Insulin/IGF-1 enhances intestinal epithelial crypt proliferation through PI3K/Akt, and not ERK signaling in obese humans

Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells

(2017) Chi-Cheng Lu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity

(2017) Hirotsugu Yanai et al.   Scientific Reports

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations

(2015) Laurianne Van Landeghem et al.   FASEB JOURNAL

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Effects of insulin on human pancreatic cancer progression modeled in vitro

(2014) Michelle T Chan et al.   BMC CANCER

Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

(2014) Amanda T. Mah et al.   ENDOCRINOLOGY

Nutrient-induced intestinal adaption and its effect in obesity

(2014) Megan J. Dailey   PHYSIOLOGY & BEHAVIOR

Insulin Resistance Induced by Hyperinsulinemia Coincides with a Persistent Alteration at the Insulin Receptor Tyrosine Kinase Domain

(2014) Karyn J. Catalano et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

(2014) Ann-Marie Baker et al.   Cell Reports

Obesity and colorectal cancer

(2013) Marc Bardou et al.   GUT

Role of insulin resistance in endothelial dysfunction

(2013) Ranganath Muniyappa et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Small Intestinal Alterations in Severely Obese Hyperglycemic Subjects

(2010) Froukje J. Verdam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

(2008) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY