Mek1 Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome

Cobimetinib

(2016) Jessie Signorelli et al.   ANNALS OF PHARMACOTHERAPY

Issue Information

(2016)   Clinical Respiratory Journal

Pathogenetics of the RASopathies

(2016) William E. Tidyman et al.   HUMAN MOLECULAR GENETICS

Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect

(2016) Rifdat Aoidi et al.   Science Signaling

Dabrafenib plus Trametinib: a Review in Advanced Melanoma with a BRAF V600 Mutation

(2016) Sohita Dhillon   Targeted Oncology

Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

(2016) Lei Xing et al.   eLife

Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect

(2016) Rifdat Aoidi et al.   Science Signaling

RASopathies: unraveling mechanisms with animal models

(2015) G. A. Jindal et al.   Disease Models & Mechanisms

Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways

(2015) Yi-Hsien Chen et al.   GENES & DEVELOPMENT

A phase II evaluation of selumetinib (AZD6244, ARRY-142886), a selective MEK-1/2 inhibitor in the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study

(2015) Robert L. Coleman et al.   GYNECOLOGIC ONCOLOGY

Adult mice expressing aBrafQ241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype

(2015) Mitsuji Moriya et al.   HUMAN MOLECULAR GENETICS

Recent advances in RASopathies

(2015) Yoko Aoki et al.   JOURNAL OF HUMAN GENETICS

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Recent developments in neurofibromatoses and RASopathies: Management, diagnosis and current and future therapeutic avenues

(2014) Katherine A. Rauen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Essential role of the ERK/MAPK pathway in blood-placental barrier formation

(2014) Valérie Nadeau et al.   DEVELOPMENT

Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation

(2014) Corina Anastasaki et al.   HUMAN MOLECULAR GENETICS

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome

(2014) Shin-ichi Inoue et al.   HUMAN MOLECULAR GENETICS

The Protein Tyrosine Phosphatase Shp2 Is Required for the Generation of Oligodendrocyte Progenitor Cells and Myelination in the Mouse Telencephalon

(2014) L. A. Ehrman et al.   JOURNAL OF NEUROSCIENCE

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

(2014) Yong-Seok Lee et al.   NATURE NEUROSCIENCE

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Analysis of the Genome of a Korean Isolate of the Pieris rapae Granulovirus Enabled by Its Separation from Total Host Genomic DNA by Pulse-Field Electrophoresis

(2014) Yong Hun Jo et al.   PLoS One

K-RasV14Irecapitulates Noonan syndrome in mice

(2014) Isabel Hernández-Porras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Phase II Trial of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with BRAFV600E/K-Mutated Melanoma

(2013) F. Catalanotti et al.   CLINICAL CANCER RESEARCH

Deletion ofMAP2K2/MEK2: a novel mechanism for a RASopathy?

(2013) M.J.M. Nowaczyk et al.   CLINICAL GENETICS

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

The intermediate-activity L597VBRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway

(2012) C. Andreadi et al.   GENES & DEVELOPMENT

Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes

(2012) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Targeted Proteomic Quantification on Quadrupole-Orbitrap Mass Spectrometer

(2012) Sebastien Gallien et al.   MOLECULAR & CELLULAR PROTEOMICS

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

MEK Is a Key Regulator of Gliogenesis in the Developing Brain

(2012) Xiaoyan Li et al.   NEURON

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

(2012) O. Boucherat et al.   Biology Open

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

(2011) Xue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner

(2011) Jacquelyn A. Brown et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

(2011) J. Urosevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

A Phase II Study of PD-0325901, an Oral MEK Inhibitor, in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer

(2010) E. B. Haura et al.   CLINICAL CANCER RESEARCH

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

(2010) Peng-Chieh Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation

(2009) V. Nadeau et al.   DEVELOPMENT

Costello syndrome H-Ras alleles regulate cortical development

(2009) Annie Paquin et al.   DEVELOPMENTAL BIOLOGY

Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype–phenotype correlations

(2009) Maria Lisa Dentici et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neurofibromin Is Required for Barrel Formation in the Mouse Somatosensory Cortex

(2008) M. E. Lush et al.   JOURNAL OF NEUROSCIENCE