The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

(2015) Cristina Espinosa-Diez et al.   ANTIOXIDANTS & REDOX SIGNALING

Toward Understanding Induction of Oxidative Stress and Apoptosis by Proteasome Inhibitors

(2014) Guillem Paniagua Soriano et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer

(2014) A. Pal et al.   CANCER RESEARCH

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner

(2013) C. Ravuri et al.   FREE RADICAL RESEARCH

Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression

(2013) Seila Pandur et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition

(2012) Marc Kästle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the Ubiquitin+Proteasome System in Solid Tumors

(2012) James J. Driscoll et al.   SEMINARS IN HEMATOLOGY

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Proteasome Inhibition Induces a p38 MAPK Pathway-Dependent Antiapoptotic Program via Nrf2 in Thyroid Cancer Cells

(2011) Zhen-Xian Du et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells

(2010) Xiang Wu et al.   BMC CANCER

Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease

(2010) Fawzia Bardag-Gorce et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Regulation of γ-Glutamyl Transpeptidase

(2009) Hongqiao Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death

(2009) Sergio Perez-Alvarez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Degradation of cAMP-Responsive Element-Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in  -Cells and Human Pancreatic Islets

(2009) S. Costes et al.   DIABETES

Signaling pathways involved in phase II gene induction by α, β-unsaturated aldehydes

(2009) Hongqiao Zhang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Proteasome inhibitors induce osteoclast survival by activating the Akt pathway

(2008) Han Bok Kwak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor α induces γ-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

(2008) Christopher C. Franklin et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE