Review
Biochemistry & Molecular Biology
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc
Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Ricardo Usategui-Martin, Kevin Puertas-Neyra, Nadia Galindo-Cabello, Leticia A. Hernandez-Rodriguez, Fernando Gonzalez-Perez, Jose Carlos Rodriguez-Cabello, Rogelio Gonzalez-Sarmiento, Jose Carlos Pastor, Ivan Fernandez-Bueno
Summary: This study evaluated the neuroprotective capability of the secretome of human bone marrow MSCs and found that it can slow retinal neurodegeneration by activating antioxidant machinery, modulating autophagy, and inhibiting apoptosis and necroptosis. The secretome of bmMSCs may be a potential therapeutic option for treating retinal neurodegenerative diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jan Spaas, Lieve van Veggel, Melissa Schepers, Assia Tiane, Jack van Horssen, David M. Wilson, Pablo R. Moya, Elisabeth Piccart, Niels Hellings, Bert O. Eijnde, Wim Derave, Rudy Schreiber, Tim Vanmierlo
Summary: Oligodendrocyte precursor cells (OPCs) play a crucial role in various neurodegenerative disorders, with oxidative/carbonyl stress potentially impacting their differentiation and function, contributing to disease progression. Investigating how oxidative/carbonyl stress disrupts OPC differentiation may offer new directions for therapeutic strategies in neurodegenerative disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Nutrition & Dietetics
Annamaria D'Alessandro, Giovina Di Felice, Melania Manco, Anna Pastore, Simona Pezzi, Michela Mariani, Danilo Fintini, Andrea Onetti Muda, Ottavia Porzio
Summary: Obesity is a serious public health challenge that is closely linked to oxidative stress and metabolic disorders. This study analyzed serum samples from children with obesity and found abnormal levels of oxidative stress markers, which were positively correlated with obesity-related indices. Age was also found to be associated with oxidative stress.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Biochemistry & Molecular Biology
Xin Shi, Panpan Li, Hanhan Liu, Verena Prokosch
Summary: This article reviews the impact of oxidative stress (OS) on endothelial dysfunction (ED) in the retina and explores the mechanistic links between the two and their role in different retinal neurodegenerative diseases. Understanding the role of endothelial function may lead to new therapeutic approaches.
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Kamil Kosmider, Maciej Kamieniak, Stanislaw J. Czuczwar, Barbara Miziak
Summary: Epilepsy is a chronic disease that causes recurrent seizures due to excessive oxidants formed during epileptic seizures. This review examines the relationship between newer antiepileptic drugs and oxidative stress. It suggests that drugs enhancing GABA-ergic transmission or other antiepileptics can reduce neuronal oxidation markers, but high doses of GABA-enhancing drugs may increase oxidative stress. Additionally, diazepam has a neuroprotective effect in a U-shaped dose-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Francesco D'Egidio, Vanessa Castelli, Annamaria Cimini, Michele d'Angelo
Summary: Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant huntingtin (Htt) protein. The accumulation of mutant protein leads to neuronal dysfunction and cell death, primarily through oxidative damage, excitotoxicity, inflammation, and mitochondrial impairment. This review aims to provide an overview of the cell's response to stress in HD, with a focus on the role of oxidative stress and its interaction with the antioxidant system.
Article
Biochemistry & Molecular Biology
Larissa E. van Eijk, Adriana Tami, Jan-Luuk Hillebrands, Wilfred F. A. den Dunnen, Martin H. de Borst, Peter H. J. van der Voort, Marian L. C. Bulthuis, Alida C. M. Veloo, Karin I. Wold, Maria F. Vincenti Gonzalez, Bernardina T. F. van der Gun, Harry van Goor, Arno R. Bourgonje
Summary: Patients with COVID-19 show increased systemic oxidative stress compared to healthy controls, as evidenced by significantly lower serum free thiol concentrations. These free thiols are positively associated with albumin and negatively associated with CRP, demonstrating discriminative ability in differentiating COVID-19 patients from healthy individuals.
Article
Biochemistry & Molecular Biology
Alessandra Vezzoli, Simona Mrakic-Sposta, Cinzia Dellanoce, Michela Montorsi, Daniele Vietti, Maria Elena Ferrero
Summary: This study aimed to investigate the efficacy of an antioxidant treatment in multiple sclerosis (MS) patients. The results showed that patients with MS had abnormalities in oxidative stress, inflammation, and nitric oxide metabolism, while antioxidant capacity was significantly reduced. Antioxidant treatment significantly reduced inflammation and oxidative stress. This protective effect may be achieved by reducing the production of reactive oxygen species, increasing antioxidant capacity, and improving the status of reduced thiols.
