Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles

Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size

(2017) Annika Warnatsch et al.   IMMUNITY

Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells

(2017) Emmanuel Stephen-Victor et al.   JOURNAL OF INFECTIOUS DISEASES

The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall

(2017) Vishukumar Aimanianda et al.   mBio

Candida albicans Yeast, Pseudohyphal, and Hyphal Morphogenesis Differentially Affects Immune Recognition

(2017) Liliane Mukaremera et al.   Frontiers in Immunology

β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

(2017) Matthew J. Elder et al.   Frontiers in Immunology

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation

(2016) Anja Schmitt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Triggering Dectin-1-Pathway Alone Is Not Sufficient to Induce Cytokine Production by Murine Macrophages

(2016) Sarah Walachowski et al.   PLoS One

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

(2016) Prajwal Gurung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

(2016) Te-Chen Tzeng et al.   Cell Reports

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response toCandida albicans

(2015) Noelia Blanco-Menéndez et al.   JOURNAL OF IMMUNOLOGY

Trained immunity: A smart way to enhance innate immune defence

(2015) Jos W.M. van der Meer et al.   MOLECULAR IMMUNOLOGY

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

(2014) Nandita Bose et al.   GLYCOBIOLOGY

 -Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner

(2014) V. B. Shah et al.   JOURNAL OF IMMUNOLOGY

The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis

(2014) M. Rosas et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation

(2014) Judith M. Bain et al.   mBio

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment

(2013) Julie Bonhomme et al.   CURRENT OPINION IN MICROBIOLOGY

Novel Structural Features inCandida albicansHyphal Glucan Provide a Basis for Differential Innate Immune Recognition of HyphaeVersusYeast

(2013) Douglas W. Lowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

(2010) Rebecca A. Drummond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Internalization of Dectin-1 terminates induction of inflammatory responses

(2009) Patricia Hernanz-Falcón et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Influence of Mannan and Glucan on Complement Activation and C3 Binding by Candida albicans

(2009) G. M. Boxx et al.   INFECTION AND IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Cell Wall β-(1,6)-Glucan ofSaccharomyces cerevisiae

(2009) Vishukumar Aimanianda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Vav1 and PI3K are required for phagocytosis of β-glucan and subsequent superoxide generation by microglia

(2009) Vaibhav B. Shah et al.   MOLECULAR IMMUNOLOGY

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An integrated model of the recognition of Candida albicans by the innate immune system

(2007) Mihai G. Netea et al.   NATURE REVIEWS MICROBIOLOGY