD-L1 translocation is facilitated by p-ERK and it interacts with THRAP3 to upregulate BUB1 expression, thus accelerating cell cycle progression and promoting cell proliferation. Additionally, BRAF V600E mutated CRC cells upregulate PD-L1 expression via the transcription factor LEF-1. These findings reveal a novel role of nPD-L1 in promoting cell cycle progression in an immune-independent manner in BRAF V600E mutated CRC.
Article
Cell Biology
Xiaonan Shi, Chunlei Zheng, Ce Li, Kezuo Hou, Xiaoxun Wang, Zichang Yang, Chang Liu, Yunpeng Liu, Xiaofang Che, Xiujuan Qu
CELL BIOLOGY INTERNATIONAL
(2018)
Article
Biology
S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2018)