Review
Biochemistry & Molecular Biology
German Plascencia-Villa, George Perry
Summary: Alzheimer's disease is a progressive brain disorder characterized by memory and thinking impairment, with various pathological features such as abnormal protein aggregates, synaptic dysfunction, and oxidative stress. Oxidative stress, often overlooked or considered a consequence of dementia, plays a crucial role in AD progression and neuronal death. Recognizing oxidative stress as a key factor in AD has led to the development of alternative therapeutic interventions and preventive strategies for this devastating neurodegenerative disease.
Review
Immunology
Yili Zhang, Xinyi Huang, Baoyu Qi, Chuanrui Sun, Kai Sun, Ning Liu, Liguo Zhu, Xu Wei
Summary: Ferroptosis plays a crucial role in musculoskeletal disorders and has potential as a treatment strategy. However, more research is needed to understand its toxicity to other organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ajit Ray, Maltesh Kambali, Vijayalakshmi Ravindranath
ANTIOXIDANTS & REDOX SIGNALING
(2016)
Article
Biochemistry & Molecular Biology
William M. Johnson, Marcin Golczak, Kyonhwan Choe, Pierce L. Curran, Olga Gorelenkova Miller, Chen Yao, Wenzhang Wang, Jiusheng Lin, Nicole M. Milkovic, Ajit Ray, Vijayalakshmi Ravindranath, Xiongwei Zhu, Mark A. Wilson, Amy L. Wilson-Delfosse, Shu G. Chen, John J. Mieyal
Meeting Abstract
Biochemistry & Molecular Biology
Latha Diwakar, Debajyoti Debajyoti Das, Reddy Peera Kommaddi, Ajit Ray, Siddharth Nanguneri, Deepak Nair, Vijayalakshmi Ravindranath
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Reddy Peera Kommaddi, Debajyoti Das, Ajit Ray, Eisha Shaw, Vijayalakshmi Ravindranath
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Aditi Verma, Ajit Ray, Smitha Karunakaran, Lalitha Durgadoss, Vijayalakshmi Ravindranath
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Neurosciences
Smitha Karunakaran, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M. Michel, Pico Caroni
NATURE NEUROSCIENCE
(2016)
Article
Neurosciences
Reddy Peera Kommaddi, Debajyoti Das, Smitha Karunakaran, Siddharth Nanguneri, Deepti Bapat, Ajit Ray, Eisha Shaw, David A. Bennett, Deepak Nair, Vijayalakshmi Ravindranath
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Nicholas J. Audette, Sarah M. Bernhard, Ajit Ray, Luke T. Stewart, Alison L. Barth
Review
Neurosciences
Alison L. Barth, Ajit Ray
Article
Biochemistry & Molecular Biology
Reddy Peera Kommaddi, Deepika Singh Tomar, Smitha Karunakaran, Deepti Bapat, Siddharth Nanguneri, Ajit Ray, Bernard L. Schneider, Deepak Nair, Vijayalakshmi Ravindranath
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Clinical Neurology
Aditi Verma, Ajit Ray, Deepti Bapat, Latha Diwakar, Reddy Peera Kommaddi, Bernard L. Schneider, Etienne C. Hirsch, Vijayalakshmi Ravindranath
MOVEMENT DISORDERS
(2020)
Article
Biochemistry & Molecular Biology
Dika A. Kuljis, Kristina D. Micheva, Ajit Ray, Waja Wegner, Ryan Bowman, Daniel V. Madison, Katrin I. Willig, Alison L. Barth
Summary: The study revealed that some inhibitory synapses may lack gephyrin, which could play an important role in dynamically regulating cell activity under different physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ajit Ray, Joseph A. Christian, Matthew B. Mosso, Eunsol Park, Waja Wegner, Katrin I. Willig, Alison L. Barth
Summary: High-throughput anatomic data can generate new hypotheses about neural circuit changes. This study used fluorescence-based reagents to examine synapse changes in somatosensory cortex during whisker-dependent learning. The researchers found rapid morphologic changes in thalamocortical synapses at the early stages of training.
JOURNAL OF NEUROSCIENCE
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)