Article
Biochemistry & Molecular Biology
Evelin Csepanyi, Alexandra Gyongyosi, Istvan Lekli, Arpad Tosaki, Istvan Bak
Summary: This study suggests that beta-carotene may become pro-oxidant under severe oxidative conditions, potentially enhanced by the presence of iron. The use of an iron-chelator can reverse the pro-oxidant effects of beta-carotene and reduce cardiac injury caused by ischemia/reperfusion.
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Geetanjali Singh, Vibhav Varshney, Ahsas Goyal, Nemat Ali, Muzaffar Iqbal, Ishnoor Kaur, Celia Vargas-De-La-Cruz, Tapan Behl
Summary: The study found that chrysin enhances the therapeutic effect of ischemic preconditioning (IPC) in diabetic rat hearts via the PI3K-Akt-eNOS signaling pathway, reducing ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Bora Kim, Hyejin Sim, Jong Dai Kim, Ji Hyeon Ahn, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Soo Young Choi
Summary: The study demonstrates that ischemic brain damage or death induced under hyperthermic conditions is more severe and widespread than under normothermic conditions, with differing effects of HO-1 expression in neurons and astrocytes based on brain subregions and temperature conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medical Laboratory Technology
Cai Lei, Ying Tan, Dan Ni, Jinfu Peng, Guanghui Yi
Summary: Double stranded DNA (dsDNA) acts as a damage-associated molecular pattern (DAMP) that triggers the body's innate immune response. The cGAS-STING pathway is involved in cell death and is closely associated with the stimulation of self-DNA and autoimmune responses. This study provides an overview of the pathway's role in ischemia or ischemia/reperfusion studies in various organs.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Surgery
Glauber C. de Oliveira, Walmar K. de Oliveira, Winston B. Yoshida, Marcone L. Sobreira
Summary: This study assessed the beneficial effects of ischemic preconditioning (IPC) in liver resection and evaluated its applicability in clinical practice. The results showed that IPC can reduce intraoperative blood loss and the risk of postoperative ascites, but it has no significant impact on postoperative liver function and length of hospital stay. Therefore, although IPC is feasible in clinical practice, more evidence is needed to support its routine use.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Mahshid Deldar Abad Paskeh, Ava Asadi, Sepideh Mirzaei, Mehrdad Hashemi, Maliheh Entezari, Rasoul Raesi, Kiavash Hushmandi, Ali Zarrabi, Yavuz Nuri Ertas, Amir Reza Aref, Saeed Samarghandian, Russel J. Reiter, Jun Ren
Summary: Ischemia is a pathological process that temporarily interrupts blood supply to an organ, leading to cellular and tissue damage. Ischemia/reperfusion (I/R) injury exacerbates oxidative stress-mediated damage. This article discusses the role of AMP-activated protein kinase (AMPK) in I/R and its signaling pathways and therapeutic applications.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Yan Huang, Jianyang Liu, Jialin He, Zhiping Hu, Fengbo Tan, Xuelin Zhu, Fulai Yuan, Zheng Jiang
Summary: This study revealed that ferroptosis occurs in neuronal cells under cerebral I/R conditions, and UBIAD1 plays a neuroprotective role by restoring mitochondrial and Golgi apparatus dysfunction, enhancing antioxidative capacities, and regulating ferroptotic neuronal death.
CELL AND BIOSCIENCE
(2022)
Article
Urology & Nephrology
Wenjuan Yang, Tao Peng, Chunli Shi, Fang Cui, Menghua Chen, Ting Zhang
Summary: Delayed ischemic preconditioning (DIPC) has a protective effect on renal ischemia-reperfusion injury (IRI) by regulating the differentiation of dendritic cells (DCs) into immature DCs (imDCs), which in turn affects the differentiation and distribution of regulatory T cells (Treg).
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bingtian Xu, Jiangping Xu, Ningbo Cai, Mengfan Li, Lu Liu, Yunyun Qin, Xing Li, Haitao Wang
Summary: The PDE4 inhibitor Roflumilast has the potential to protect neurons from ischemic stroke-induced injury by activating the GSK3 beta/Nrf-2 signaling pathway and suppressing the IRE1 alpha/TRAF2/JNK pathway, reducing oxidative stress and apoptosis-related protein phosphorylation levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Woosuk Kim, Hyo Young Jung, Dae Young Yoo, Hyun Jung Kwon, Kyu Ri Hahn, Dae Won Kim, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang
Summary: The study demonstrates that GPE-R has neuroprotective effects against ischemic damage and inflammation in the hippocampus, reducing locomotor hyperactivity and increasing neuronal survival. It also shows a decrease in pro-inflammatory cytokines and activated microglia after ischemia/reperfusion, indicating GPE-R as a potential agent for protecting neurons from ischemic damage.
