Article
Cell Biology
Tobias Russell, Abdulla Watad, Charlie Bridgewood, Hannah Rowe, Almas Khan, Abhay Rao, Peter Loughenbury, Peter Millner, Robert Dunsmuir, Richard Cuthbert, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: The study found that spinal enthesis contains MSCs with different in vitro functionalities, especially in response to IL-17A. IL-17A enhances osteogenesis and CCL20 production, while reducing adipogenesis.
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Tobias Russell, Charlie Bridgewood, Hannah Rowe, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: In AS and nrAxSpA, spinal inflammation may lead to excessive entheseal tissue repair and new bone formation, involving local tissue immune responses and cytokines like TNF and IL-17. Normal skeletal homeostasis involves tissue microdamage, micro-inflammation, and repair, with resident immune cells capable of regulating tissue repair. Genetic studies and animal models suggest redundant roles for TNF and IL-17 in physiological tissue repair, but in diseases like AS, immune system overactivity of these cytokines can lead to exuberant tissue repair responses.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Cell Biology
Rong Xu, Laura C. Jacques, Shadia Khandaker, Miguel Leon-Rios, Daan Beentjes, Xiaoqing Wei, Neil French, Daniel R. Neill, Aras Kadioglu
Summary: Streptococcus pneumoniae is a highly morbid and mortal pathogen. Activation of pulmonary Treg cells with upregulated TNFR2 expression occurs upon pneumococcal infection. Deficiency in TNFR2 compromises Treg cell responses, leading to highly activated IL-17A-producing y8 T cell responses and increased susceptibility to disease. Blocking IL-17A at early stage of infection improves survival in TNFR2-deficient mice.
Article
Gastroenterology & Hepatology
Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Felix Neuhaus, Teresa Ruckenbrod, Anna Hupfer, Hartmann Raifer, Matthias Klein, Tobias Bopp, Petra Ina Pfefferle, Rajkumar Savai, Immo Prinz, Ari Waisman, Sonja Moos, Hyun-Dong Chang, Stefan Heinrich, Detlef K. Bartsch, Malte Buchholz, Shiv Singh, Mengyu Tu, Lukas Klein, Christian Bauer, Robert Liefke, Andreas Burchert, Ho-Ryun Chung, Philipp Mayer, Thomas M. Gress, Matthias Lauth, Matthias Gaida, Magdalena Huber
Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and immune cells. In this study, the role of a non-canonical CD8(+) T-cell subpopulation producing IL-17A (Tc17) in PDAC was evaluated.
Article
Oncology
Catherine S. Forconi, David H. Mulama, Priya Saikumar Lakshmi, Joslyn Foley, Juliana A. Otieno, Jonathan D. Kurtis, Leslie J. Berg, John M. Ong'echa, Christian Muenz, Ann M. Moormann
Summary: Children diagnosed with endemic Burkitt lymphoma (eBL) show deficient IFN-? responses to EBNA1, but the specific contributions of immune-regulatory cytokines and EBNA1-specific T cell phenotypes have not been clearly characterized. Our study compared cytokine expression and T cell memory profiles in response to EBNA1 and a malaria antigen among eBL patients and healthy children with different malaria exposures. Results indicate that eBL children have lower rates of EBNA1-specific IFN-? producing CD4(+) T cells compared to healthy children with high or low malaria exposures.
Article
Biochemistry & Molecular Biology
Laura Perucho, Laura Icardi, Elisabetta Di Simone, Veronica Basso, Alessandra Agresti, Amaia Vilas Zornoza, Teresa Lozano, Felipe Prosper, Juan Jose Lasarte, Anna Mondino
Summary: Sin3A plays a crucial role in regulating the differentiation of Th17 cells and the development of lymphocytes.
Article
Geriatrics & Gerontology
Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao, Peichang Wang
Summary: IL-17A promotes the progression of AD by inducing the secretion of TNF-α and exacerbating neuroinflammation through the TLR4/NF-κB signaling pathway and microglial activation. In addition, injection of IL-17A antibody significantly improves cognitive function in APP/PS1 mice.
Article
Immunology
Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit
Summary: CD4(+) T cells play a role in immune responses depending on the environment and stage, with nutrient availability also impacting their functionality. TNFR2 has been identified as key in regulating T cells, particularly Tregs. This study provides new evidence for the role of TNFR2 in metabolic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hung-Lin Chen, Chia-Hui Lo, Chi-Chun Huang, Meng-Ping Lu, Po-Yuan Hu, Chang-Shan Chen, Di-Yen Chueh, Peilin Chen, Teng-Nan Lin, Yuan-Hsin Lo, Yu-Ping Hsiao, Daniel K. Hsu, Fu-Tong Liu
Summary: The study found that the expression of galectin-7 is reduced in skin lesions of psoriasis patients, and IL-17A and TNF-alpha suppress galectin-7 expression in human keratinocytes. Galectin-7 attenuates the production of inflammatory mediators by keratinocytes via the microRNA-146a/ERK pathway when cells are stimulated with IL-17A. Fluvastatin was identified as an inducer of galectin-7 expression and showed potential in reducing IL-6 and IL-8 production induced by IL-17A.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Benjamin Ehst, Zhiping Wang, Justin Leitenberger, Danielle McClanahan, Rachel De La Torre, Erika Sawka, Alex G. Ortega-Loayza, Jennifer Strunck, Teri Greiling, Eric Simpson, Yuangang Liu
Summary: IL-23 plays a crucial role in Th17 immunity and inflammatory responses, especially in diseases like psoriasis. While dendritic cells are considered the main source of IL-23 in psoriasis, there is controversy surrounding the expression of IL-23 in psoriatic keratinocytes. Research has shown that a combination of TNF alpha and IL-17A can induce IL-23 production in human keratinocytes, with enhanced effects in psoriatic keratinocytes and EGFR signaling.
