Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Ehab F. Girbash, Shaimaa M. Abdelwahab, Rehab M. Atef, Hala E. Sherif, Hussein M. Abdeldayem, Doaa S. Atta, Ahmed M. Radwan
Summary: This study aimed to evaluate the impact of maternal interleukin-17A and disease activity on pregnancy outcomes in Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients. The results showed that PsA and AS patients were more prone to preterm labor, oligohydramnios, caesarean delivery, and delivering infants small for gestational age. There was a significant difference in IL-17A levels between the study group and the control group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Georg Schett, Xenofon Baraliakos, Filip Van den Bosch, Atul Deodhar, Mikkel Ostergaard, Ayan Das Gupta, Shephard Mpofu, Todd Fox, Adam Winseck, Brian Porter, Abhijit Shete, Lianne S. Gensler
Summary: The study demonstrated that Secukinumab has significant efficacy in improving enthesitis in patients with ankylosing spondylitis, particularly in the axial and overall MASES scores, showing substantial improvements in patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Cell Biology
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Farhad Babaie, Jila Mahdavi, Misagh Rajabinejad, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
Summary: ER stress in macrophages from AS patients plays a role in the increased production of IL-23. The autophagy pathway is not involved in the modulation of IL-23 production by AS macrophages.
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Rheumatology
Neslihan Gokcen, Aylin Sariyildiz, Ilke Coskun Benlidayi
Summary: This study evaluated static foot posture in patients with ankylosing spondylitis (AS) and found that AS patients had significantly higher foot posture scores compared to healthy controls, with abnormal foot posture being more common in the patient group. The study also showed that enthesitis is related to deteriorated static foot posture in AS patients, with enthesitis of the Achilles tendon closely associated with supinated foot posture.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Dermatology
Alice B. Gottlieb, Atul Deodhar, Iain B. Mcinnes, Xenofon Baraliakos, Kristian Reich, Stefan Schreiber, Weibin Bao, Kwaku Marfo, Hanno B. Richards, Luminita Pricop, Abhijit Shete, Vivek Trivedi, Deborah Keefe, Charis C. Papavassilis, Piotr Jagiello, Philemon Papanastasiou, Philip J. Mease, Mark Lebwohl
Summary: This study reports the long-term safety of Secukinumab in a large dataset, including patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. The results show that Secukinumab has a favorable safety profile for up to 5 years of treatment in these indications, and no new safety signals were identified.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Immunology
Dennis McGonagle, Abdulla Watad, Kassem Sharif, Charlie Bridgewood
Summary: IL-23 plays a crucial role in spondyloarthritis, with implications in the genetic basis, disease progression and treatment efficacy. However, further studies are necessary to determine the specific effects and mechanisms of IL-23 in different disease sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Lin Wang, Xiaofang Ping, Wei Chen, Weibin Xing
Summary: The study confirmed the effectiveness of JAK inhibitors in improving the condition of both PsA and AS patients, as well as in alleviating psoriasis-related dermal lesions. Higher doses of tofacitinib yielded better treatment responses, though with increased safety concerns.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Rheumatology
Muenevver Serdaroglu Beyazal, Aliekber Tayfun, Gul Devrimsel, Murat Yildirim, Medeni Arpa
Summary: This study found that serum IL-17 and IL-23 levels were significantly increased in patients with ankylosing spondylitis (AS), and IL-17 levels were associated with disease activity.
AKTUELLE RHEUMATOLOGIE
(2023)
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.