Article
Cell Biology
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, In Koo Hwang, Goang-Min Choi, In Bok Chang, Dae Won Kim, Seung Myung Moon
Summary: Tat-SH3GL2 protects neurons from oxidative and ischemic damage by reducing lipid peroxidation and inflammation, and improving synaptic plasticity after ischemia.
Article
Plant Sciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Soon-Sung Lim, Beom-Goo Kang, Yong-Bok Jo, Dong-Sool Yu, Soo Young Choi, In Koo Hwang, Dae Won Kim
Summary: The study showed that Cissus verticillata leaf extract has significant benefits in alleviating obesity and memory deficits induced by a high-fat diet in mice, with the improvement associated with increased levels of BDNF in the hippocampus.
Article
Plant Sciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Soon-Sung Lim, Beom-Goo Kang, Yong-Bok Jo, Dong-Sool Yu, Soo Young Choi, In Koo Hwang, Dae Won Kim
Summary: The Cissus verticillata leaf extracts (CVE) exhibited dose-dependent toxicity in HT22 cells, but could ameliorate oxidative and ischemic neuronal damage at suitable concentrations. In animal studies, administration of CVE decreased ischemia-induced motor activity, neuronal death, and inflammatory responses, indicating its potential as a functional food to prevent neuronal damage induced by ischemia.
Article
Neurosciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: Purpurin has significant therapeutic effects on oxidative stress in HT22 cells and ischemic damage in gerbil hippocampus by improving cell survival, reducing DNA fragmentation and reactive oxygen species, inhibiting apoptosis-related protein levels, and decreasing inflammatory responses.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Phosphoglycerate mutase 5 (PGAM5), a glycolytic enzyme, has been found to play a significant role in oxidative stress and ischemic damage. In this study, the authors investigated the effects of PGAM5 on HT22 hippocampal cells and gerbil hippocampus, demonstrating its neuroprotective effects and its ability to alleviate oxidative stress and ischemia-induced neuronal death.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, the researchers synthesized the Tat-CHIP fusion protein and successfully delivered it into brain cells. The results showed that Tat-CHIP has antioxidant and neuroprotective effects, making it a potential therapeutic agent against ischemic damage.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, In Koo Hwang, Dae Won Kim, Yeo Sung Yoon
Summary: This study investigated the neuroprotective effects of SOD1 against cuprizone-induced demyelination and adult hippocampal neurogenesis in C57BL/6 mice. It was found that the fusion protein PEP-1-SOD1 could alleviate the damage caused by cuprizone in terms of demyelination and neurogenesis in the hippocampus.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hyun Jung Kwon, Kyu Ri Hahn, Sung Min Nam, Yeo Sung Yoon, Seung Myung Moon, In Koo Hwang, Dae Won Kim
Summary: Purpurin has potent anti-oxidant and anti-inflammatory effects in brain damage. This study shows that purpurin can ameliorate the aging phenotypes induced by D-galactose and improve memory impairment in mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Veterinary Sciences
Dae Young Yoo, Woosuk Kim, Hyo Young Jung, In Koo Hwang
Summary: The expression of somatostatin (SST) in the hippocampus of rats increases during postnatal development but decreases after P21. This study suggests that SST is closely associated with the differentiation of neuroblasts in the hippocampus during postnatal development.
VETERINARY SCIENCES
(2023)
Article
Cell Biology
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, a fusion protein PEP-1-PGK1 was synthesized that can cross the blood-brain barrier, and it was found that low concentrations of PEP-1-PGK1 can prevent neuronal stress and ischemia-related damage.
Article
Medicine, Research & Experimental
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Min Soo Kang, Hyun Jung Kwon, Jung Hoon Choi, Yeo Sung Yoon, Dae Won Kim, Dae Young Yoo, Moo-Ho Won, In Koo Hwang
Summary: The study investigated the time-dependent changes in the expression of vacuolar H+-ATPase V1B2 in the hippocampus after transient forebrain ischemia, revealing a transient increase in ATP6V1B2 expression following ischemia. This increase may be a compensatory mechanism for ischemia-related dysfunction of ATP6V1B2 in the hippocampus.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Sung Min Nam, Sun Shin Yi, Hyun Jung Kwon, Min Soo Kang, Jung Hoon Choi, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang
Summary: The study revealed that EP2 levels decrease with age in the hippocampus and are closely linked to the differentiation of neuroblasts in the dentate gyrus.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Cell Biology
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB pathway, while also antagonizing the effects of TrkB receptor antagonist.
NEURAL REGENERATION RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
