期刊
EXTRACELLULAR VESICLES AND MECHANISMS OF CELL-CELL COMMUNICATION
卷 62, 期 2, 页码 125-133出版社
PORTLAND PRESS LTD
DOI: 10.1042/EBC20170078
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资金
- NCI NIH HHS [R01 CA115316] Funding Source: Medline
- NIAID NIH HHS [R01 AI052439] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA115316] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052439] Funding Source: NIH RePORTER
EV (extracellular vesicle) biology is a rapidly expanding field. These heterogeneous membrane vesicles, which are shed from virtually all cell types, collectively represent a new dimension of intercellular communication in normal physiology and disease. They have been shown to deliver infectious and pathogenic agents to non-infected cells whereas in cancers they are thought to condition the tumor microenvironment. Their presence in body fluids and inherent capacity for systemic delivery point to their clinical promise. All of the above only intensifies the need to better understand the classification, mode of biogenesis, and contents of the different subtypes of EVs. This article focusses on vesicle subtypes labeled as exosomes and MVs (microvesicles) and discusses the biogenesis and release of these vesicles from cells.
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