Article
Oncology
Megan M. Harper, Miranda Lin, Shadi A. Qasem, Reema A. Patel, Michael J. Cavnar, Prakash K. Pandalai, Mei Gao, Joseph Kim
Summary: This study describes a previously unreported mechanism of PD-1/MET interaction and the oncogenic functionality of PD-1 in pancreatic cancer. The researchers found that PD-1 can induce epithelial-to-mesenchymal transition (EMT) and regulate growth, migration, and invasion in pancreatic cancer cells. Targeting PD-1 and MET together resulted in substantial tumor cell cytotoxicity and growth inhibition. These findings highlight the importance of targeting the PD-1 axis in pancreatic cancer treatment.
Article
Oncology
Liangliang An, Yongqiang Liu
Summary: This study revealed the significant up-regulation of ZNF460 in gastric cancer, and its expression correlated with tumor grade, lymph node metastasis, and H. pylori infection. Functionally, diminished ZNF460 expression inhibited gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, and suppressed tumor growth in vivo. Mechanistically, ZNF460 combined with apolipoprotein C1 (APOC1) promoter to facilitate APOC1 transcription and accelerated EMT, thereby promoting gastric cancer progression.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Min Hee Yang, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Sang Hoon Jung, Hyejin Ko, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: Procaine inhibits the EMT process and c-Met-dependent signaling cascades, suggesting its potential as an anti-metastatic agent for HCC.
Article
Cell Biology
Wen Jia, Mohit Kumar Jolly, Herbert Levine
Summary: The epithelial-mesenchymal transition (EMT) is a crucial cellular process for wound healing, cancer metastasis, and embryonic development. Recent studies have shown that hybrid epithelial/mesenchymal states, possessing both epithelial and mesenchymal traits, play a significant role in cancer metastasis and resistance to therapies. NRF2 has been identified as a stabilizing factor for these hybrid states. This research incorporates a phenomenological epigenetic feedback effect into a computational model for EMT signaling and demonstrates its stabilizing effect on the hybrid state if NRF2 influences SNAIL at an epigenetic level.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Isabelle McMullen, Aaditya Narayan Saxena, Sudhanva Kalasapura Venugopal, Jason A. Somarelli, Mohit Kumar Jolly
Summary: Research shows that the transcription factor KLF4 can delay the onset of EMT by suppressing multiple EMT-TFs and promote a phenotypic shift towards a more epithelial state. KLF4 can also strengthen its influence on modulating EMT dynamics by inhibiting cell-state transitions at the epigenetic level.
Article
Medicine, Research & Experimental
Wei Zeng, Ze Ting Xing, Mei Yun Tan, Yan Wen Wu, Chun Yuan Zhang
Summary: Lidocaine inhibits the malignant behavior of gastric cancer cells by suppressing the c-Met/c-Src pathway, promoting cell apoptosis, and increasing sensitivity to cisplatin or 5-FU.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Genetics & Heredity
Ameng Shi, Ting Wang, Miao Jia, Lei Dong, Haitao Shi
Summary: The study revealed that the SDF-1/CXCR7 axis is crucial in promoting migration, invasion, and EMT in gastric cancer cells, suggesting that targeting CXCR7 suppression could be a potential strategy for inhibiting gastric cancer metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Xiao-Lu Ma, Yan-Yan Nie, Su-Hong Xie, Hui Zheng, Ying Tong, Yan-Chun Wang, Tian-Qing Yan, Xin Meng, Jia-Zhen Cao, Wei-Guo Tang, Lin Guo, Ren-Quan Lu
Summary: ASAP2 is highly expressed in HCC and predicts poor prognosis. Knocking down ASAP2 inhibits proliferation, migration, and invasion, while promoting apoptosis in HCC cells. ASAP2 promotes HCC cell growth and facilitates lung metastasis.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, Yi-Long Wu, Meiyu Geng, Jing Ai
Summary: SYK regulates cell plasticity and can help accurately stratify NSCLC patients with c-Met overexpression, regardless of MET alterations, expanding the population predicted to benefit from c-Met-targeted therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yaohui Wang, Xiang Li, Tiancheng Zhang, Fangyuan Li, Yuke Shen, Yani He, Qiang You, Yifan Zhang, Jing Zhai, Xuequan Yao, Lizong Shen
Summary: In gastric cancer, tumor-associated neutrophils (TANs) promote lymph node metastasis (LNM) through enhancing tumor cell invasiveness and epithelial-to-mesenchymal transition (EMT). The crosstalk between neutrophils and tumor cells is mediated by various signaling pathways including TGF beta 1, FAM3C, and JNK-ZEB1/Snail, and involves interaction of integrins alpha 6 beta 1 and alpha 6 beta 4 with CD151. Studies using tumor-bearing mice confirm the importance of neutrophils in gastric cancer tumorigenesis and invasiveness. Understanding the functional roles of TANs in promoting tumor invasion provides potential targets for developing strategies to prevent or treat LNM in gastric cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ik Cha, Jeeyun Lee, Woo Kyoung Jeong, Seung Tae Kim, Jae-Hun Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Seon Woo Kim, DongilW Choi
Summary: The study developed a predictive model for the epithelial-to-mesenchymal transition (EMT) subtype of gastric cancer using computed tomography (CT) images and known clinicopathologic variables. A nomogram was constructed for individualized estimation of EMT subtype, providing a useful screening tool for personalized medicine.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu
Summary: The study revealed that fluid shear stress facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, leading to the release of YAP from integrin beta subunit and subsequent activation of EMT-regulating transcription factor SNAI1 and expression of EMT-related genes. FSS-treated HepG2 cells exhibited significantly increased tumorigenesis and metastasis in vivo.
