Monoclonal antibody-mediated killing of tumour cells by neutrophils

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Granulocytes as modulators of dendritic cell function

(2017) Annelot Breedveld et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy

(2017) Christian Kellner et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

A Phase II Efficacy and Safety, Open-Label, Multicenter Study of Imprime PGG Injection in Combination With Cetuximab in Patients With Stage IV KRAS-Mutant Colorectal Cancer

(2016) Neil H. Segal et al.   Clinical Colorectal Cancer

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

(2016) Anissa S. H. Chan et al.   PLoS One

Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer

(2015) N. Gul et al.   CANCER RESEARCH

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

(2015) Stefan Lohse et al.   CANCER RESEARCH

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease

(2015) Esil Aleyd et al.   IMMUNOLOGICAL REVIEWS

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

(2015) M Jack Borrok et al.   mAbs

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

(2015) Saskia Meyer et al.   mAbs

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

(2015) Henry R. Hampton et al.   Nature Communications

IgGA: A “Cross-Isotype” Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions

(2014) William Kelton et al.   CHEMISTRY & BIOLOGY

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

(2014) Nuray Gül et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

IgA Enhances NETosis and Release of Neutrophil Extracellular Traps by Polymorphonuclear Cells via Fc  Receptor I

(2014) E. Aleyd et al.   JOURNAL OF IMMUNOLOGY

Neutrophils mediate antibody-induced antitumor effects in mice

(2013) M. Albanesi et al.   BLOOD

IgAEGFR antibodies mediate tumour killingin vivo

(2013) Peter Boross et al.   EMBO Molecular Medicine

Neutrophils as effector cells for antibody-based immunotherapy of cancer

(2013) Marjolein van Egmond et al.   SEMINARS IN CANCER BIOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Antibody-Based Immunotherapy of Cancer

(2012) Louis M. Weiner et al.   CELL

Enhanced FcαRI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells

(2012) Marielle A. Otten et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ofatumumab Is More Efficient than Rituximab in Lysing B Chronic Lymphocytic Leukemia Cells in Whole Blood and in Combination with Chemotherapy

(2012) L. Bologna et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy

(2011) P. Hubert et al.   CANCER RESEARCH

Targeting Fc RI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy

(2011) J. E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

(2011) S. Lohse et al.   JOURNAL OF IMMUNOLOGY

CD47-signal regulatory protein-  (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction

(2011) X. W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy

(2010) Gerben J. van der Bij et al.   JOURNAL OF HEPATOLOGY

Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models

(2010) William M. Siders et al.   LEUKEMIA & LYMPHOMA

Immunoglobulin A: FcαRI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4

(2009) Lydia van der Steen et al.   GASTROENTEROLOGY

Impact of FcγRIIa-FcγRIIIa Polymorphisms and KRAS Mutations on the Clinical Outcome of Patients With Metastatic Colorectal Cancer Treated With Cetuximab Plus Irinotecan

(2009) Frédéric Bibeau et al.   JOURNAL OF CLINICAL ONCOLOGY

Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage

(2009) Tanja Schneider-Merck et al.   JOURNAL OF IMMUNOLOGY

A Recombinant Bispecific Single-Chain Fragment Variable Specific for HLA Class II and Fc RI (CD89) Recruits Polymorphonuclear Neutrophils for Efficient Lysis of Malignant B Lymphoid Cells

(2009) Y. Guettinger et al.   JOURNAL OF IMMUNOLOGY

Effect of Yeast-derived β-glucan in Conjunction With Bevacizumab for the Treatment of Human Lung Adenocarcinoma in Subcutaneous and Orthotopic Xenograft Models

(2009) Wangjian Zhong et al.   JOURNAL OF IMMUNOTHERAPY

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

(2008) M. Peipp et al.   BLOOD

A Polymorphism in the Complement Component C1qA Correlates with Prolonged Response Following Rituximab Therapy of Follicular Lymphoma

(2008) E. Racila et al.   CLINICAL CANCER RESEARCH

Granulocyte-Macrophage Colony-Stimulating Factor Potentiates Rituximab in Patients With Relapsed Follicular Lymphoma: Results of a Phase II Study

(2008) Guillaume Cartron et al.   JOURNAL OF CLINICAL ONCOLOGY