Article
Medicine, General & Internal
Fonthip Laohavisudhi, Titikorn Chunchai, Natnicha Ketchaikosol, Wacharaporn Thosaporn, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This study found that CD44s, CD44v6, CXCR2, and IL-113 were expressed at higher levels in salivary gland tumors, with IL-113 potentially playing a crucial role in the aggressiveness of these tumors.
Article
Cell Biology
Shun He, Yuanyuan Lu, Yuetong Guo, Shijin Li, Xiao Lu, Shuai Shao, Handan Zhou, Ruiqi Wang, Jiguang Wang, Pingjin Gao, Xiaodong Li
Summary: The study revealed that KLF15 in cardiac fibroblasts negatively regulates the CXCL1/CXCR2 axis-mediated inflammatory response and subsequent cardiac remodeling in hypertension.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jan Korbecki, Katarzyna Barczak, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: CXCL1 is an important chemokine involved in the development of inflammatory diseases. Its expression is elevated in inflammatory reactions and it plays important roles in physiology. This paper presents the mechanisms of CXCL1 expression regulation with a focus on cancer, including transcription regulation, mRNA stability, and activity regulation in the extracellular space. The role of CXCL1 in cancer and potential therapeutic approaches are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Rui Yan, Jianjian Li, Zeru Xiao, Xiaona Fan, Heshu Liu, Ying Xu, Ruya Sun, Jian Liu, Jiannan Yao, Guangyu An, Yan Shi, Yang Ge
Summary: This study found that the gastrointestinal cancer stem cell marker DCLK1 is strongly associated with poor outcomes in colorectal cancer. In vivo experiments confirmed that DCLK1 promotes tumor growth and inhibits the host's antitumor response by recruiting T-cell-suppressive MDSCs. These findings provide a precise therapeutic target for related clinical interventions.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Jan Korbecki, Mateusz Bosiacki, Katarzyna Barczak, Ryta Lagocka, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This review provides a detailed analysis of the role of CXCL1 chemokine in gastrointestinal cancers, including its impact on cancer cell processes and immune system cells. It also discusses the clinical association of CXCL1 with tumor characteristics and patient prognosis. The potential of CXCL1 as a therapeutic target in anticancer therapy is explored.
Article
Oncology
Chong Zhong Liu, Xing Bao Liu, Jun Sun, Chao Qun Yu, Jing Chun Yao, Zhong Liu, Jing Cheng Hao
Summary: This study analyzed the percentage of CD14(+)CXCR2(+) monocyte subsets in hepatocellular carcinoma (HCC) patients and investigated the mechanisms that regulate CXCR2 surface expression on monocytes. The results showed that the proportion of CD14(+)CXCR2(+) monocyte subset was decreased in HCC patients compared to healthy controls. The overexpression of IL-8 was found to be negatively correlated with the proportion of CXCR2(+) monocyte subset and decreased the antitumor activity of monocytes towards HCC cells.
Article
Oncology
Masataka Hayashi, Naoki Ikenaga, Kohei Nakata, Haizhen Luo, PingShan Zhong, Satomi Date, Koki Oyama, Nobuhiro Higashijima, Akihiro Kubo, Chika Iwamoto, Nobuhiro Torata, Toshiya Abe, Yutaka Yamada, Kenoki Ohuchida, Yoshinao Oda, Masafumi Nakamura
Summary: Intratumor bacteria, such as Fusobacterium nucleatum, can influence the tumor immune microenvironment and affect the prognosis of pancreatic cancer. In this study, F. nucleatum was detected in 15.5% of pancreatic cancer patients and was associated with larger tumor size. F. nucleatum promoted cancer progression by inducing CXCL1 secretion from cancer cells and suppressing tumor-infiltrating CD8(+) T cells. Blocking the CXCL1-CXCR2 axis may be a potential therapeutic strategy for patients with F. nucleatum-positive pancreatic cancer.
Article
Cell Biology
Huiyong Zhao, Sheng Wei, Dachen Zhou, Yongfan Liu, Zicheng Guo, Chuibao Fang, Xiaoxi Pang, Fei Li, Hui Hou, Xiao Cui
Summary: Inflammation is a core mechanism for oncogenesis, and chemokines play important roles in chronic inflammation and the tumour inflammatory response. This study investigates the protumor effects of CXCL1 in hepatocellular carcinoma (HCC), a disease derived from chronic liver inflammation. CXCL1 enhances tumorigenesis through direct effects on tumour cells and indirectly by promoting the recruitment of macrophages. Blocking CXCL1-CXCR2 inhibits tumour progression and reduces macrophage recruitment in the tumour microenvironment (TME), showing therapeutic potential for HCC patients with high CXCL1 expression.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Geun-Young Park, Harsh B. Pathak, Andrew K. Godwin, Youngjoo Kwon
Summary: The study suggests that CXCL1 derived from ovarian fibroblasts plays a key role in promoting ovarian cancer cell growth, potentially through p38 activation. Phosphorylated p38 may serve as a biomarker for predicting the interaction between CXCL1 and CXCR2 in vivo.
Article
Biology
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. K. Singh
Summary: Vascular adhesion molecules, specifically VCAM-1, have been found to play a crucial role in retinal neovascularization and can be regulated by IL-33. The study also highlights the regulatory role of VCAM-1-JunB-IL-8 signaling in retinal endothelial cell sprouting and angiogenesis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Samara Singh, Siddharth Mehra, Vanessa T. Garrido, Xinyu Guo, Luis A. Nivelo, Despina S. Kolonias, Shannon J. Saigh, Eric Wieder, Christine I. Rafie, Austin R. Dosch, Zhiqun Zhou, Oliver Umland, Haleh Amirian, Ifeanyichukwu C. Ogobuiro, Jian Zhang, Yuguang Ban, Carina Shiau, Nagaraj S. Nagathihalli, Elizabeth A. Montgomery, William L. Hwang, Roberta Brambilla, Krishna Komanduri, Alejandro V. Villarino, Eneda Toska, Ben Z. Stanger, Dmitry I. Gabrilovich, Nipun B. Merchant, Jashodeep Datta
Summary: We have found that the KRAS-TP53 genomic coalteration in PDAC patients is associated with immune-excluded microenvironments, chemoresistance, and poor survival. By studying the cell-autonomous Cxcl1 in PDAC, we have discovered its role in spatial T-cell restriction via interactions with neutrophilic myeloid-derived suppressor cells. Our findings reveal the cross-talk between cancer cells and neutrophils, and the involvement of TNF signaling in promoting immunosuppression and stromal inflammation in pancreatic tumor microenvironments.
Article
Medicine, Research & Experimental
Hong-xia Chang, Yue-feng Zhao
Summary: Emerging evidence suggests that protocatechuic acid (PCA) has antioxidant and anti-inflammatory effects, and can alleviate neuropathic pain in rats. The mechanism of action may be through inhibiting the JNK/CXCL1/CXCR2 signaling pathway and improving oxidative stress. These findings provide a novel perspective for the treatment of neuropathic pain caused by chronic constriction injury (CCI).
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Oncology
Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolanos, Inmaculada Rodriguez, Inaki Etxeberria, Assunta Cirella, Josune Egea, Saray Garasa, Itziar Migueliz, Inaki Eguren-Santamaria, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Beatrice Malacrida, David Propper, Carlos E. de Andrea, Pedro Berraondo, Frances R. Balkwill, Alvaro Teijeira, Ignacio Melero
Summary: In the tumor microenvironment, IL-8 correlates with poor response to checkpoint inhibitors and attracts immunosuppressive myeloid cells. TNF alpha and IL-1 beta are major inducers of IL-8 expression on malignant cells, which can be interfered with by clinically available neutralizing agents.
Article
Medicine, General & Internal
Weronika Pawlik, Jakub Pawlik, Mateusz Kozlowski, Karolina Luczkowska, Sebastian Kwiatkowski, Ewa Kwiatkowska, Boguslaw Machalinski, Aneta Cymbaluk-Ploska
Summary: This study found that serum levels of IL-8 and TNF-alpha were significantly higher in ovarian cancer patients compared to patients with benign ovarian cysts, and they can be used as new useful markers for predicting ovarian cancer. IL-8 and TNF-alpha have a sensitivity and specificity of 70% and 96%, and 85.7% and 79.3% respectively, indicating their utility in predicting the malignant nature of ovarian lesions.
