Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation

Fish, a Mediterranean source of n-3 PUFA: benefits do not justify limiting consumption

(2015) Angel Gil et al.   BRITISH JOURNAL OF NUTRITION

Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients

(2015) Romain Colas et al.   THROMBOSIS AND HAEMOSTASIS

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

(2015) Sharad S. Singhal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes

(2013) Guy Cohen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress

(2012) Nicolas J. Pillon et al.   ENDOCRINOLOGY

Dietary oxidizedn-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells

(2012) Manar Awada et al.   JOURNAL OF LIPID RESEARCH

Quantitative structure–activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells

(2010) Nicolas J. Pillon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men

(2009) Catherine Calzada et al.   ATHEROSCLEROSIS

Increasing intakes of the long-chain ω-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men

(2009) Nicolas Guillot et al.   FASEB JOURNAL

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex

(2009) Eric K. Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapid and easy method for monitoring oxidative stress markers in body fluids of patients with asbestos or silica-induced lung diseases

(2009) Kamila Syslová et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

(2009) Nava Bashan et al.   PHYSIOLOGICAL REVIEWS

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

(2008) D. Demozay et al.   DIABETES

Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation

(2008) Eric K. Long et al.   JOURNAL OF NEUROCHEMISTRY

Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk - A preliminary study

(2008) Marie-Caroline Michalski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY