A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

(2012) K. Balabanian et al.   BLOOD

A review on CXCR4/CXCL12 axis in oncology: No place to hide

(2012) Urszula M. Domanska et al.   EUROPEAN JOURNAL OF CANCER

Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry

(2012) Sarah Beaussant Cohen et al.   Orphanet Journal of Rare Diseases

Incidence, Clinical Spectrum, Risk Factors and Impact of HIV-Associated Immune Reconstitution Inflammatory Syndrome in South Africa

(2012) Lewis John Haddow et al.   PLoS One

The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

(2011) D. C. Dale et al.   BLOOD

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

(2011) D. H. McDermott et al.   BLOOD

Human Bone Marrow Hosts Polyfunctional Memory CD4+ and CD8+ T Cells with Close Contact to IL-15-Producing Cells

(2011) D. Herndler-Brandstetter et al.   JOURNAL OF IMMUNOLOGY

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients

(2010) L. Tassone et al.   BLOOD

A Pivotal Role for CXCL12 Signaling in HPV-Mediated Transformation of Keratinocytes: Clues to Understanding HPV-Pathogenesis in WHIM Syndrome

(2010) Ken Y.C. Chow et al.   Cell Host & Microbe

Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndrome

(2010) Peter J. Mc Guire et al.   CLINICAL IMMUNOLOGY

AMD3100 is a potent antagonist at CXCR4R334X, a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

(2010) David H. McDermott et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization

(2009) M J Dugan et al.   BONE MARROW TRANSPLANTATION

Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow

(2009) Koji Tokoyoda et al.   IMMUNITY

Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma

(2009) John F. DiPersio et al.   JOURNAL OF CLINICAL ONCOLOGY

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

(2009) Peter J. McCormick et al.   PLoS One

WHIM syndrome: congenital immune deficiency disease

(2008) Toshinao Kawai et al.   CURRENT OPINION IN HEMATOLOGY