MOLECULAR ONCOLOGY
(2021)
Review
Microbiology
Dan Zou, Ling Xu, Heming Li, Yanju Ma, Yuehua Gong, Tianshu Guo, Zhitao Jing, Xiuying Xu, Ye Zhang
CRITICAL REVIEWS IN MICROBIOLOGY
(2019)
Article
Oncology
Yibo Fan, Xiaofang Che, Jinglei Qu, Kezuo Hou, Ti Wen, Zhi Li, Ce Li, Shuo Wang, Ling Xu, Yunpeng Liu, Xiujuan Qu
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Xiaonan Shi, Libao Gong, Yunpeng Liu, Kezuo Hou, Yibo Fan, Ce Li, Ti Wen, Xiujuan Qu, Xiaofang Che
Article
Plant Sciences
Mingming Deng, Bofang Liu, Huicong Song, Ruoxi Yu, Dan Zou, Yang Chen, Yanju Ma, Fei Lv, Ling Xu, Zhe Zhang, Qingjie Lv, Xianghong Yang, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Ye Zhang, Xuejun Hu
Article
Oncology
Na Song, Ming Bai, Xiaofang Che, Zhi Li, Wei Jing, Ce Li, Zan Teng, Xiujuan Qu, Yunpeng Liu
Article
Oncology
Mingming Deng, Bofang Liu, Zhe Zhang, Yang Chen, Yizhe Wang, Ximing Wang, Qingjie Lv, Xianghong Yang, Kezuo Hou, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Ye Zhang, Xuejun Hu
Article
Oncology
Jinqi Lv, Tianshu Guo, Xiujuan Qu, Xiaofang Che, Ce Li, Shuo Wang, Jing Gong, Peihong Wu, Yang Liu, Yunpeng Liu, Ling Xu
FRONTIERS IN ONCOLOGY
(2020)
Review
Pharmacology & Pharmacy
Puxiu Wang, Xiujuan Qu, Xiaofang Che, Qiuhua Luo, Xing Tang, Yunpeng Liu
Summary: Despite showing promising potential in both mouse models and clinical trials, the clinical application of IP therapy for patients with PM is limited due to serious side effects and low acceptability. Further investigations, including pharmaceutical strategies, are needed to develop potential IP therapy solutions that focus on both efficacy and safety.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Oncology
Shuairan Zhang, Yang Liu, Zihan Jiao, Zenan Li, Jin Wang, Ce Li, Xiujuan Qu, Ling Xu
Summary: This study identified seven independent prognostic factors of GSRCC and established corresponding nomogram models to help clinicians predict survival, showing good predictive value in comparison to the traditional AJCC staging system.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shuo Wang, Xiujuan Qu, Zhi Li, Xiaofang Che, Lili Cao, Xianghong Yang, Xuejun Hu, Ling Xu, Kezuo Hou, Yibo Fan, Ti Wen, Yunpeng Liu
Summary: The study revealed that PD-L1 in ADC and PD-1+ TILs in SCC respectively indicate T-cell function, playing a crucial role in prognosis determination. PD-L1 was considered an independent predictor of overall survival for ADC patients, while PD-1+ TILs were deemed a poor prognostic predictor in SCC patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Rui Ma, Yunpeng Liu, Xiaofang Che, Ce Li, Ti Wen, Kezuo Hou, Xiujuan Qu
Summary: Colorectal cancers with the BRAF V600E mutation have upregulated PD-L1 expression. This study found that PD-L1 is highly expressed in both the nucleus and cytoplasm. In the nucleus, PD-L1 translocation is facilitated by p-ERK and it interacts with THRAP3 to upregulate BUB1 expression, thus accelerating cell cycle progression and promoting cell proliferation. Additionally, BRAF V600E mutated CRC cells upregulate PD-L1 expression via the transcription factor LEF-1. These findings reveal a novel role of nPD-L1 in promoting cell cycle progression in an immune-independent manner in BRAF V600E mutated CRC.
Article
Cell Biology
Jinqi Lv, Simeng Zhang, Yang Liu, Ce Li, Tianshu Guo, Shuairan Zhang, Zenan Li, Zihan Jiao, Haina Sun, Ye Zhang, Ling Xu
Summary: This study demonstrates that NR2F1-AS1/miR-190a/PHLDB2 promotes the phosphorylation of AKT3 to induce EMT in GC cells, providing a comprehensive understanding of the underlying mechanism involved in the EMT process and the identification of new EMT markers in gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Education, Scientific Disciplines
Shuairan Zhang, Zhi Li, Hang Dong, Peihong Wu, Yang Liu, Tianshu Guo, Ce Li, Shuo Wang, Xiujuan Qu, Yunpeng Liu, Xiaofang Che, Ling Xu
Summary: The study identified 155 differentially expressed immune-related genes in patients with gastric cancer, with four genes closely associated with overall survival. These genes were found to be predictive of patient outcomes.
Article
Medicine, Research & Experimental
Jing Gong, Yongxi Song, Ling Xu, Xiaofang Che, Kezuo Hou, Tianshu Guo, Yu Cheng, Yunpeng Liu, Xiujuan Qu
MEDICAL SCIENCE MONITOR
(2020)
Article
Oncology
Xing Wan, Yongxi Song, Honghong Fang, Ling Xu, Xiaofang Che, Shuo Wang, Xiaomeng Zhang, Lingyun Zhang, Ce Li, Yibo Fan, Kezuo Hou, Zhi Li, Xueqing Wang, Yunpeng Liu, Xiujuan Qu
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)
