Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway

Roflupram exerts neuroprotection via activation of CREB/PGC‐1α signalling in experimental models of Parkinson's disease

(2020) Jiahong Zhong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Beyond repression of Nrf2: An update on Keap1

(2020) Aleksandra Kopacz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

(2020) Aishika Datta et al.   Translational Stroke Research

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   BRITISH JOURNAL OF PHARMACOLOGY

Silencing RNF13 Alleviates Mice Models with Parkinson’s Disease via Regulating Endoplasmic Reticulum Stress–Mediated IRE1α-TRAF2-ASK1-JNK Pathway

(2020) Meng Ji et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Acute Ischemic Stroke

(2020) William J. Powers   NEW ENGLAND JOURNAL OF MEDICINE

SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response

(2020) Huimin Liu et al.   Cell Death & Disease

Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway

(2020) Qianwen Zheng et al.   BIOCHEMICAL PHARMACOLOGY

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease

(2020) Yi Sun et al.   BIOORGANIC CHEMISTRY

Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders

(2020) Abid Bhat et al.   PHARMACOLOGICAL RESEARCH

A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation

(2020) Sha Liao et al.   Redox Biology

FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway

(2019) Bingtian Xu et al.   BIOCHEMICAL PHARMACOLOGY

The Protein Disulfide Isomerase Family: from proteostasis to pathogenesis

(2019) Motonori Matsusaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

(2019) Jong S. Kim   Journal of Stroke

Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells

(2019) Jiao Xiao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Mechanistic Rationale for PDE-4 Inhibitors to Treat Residual Cognitive Deficits in Acquired Brain Injury

(2019) Rudy Schreiber et al.   Current Neuropharmacology

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease

(2019) Shijia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relevance of Nrf2 and heme oxygenase-1 in articular diseases

(2019) Maria José Alcaraz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway

(2019) Bingtian Xu et al.   Redox Biology

Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation

(2018) Berta Anuncibay-Soto et al.   BIOCHEMICAL PHARMACOLOGY

The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion

(2018) Jiajia Chen et al.   BRAIN RESEARCH BULLETIN

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa

(2018) Souvik Dey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

(2018) Amanda Santiago et al.   NEUROPHARMACOLOGY

Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP + -induced decline of mitochondrial membrane potential and oxidative stress

(2018) Jiahong Zhong et al.   Redox Biology

WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis

(2018) Elad Prinz et al.   MOLECULAR BIOLOGY OF THE CELL

The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

(2018) Kristine Faye R. Pobre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast

(2017) Edward W. Vogel et al.   EXPERIMENTAL NEUROLOGY

Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO

(2017) Devin W. McBride et al.   Translational Stroke Research

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

(2017) Ambika Krishnankutty et al.   Scientific Reports

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system

(2015) S. Sugin Lal Jabaris et al.   BRAIN RESEARCH

Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway

(2014) Rashika Joshi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY