Article
Oncology
Lihong Liu, Yongjie Shui, Qianqian Yu, Yinglu Guo, Lili Zhang, Xiaofeng Zhou, Risheng Yu, Jianying Lou, Shumei Wei, Qichun Wei
Summary: Patients with narrow resection margin had higher recurrence rate and worse survival compared to those with wide resection margin. Adjuvant local treatment, such as radiotherapy, may benefit these patients. Postoperative SBRT for cases with positive margin showed low recurrence rate and no marginal recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Chih-Hsien Cheng, Yin Lai, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chao Wang, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Wei-Chen Lee
Summary: The study found that patients with very narrow surgical margins and those with wider surgical margins had comparable tumor recurrence rates and survival rates after hepatic resection for HCC. Most recurrences were multiple intrahepatic and associated with portal hypertension and adverse tumor biology.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Theodoros Michelakos, Filippos Kontos, Yurie Sekigami, Motaz Qadan, Lei Cai, Onofrio Catalano, Vikram Deshpande, Madhukar S. Patel, Teppei Yamada, Nahel Elias, Leigh Anne Dageforde, Shoko Kimura, Tatsuo Kawai, Kenneth K. Tanabe, James F. Markmann, Heidi Yeh, Cristina R. Ferrone
Summary: This study found that in patients with solitary hepatocellular carcinoma, different hepatic resection margin widths did not have a significant impact on overall survival, recurrence-free survival, and liver-specific recurrence-free survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Jiang-Min Zhou, Chen-Yang Zhou, Xiao-Ping Chen, Zhi-Wei Zhang
Summary: In patients with tumors ranging from 2-5 cm, anatomic resection (AR) can effectively remove peritumoral microvascular invasion (MVI) by obtaining a wide surgical margin, reducing postoperative recurrence, and improving prognosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Daniel Hoffman, Amy Shui, Ryan Gill, Shareef Syed, Neil Mehta
Summary: AFP >= 1000 ng/mL, multinodularity, and vascular invasion were found to be independent risk factors for HCC recurrence. The researchers developed the RESTORE index to predict HCC recurrence risk, which can stratify the risk into different levels based on patient's scores.
Article
Oncology
Andriy Trailin, Lenka Cervenkova, Filip Ambrozkiewicz, Esraa Ali, Phanindra Kasi, Richard Palek, Petr Hosek, Vladislav Treska, Ondrej Daum, Zbynek Tonar, Vaclav Liska, Kari Hemminki
Summary: This study found that the distribution and numbers of T- and B-lymphocytes in different regions of the resected tumor have different prognostic significance for time to recurrence and disease-free survival in patients with hepatocellular carcinoma (HCC). The density of nucleated lymphocyte profiles in specific regions predicted longer time to recurrence and disease-free survival, highlighting the overall heterogeneity of the tumor invasive margin and the importance of B-cells in predicting outcomes.
Article
Multidisciplinary Sciences
Nanping Lin, Lei Wang, Qizhen Huang, Weiping Zhou, Xiaolong Liu, Jingfeng Liu
Summary: This study developed a nomogram model to predict the overall survival of hepatocellular carcinoma patients who underwent R0 resection. The model showed good calibration and discriminatory power, and it was found that p-TACE could significantly prolong the median overall survival in high-risk patients.
Article
Oncology
Qiao Ke, Zhiting Guo, Jian He, Zisen Lai, Fuli Xin, Yongyi Zeng, Lei Wang, Jingfeng Liu
Summary: The width of resection margin (RM) does not appear to have a significant impact on the prognosis of patients with solitary hepatocellular carcinoma (HCC) undergoing anatomical resection (AR). However, in certain selected patients, a wider RM may confer benefits.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Surgery
Tomoyuki Nishimura, Shiro Oka, Yuki Kamigaichi, Hirosato Tamari, Yasutsugu Shimohara, Yuki Okamoto, Katsuaki Inagaki, Hidenori Tanaka, Ken Yamashita, Ryo Yuge, Yuji Urabe, Koji Arihiro, Fumio Shimamoto, Shinji Tanaka
Summary: Complete en bloc resection with sufficient submucosal layer from the invasive front reduces the risk of metastatic recurrence after additional surgery for T1 colorectal carcinoma (CRC).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Oncology
Liuhua Long, Bo Chen, Hongzhi Wang, Yuting Zhao, Fan Wu, Liming Wang, Weiqi Rong, Jianxiong Wu, Yexiong Li, Weihu Wang
Summary: This study evaluated the effects of postoperative radiotherapy (PORT) on prognosis and recurrence in patients with hepatocellular carcinoma (HCC) who underwent narrow-margin hepatectomy (NH). The results showed that the PORT group had significantly higher 5-year overall survival and disease-free survival rates compared to the non-PORT group, and the tumor recurrence rate was lower in the PORT group. Therefore, postoperative radiotherapy may have significant benefits in the treatment of HCC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Yao Huang, Hengkai Chen, Yongyi Zeng, Zhiqiang Liu, Handong Ma, Jingfeng Liu
Summary: A machine learning prognostic model was developed to identify high-risk patients after surgical resection, with variable importance reviewed in different time intervals. Tumor characteristics contribute more to HCC relapse in 0 to 1 year, while HBV infection and smoking largely affect patients' outcome in 3 to 5 years.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sungho Kim, Chang Jin Yoon, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Moonhwan Kim, Boram Lee, Soyeon Ahn
Summary: LLR and RFA were compared in the treatment of single, small HCCs located in the anterolateral liver segments. LLR showed similar complication and overall survival rates but better disease-free survival compared to RFA. LLR may be recommended for patients with higher alpha-fetoprotein levels.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Surgery
Mizelle D'Silva, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Moonhwan Kim
Summary: Laparoscopic left lateral sectionectomy (LLLS) is a standard approach for patients, and achieving textbook outcomes (TOs) is crucial. This study identified factors associated with achieving TOs after LLLS. The main determinant for achieving a TO was prolonged hospital stay, while other factors such as year of surgery, ASA score, BMI score, inflow clamping time, and operation time were also significant. Our outcomes were similar to benchmark values for most criteria, except for the transfusion rate, which was worse in our patients. However, we achieved better outcomes in terms of conversion rate, transfusion requirement, inflow clamping, complication rate, reoperation rate, and positive margin.
UPDATES IN SURGERY
(2022)
Article
Gastroenterology & Hepatology
Mizelle D'Silva, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Moonhwan Kim, Yeongsoo Jo
Summary: This study evaluated the factors affecting the achievement of textbook outcomes (TO) for laparoscopic liver resection (LLR) and its impact on survival. The study found that Model for End-stage Liver Disease (MELD) score, thrombocytopenia, and hypoalbuminemia were independent risk factors influencing the achievement of TO. The TO group had significantly higher overall and recurrence-free survival rates compared to the non-TO group.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Surgery
Boram Lee, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Moonhwan Kim, Yeongsoo Jo
Summary: This study proposes a new simplified scoring system based on the Geriatric Nutritional Risk Index (GNRI) to predict major complications after laparoscopic liver resection (LLR) in elderly patients with hepatocellular carcinoma (HCC). The study found that the GNRI, Child-Turcotte-Pugh score, major liver resection, and intraoperative transfusion were independent predictors of major postoperative complications. The scoring system showed good discrimination in predicting major complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Woohyung Lee, Dae Wook Hwang, Ho-Seong Han, In Woong Han, Jin Seok Heo, Michiaki Unno, Masaharu Ishida, Hiroshi Tajima, Nobuyuki Nishizawa, Kohei Nakata, Yasuji Seyama, Yoshiya Isikawa, Ho Kyoung Hwang, Jin-Young Jang, Taeho Hong, Joon Seong Park, Hee Joon Kim, Chi-Young Jeong, Ippei Matsumoto, Hiroki Yamaue, Manabu Kawai, Masayuki Ohtsuka, Shugo Mizuno, Mitsuhiro Asakuma, Yuji Soejima, Teijiro Hirashita, Masayuki Sho, Yutaka Takeda, Jeong-Ik Park, Yong Hoon Kim, Hwa Jung Kim, Masakazu Yamamoto, Itaru Endo, Masafumi Nakamura, Yoo-Seok Yoon
Summary: The study aimed to evaluate the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. By comparing the data of postoperative infectious complications in different groups, the study found that spleen preservation could lower the risk of infectious complications, but the risk may vary according to the surgeon's experience.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Min Kyu Sung, Hosub Park, Guisuk Park, Seo Young Park, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang, Seung Mo Hong
Summary: This study investigated the prognostic implications of extranodal extension (ENE) in patients with surgically resected pancreatic cancer. The results showed that patients with ENE had lower disease-free survival rates, especially those with nodal metastasis. Therefore, ENE should be considered a prognostic factor in the staging system of pancreatic cancer.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Min Kyu Sung, Ki Byung Song, Sarang Hong, Yejong Park, Bong Jun Kwak, Eunsung Jun, Woohyung Lee, Jae Hoon Lee, Dae Wook Hwang, Song Cheol Kim
Summary: This study evaluated the feasibility and safety of laparoscopic vein resection in pancreatic head cancer with PV/SMV invasion, and compared the survival rate between laparoscopic surgery and open surgery. The results showed no significant differences in complications, tumor recurrence, pathological outcomes, and disease-free survival between the two groups. The surgical method was not an independent prognostic factor for disease-free survival.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Gianluca Cassese, Ho-Seong Han, Eunhye Lee, Boram Lee, Hae Won Lee, Jai Young Cho, Roberto Montalti, Roberto Ivan Troisi
Summary: This study retrospectively analyzed the short- and long-term outcomes of laparoscopic liver resection (LLR) versus open liver resection (OLR) for patients with multiple hepatocellular carcinomas (HCC). The study found that LLR can be safe and effective in selected cases of multiple HCC, resulting in a shorter hospital stay without affecting perioperative and long-term oncological outcomes.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Yeshong Park, Ho-Seong Han, Yoo-Seok Yoon, Chang Jin Yoon, Hae Won Lee, Boram Lee, Meeyoung Kang, Jinju Kim, Jai Young Cho
Summary: This study investigated the role of salvage hepatectomy (SH) as a rescue therapy for recurrent hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). The study found that SH showed safety and effectiveness equivalent to primary resection in terms of short-term and long-term outcomes. However, due to the higher grade and more aggressive behavior of recurrent tumors, more extensive resections with wide surgical margins are necessary to prevent recurrence.
Article
Medicine, General & Internal
Yeshong Park, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Boram Lee, MeeYoung Kang, Jinju Kim
Summary: This study compares the outcomes of open and laparoscopic approaches in salvage hepatectomy for recurrent hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). The results showed that laparoscopic surgery has comparable oncologic outcomes to open surgery with faster postoperative recovery rates.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
MeeYoung Kang, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Boram Lee, Yeshong Park, Jinju Kim, Chang Jin Yoon
Summary: A retrospective study compared the outcomes of laparoscopic liver resection (LLR) and radiofrequency ablation (RFA) for single small HCC in the left lateral segment. It showed that LLR had better disease-free survival (DFS) and similar overall survival (OS) compared to RFA, with shorter hospital stay but higher complication rate in the RFA group.
MEDICINA-LITHUANIA
(2023)
Article
Surgery
Sujin Gang, YoungRok Choi, Boram Lee, Kyung Chul Yoon, Su Young Hong, Sanggyun Suh, Eui Soo Han, Suk Kyun Hong, Hae Won Lee, Jai Young Cho, Nam-joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: Liver grafts from donors with active or chronic HBV infection can be safely used for liver transplantations, and long-term outcomes are similar to those from non-hepatitis virus-infected grafts.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)
Article
Medicine, General & Internal
Yeongsoo Jo, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Eunhye Lee, Yeshong Park, MeeYoung Kang, Junghyun Lee
Summary: A novel difficulty scoring system (nDSS) was developed and validated in this study for predicting the surgical difficulty and outcomes of laparoscopic liver resection (LLR) for hepatolithiasis. The nDSS score was found to be significantly associated with the rates of red blood cell transfusion, postoperative hospital stay, and major complications. Patients in the high nDSS group had longer operation time, greater estimated blood loss, higher rates of red blood cell transfusion, longer postoperative hospital stay, and higher major complication rate compared to those in the low nDSS group.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Hyo Jun Kim, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Yeongsoo Jo, Meeyouong Kang, Yeshong Park, Eunhye Lee
Summary: This study aimed to evaluate the feasibility and safety of laparoscopic liver resection (LLR) for centrally located hepatocellular carcinoma (cHCC) and compare it with open liver resection (OLR). The results showed that LLR had significantly lower intraoperative blood loss, transfusion rate, and hospital stay compared to OLR. There were also improvements in operation time and intraoperative blood loss with the advancement of laparoscopic techniques.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Yujin Kwon, Boram Lee, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Munwhan Kim, Youngsoo Jo
Summary: This study analyzed the effectiveness of laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) located in the posterosuperior (PS) segment before and after the introduction of advanced techniques. The results showed that the use of advanced techniques led to shorter operation time and hospital stay, while the resection margin was smaller. There were no significant differences between the two groups in terms of complications, clinical-pathological grading, and 5-year overall survival rates.
MEDICINA-LITHUANIA
(2022)
