Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

The two major glucokinase isoforms show conserved functionality in β-cells despite different subcellular distribution

(2018) Brian Lu et al.   BIOLOGICAL CHEMISTRY

Relationship between serum betatrophin levels and the first-phase of glucose-stimulated insulin secretion

(2018) Dan Liu et al.   Obesity Research & Clinical Practice

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

(2016) Rachel E. Stamateris et al.   DIABETES

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

(2016) Aaron R. Cox et al.   PLoS One

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

(2015) M M El Khatib et al.   GENE THERAPY

Beyond Bar and Line Graphs: Time for a New Data Presentation Paradigm

(2015) Tracey L. Weissgerber et al.   PLOS BIOLOGY

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

(2015) Claire A. Schreiber et al.   PLoS Pathogens

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Beta cell regeneration after single-round immunological destruction in a mouse model

(2014) Jason M. Tonne et al.   DIABETOLOGIA

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure

(2014) Yunhua L. Muller et al.   DIABETOLOGIA

Lessons from glucokinase activators: the problem of declining efficacy

(2014) Loranne Agius   EXPERT OPINION ON THERAPEUTIC PATENTS

Murine Leukemia Virus Uses NXF1 for Nuclear Export of Spliced and Unspliced Viral Transcripts

(2014) T. Sakuma et al.   JOURNAL OF VIROLOGY

Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

(2014) Jalal Taneera et al.   Journal of Diabetes Research

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced  -cell damage and pancreatic Glp-1 gene therapy

(2013) J. M. Tonne et al.   Disease Models & Mechanisms

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

(2013) Jasper Akerboom et al.   Frontiers in Molecular Neuroscience

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

(2012) Jalal Taneera et al.   Cell Metabolism

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats

(2011) Alessandro Cataliotti et al.   CIRCULATION

Secretion of Glycosylated Pro-B-Type Natriuretic Peptide from Normal Cardiomyocytes

(2011) J. M. Tonne et al.   CLINICAL CHEMISTRY

Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes

(2011) G. E. Meininger et al.   DIABETES CARE

Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic β-Cells Through Glycolysis and Calcium Channels

(2011) Seth J. Salpeter et al.   ENDOCRINOLOGY

Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months

(2011) Jonatan Ahrén et al.   Islets

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass

(2008) Akinobu Nakamura et al.   ENDOCRINOLOGY