Review
Genetics & Heredity
Davide Simone, Alessia Stingo, Francesco Ciccia
Summary: Th17 cells are considered as the main drivers of disease in Spondyloarthropathies, able to modulate gene expression and function in response to different immune environments. Research has shown that Th17 cells recognizing different microorganisms can acquire specific cytokine signatures, and their heterogeneity is associated with metabolic needs.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Charlie Bridgewood, Kassem Sharif, Jonathan Sherlock, Abdulla Watad, Dennis McGonagle
IMMUNOLOGICAL REVIEWS
(2020)
Article
Rheumatology
Abdulla Watad, Hannah Rowe, Tobias Russell, Qiao Zhou, Lisa K. Anderson, Almas Khan, Robert Dunsmuir, Peter Loughenbury, Vishal Borse, Abhay Rao, Peter A. Millner, Nicola Luigi Bragazzi, Howard Amital, Richard Cuhtbert, Miriam Wittmann, Kassem Sharif, Tony Kenna, Matthew A. Brown, Darren Newton, Charlie Bridgewood, Dennis G. McGonagle
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Letter
Immunology
Dennis McGonagle, Kassem Sharif, Anthony O'Regan, Charlie Bridgewood
AUTOIMMUNITY REVIEWS
(2020)
Article
Rheumatology
Giovanni Damiani, Alessia Pacifico, Maurizio Rizzi, Pierachille Santus, Charlie Bridgewood, Nicola Luigi Bragazzi, Mohammed Adawi, Abdulla Watad
CLINICAL RHEUMATOLOGY
(2020)
Editorial Material
Critical Care Medicine
Dennis McGonagle, Sven Plein, James S. O'Donnell, Kassem Sharif, Charles Bridgewood
LANCET RESPIRATORY MEDICINE
(2020)
Review
Immunology
Dennis McGonagle, Kassem Sharif, Anthony O'Regan, Charlie Bridgewood
AUTOIMMUNITY REVIEWS
(2020)
Article
Medicine, General & Internal
S. R. Harrison, J. R. L. Klassen, C. Bridgewood, A. Scarsbrook, H. Marzo-Ortega, D. McGonagle
Summary: In 2020, 32.8% of ambulatory patients with suspected pulmonary embolism presenting with chest pain exhibited parenchymal changes, with 7.5% diagnosed as COVID-19 infection based on imaging criteria, despite the absence of other COVID-19 symptoms.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Rheumatology
Dennis McGonagle, Athimalaipet Ramanan, Charlie Bridgewood
Summary: This article discusses macrophage activation syndrome (MAS) in relation to other cytokine storm scenarios, providing a framework for understanding MAS within the spectrum of innate and adaptive immunity in the context of gain or loss of immune function.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Immunology
Tobias Russell, Charlie Bridgewood, Hannah Rowe, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: In AS and nrAxSpA, spinal inflammation may lead to excessive entheseal tissue repair and new bone formation, involving local tissue immune responses and cytokines like TNF and IL-17. Normal skeletal homeostasis involves tissue microdamage, micro-inflammation, and repair, with resident immune cells capable of regulating tissue repair. Genetic studies and animal models suggest redundant roles for TNF and IL-17 in physiological tissue repair, but in diseases like AS, immune system overactivity of these cytokines can lead to exuberant tissue repair responses.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Editorial Material
Dermatology
Lennart M. Roesner, Charlie Bridgewood, Dennis McGonagle, Miriam Wittmann
Summary: In a new article, Bakker et al. (2021) demonstrate how dupilumab specifically targets skin-homing T cells, the key cells in atopic dermatitis, using deep immune cell phenotyping.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Charlie Bridgewood, Miriam Wittmann, Tom Macleod, Abdulla Watad, Darren Newton, Kanchan Bhan, Howard Amital, Giovanni Damiani, Sami Giryes, Nicola Luigi Bragazzi, Dennis McGonagle
Summary: The use of Dupilumab is associated with seronegative inflammatory arthritis and psoriasis, but not with classic polygenic humoral autoimmune diseases. Pathway analysis suggests that Dupilumab may affect certain cytokine pathways and contribute to immune disorders and other pathological processes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Clinical Neurology
James F. M. Meaney, James S. O'Donnell, Charles Bridgewood, Joseph Harbison, Dennis McGonagle
Summary: Neurological manifestations, particularly strokes, are common in COVID-19, and a novel mechanism suggests that pulmonary vein clots can embolize to the brain, leading to large vessel occlusion strokes.
Review
Medicine, General & Internal
Charlie Bridgewood, Giovanni Damiani, Kassem Sharif, Abdulla Watad, Nicola L. Bragazzi, Luca Quartuccio, Sinisa Savic, Dennis McGonagle
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2020)
Letter
Rheumatology
Dennis McGonagle, James S. O'Donnell, Kassem Sharif, Paul Emery, Charles Bridgewood
LANCET RHEUMATOLOGY
(2020)
Review
Rheumatology
Dennis McGonagle, James S. O'Donnell, Kassem Sharif, Paul Emery, Charles Bridgewood
LANCET RHEUMATOLOGY
(2020)