Article
Biochemistry & Molecular Biology
Zhihao Wang, Biao Li, Haiyan Jiang, Yuchen Ma, Yanni Bao, Xiangyu Zhu, Hongguang Xia, Yong Jin
Summary: Alcoholic fatty liver disease (AFLD) is liver damage caused by chronic heavy drinking, with IL-8 potentially playing a role in its pathogenesis. Studies have shown that hIL-8 exacerbates alcohol-induced fatty liver disease in mice through the Akt/HIF-1 alpha pathway, highlighting a potential target for clinical treatment.
Article
Dentistry, Oral Surgery & Medicine
Mohammed Nadeem Bijle, Mohamed Mahmoud Abdalla, Chun Hung Chu, Cynthia Kar Yung Yiu
Summary: This study demonstrated the potential of synbiotic-fluoride therapy in promoting enamel remineralization without cytotoxic or genotoxic effects. The findings suggest that synbiotic-fluoride therapy could be a promising treatment for preventing caries in individuals at high risk.
JOURNAL OF DENTISTRY
(2023)
Article
Environmental Sciences
Katherine Chiu-Man Leung, Chun-Hung Chu
Summary: There is a global increase in the older population, resulting in poorer dental conditions due to worsened physical conditions and cumulative damage from past dental diseases. Many older adults suffer from dental caries and periodontal disease without regular dental care. Oral conditions and systemic problems are interrelated, with chronic medical issues and polypharmacy being common among older adults. Preventive measures and replacement of missing teeth are crucial, as well as addressing the higher risk of oral cancer in older adults. Dentists should equip themselves with knowledge and skills in geriatric dentistry to provide necessary care for the elderly.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mohammed Zahedul Islam Nizami, Vicky Wenqing Xue, Amy Wai Yee Wong, Ollie Yiru Yu, Conson Yeung, Chun Hung Chu
Summary: Challenge-based learning (CBL) is a collaborative and interdisciplinary learning approach that enables individuals to address real-world challenges together. It helps students develop a deeper understanding of the subjects they are studying, drawing on educational theories like problem-based learning and inquiry-based learning.
Article
Dentistry, Oral Surgery & Medicine
Iliana Gehui Yan, Faith Miaomiao Zheng, Iris Xiaoxue Yin, Ivy Guofang Sun, Edward Chin Man Lo, Chun Hung Chu
Summary: This study aims to determine the stability, alkalinity, and fluoride and silver ion concentrations of 5 commercially available 38% silver diamine fluoride (SDF) solutions. The study found that the alkalinity of the SDF solutions remained stable after 180 days, but the fluoride and silver concentrations decreased substantially after 60 days. It is recommended to use the SDF solution within 60 days after opening.
INTERNATIONAL DENTAL JOURNAL
(2023)
Article
Engineering, Chemical
Muhammad Zakir, Taina Laiho, Sari Granroth, Edwin Kukk, James K. H. Tsoi, C. H. Chu, Jukka P. Matinlinna
Summary: The objective of this study was to compare and contrast the effect of two novel dual surface modification methods on the surface morphology, changes in surface chemistry and to evaluate their enclosed mold micro-shear bond strength variation on artificial ageing. Different surface analysis techniques were used to study the effects of different surface modifications. The results indicated that the method of silicatization followed by etching may help in forming a durable chemical bond with a silane blend. Overall, this study is rated 8 out of 10 in terms of importance.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Review
Biochemistry & Molecular Biology
Olivia Lili Zhang, John Yun Niu, Ollie Yiru Yu, May Lei Mei, Nicholas Stephen Jakubovics, Chun Hung Chu
Summary: The objective of this study was to review the design methods used for peptides in caries management. Two researchers systematically reviewed in vitro studies and assessed bias risk. The review identified 3592 publications, of which 62 were selected. Template-based design method and conjugation method were the most commonly used in developing peptides for caries management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ivy Guofang Sun, Duangporn Duangthip, Edward Chin Man Lo, Chun Hung Chu
Summary: This 12-month randomized active-controlled clinical trial compares two post-treatment instructions for silver diamine fluoride (SDF) therapy in arresting dentine caries. Children with active dentine caries will be randomly assigned to two groups and receive topical application of a 38% SDF solution. The primary outcome is the proportion of caries lesions becoming arrested at the 12-month examination.
Review
Dentistry, Oral Surgery & Medicine
Ahmed Zaeneldin, Chun-Hung Chu, Ollie Yiru Yu
Summary: This review summarizes the use of silver-containing solutions for deep cavity disinfection and their effects on dental pulp. The search identified 14 publications that reported the use of silver fluoride, silver nitrate, silver diamine nitrate, silver diamine fluoride, and nano-silver fluoride for antimicrobial purposes in deep cavities. Different silver-containing solutions showed varying effects on pulp, with silver fluoride inducing inflammation and reparative dentine, silver nitrate causing blood clots and inflammation, and silver diamine fluoride leading to pulp necrosis. There was no available evidence on the pulpal response to silver diamine nitrate and nano-silver fluoride.
Review
Dentistry, Oral Surgery & Medicine
Olivia Lili Zhang, John Yun Niu, Iris Xiaoxue Yin, Ollie Yiru Yu, May Lei Mei, Chun Hung Chu
Summary: Researchers have developed novel bioactive materials for caries management, which are favored by clinicians who practice minimally invasive dentistry. Bioactive materials can form hydroxyapatite crystals on the tooth surface and include fluoride-based, calcium- and phosphate-based, graphene-based, metal and metal-oxide nanomaterials, and peptide-based materials.
Article
Biochemistry & Molecular Biology
Olivia Lili Zhang, John Yun Niu, Ollie Yiru Yu, Iris Xiaoxue Yin, May Lei Mei, Chun Hung Chu
Summary: This study investigated the antibiofilm and remineralising effects of peptide GAPI on artificial dentin caries. The results showed that the GAPI group had damaged S. mutans structures, lower colony-forming units, reduced caries depth, decreased mineral loss, and more crystallised hydroxyapatite compared to the control group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alice Kit Ying Chan, Yiu Cheung Tsang, Chloe Meng Jiang, Katherine Chiu Man Leung, Edward Chin Man Lo, Chun Hung Chu
Summary: This study aimed to evaluate the desensitizing effect of 38% silver diamine fluoride (SDF) solution on hypersensitive teeth in older adults. A double-blind randomized clinical trial was conducted, and participants received either 38% SDF or 5% potassium nitrate solution (control) on the root surface. The results showed that 38% SDF solution reduced hypersensitivity on the exposed root surface of older adults and was more effective than the control solution.
JOURNAL OF DENTISTRY
(2023)
Article
Infectious Diseases
Olivia Lili Zhang, John Yun Niu, Iris Xiaoxue Yin, Ollie Yiru Yu, May Lei Mei, Chun Hung Chu
Summary: A novel antimicrobial peptide, GAPI, has been developed by grafting gallic acid (GA) to polyphemusin I (PI). This laboratory study demonstrates that GAPI has antibacterial effects on common oral pathogens, causing abnormal changes in bacterial morphology.
Review
Dentistry, Oral Surgery & Medicine
Emma Kay Chan, Yuet Ying Wah, Walter Yu-Hang Lam, Chun-Hung Chu, Ollie Yiru Yu
Summary: The advance in digital diagnostic technologies has greatly improved the detection of dental caries. However, there is still a lack of comprehensive summary for all available technology. Digital diagnostic aids for caries detection can be categorized into radiation-based, light-based, ultrasound-based, and electric-based aids, each utilizing different energy sources.
Review
Dentistry, Oral Surgery & Medicine
Alice Kit Ying Chan, Yiu Cheung Tsang, Chloe Meng Jiang, Katherine Chiu Man Leung, Edward Chin Man Lo, Chun Hung Chu
Summary: Diet, nutrition, and oral health are closely connected. Older adults with malnutrition may face oral health problems, while poor oral conditions can affect nutritional intake. Malnutrition in older adults is associated with frailty, hospitalization, and mortality. Integrating oral health into the healthcare of older adults is essential for healthy aging.
Review
Chemistry, Multidisciplinary
Laura Jiaxuan Li, Chun-Hung Chu, Ollie Yiru Yu
Summary: Zeolites and zeolitic imidazolate frameworks (ZIFs) have great potential in dentistry, with applications in restorative dentistry, implantology, orthodontics, and more. They offer antibacterial, bone matrix scaffold, and other advantages.
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