Article
Medicine, General & Internal
Georgios Kokolakis, Kamran Ghoreschi
Summary: The understanding of immunopathogenesis of psoriasis has led to the development of targeted therapies, including IL-17 antibodies which have been established for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis. This study presents two patients with psoriasis who lost response to previous treatments, but responded well to bimekizumab, a new antibody that neutralizes both IL-17A and IL-17F. The fast response and lack of side effects suggest the important role of IL-17F and the potential benefit of bimekizumab in non-responders to other anti-IL-17 therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomas Raul Wiche Salinas, Annie Gosselin, Laurence Raymond Marchand, Etiene Moreira Gabriel, Olivier Tastet, Jean-Philippe Goulet, Yuwei Zhang, Dragos Vlad, Hanane Touil, Jean-Pierre Routy, Mariana G. Bego, Mohamed El-Far, Nicolas Chomont, Alan L. Landay, Eric A. Cohen, Cecile Tremblay, Petronela Ancuta
Summary: The crosstalk between IECs and Th17-polarized CD4(+) T cells is crucial for mucosal homeostasis, with IL-17A acting in synergy with TNF to promote HIV trans-infection and outgrowth, while also inducing a pro-inflammatory and pro-viral molecular signature.
Article
Immunology
Tianzhen He, Yi Zhao, Peng Zhao, Liwen Zhao, Jaffry Zakaria, Ke Wang
Summary: TNFR2, preferentially expressed by Tregs, is a significant surface marker for the activation and expansion of Tregs. There are three required signaling pathways for the inhibitory effect of Tregs, including NF-κB, MAPK, and PI3K-Akt pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Lauren K. Ridley, Mark C. Hwang, John D. Reveille, Lianne S. Gensler, Mariko L. Ishimori, Matthew A. Brown, Mohammad H. Rahbar, Amirali Tahanan, Michael M. Ward, Michael H. Weisman, Thomas J. Learch
Summary: This study investigated a subgroup of patients with ankylosing spondylitis (AS) who had long-standing disease and fused sacroiliac (SI) joints and found that females and males with early symptom onset had less radiographic damage in the SI joints. All 23 patients without syndesmophytes were HLA-B27 positive.
JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Genetics & Heredity
Zhixiu Li, Allan F. F. McRae, Geng Wang, Jonathan J. J. Ellis, Jessica Whyte, Tony J. J. Kenna, Matthew A. A. Brown, David M. M. Evans
Article
Health Care Sciences & Services
Jude Dzevela Kong, Ugochukwu Ejike Akpudo, Jake Okechukwu Effoduh, Nicola Luigi Bragazzi
Summary: This paper explores the role of artificial intelligence (AI) and big data analytics (BDA) in addressing clinical public and global health needs in the Global South. It highlights the interdisciplinary nature of clinical public health and its focus on resource-limited settings. The paper emphasizes the potential of AI and BDA in addressing healthcare challenges and promoting health equity.
Review
Health Care Sciences & Services
Maha Sellami, Luca Puce, Nicola Luigi Bragazzi
Summary: Participating in sports activities and/or competitions can be challenging for the immune system of disabled athletes due to various reasons such as chronic inflammatory and immunodepression-secondary immune deficiency-state imposed by the disability, impact of disability on physical fitness and well-being, and variability in exercise parameters. Moderate intensity exercise is accompanied by optimal immunity, while intense training without sufficient recovery can lead to temporary immunosuppression. Research on disabled athletes is limited, but studies suggest behavioral, dietary, and training strategies to limit exercise-induced immunosuppression. However, there is a need for further high-quality investigations in this population.
Review
Health Care Sciences & Services
Luca Puce, Carlo Biz, Carlo Trompetto, Lucio Marinelli, Antonio Curra, Luca Cavaggioni, Matteo Formica, Vittorio Vecchi, Maria Chiara Cerchiaro, Khaled Trabelsi, Nicola Luigi Bragazzi, Pietro Ruggieri
Summary: Para-rowing is a rowing format that allows people with disabilities to participate, thanks to adapted equipment and rules. It made its debut at the 2008 Paralympic Games. Rigorous research is needed to support the pursuit of sporting excellence by para-rowers.
Review
Multidisciplinary Sciences
Haitham Jahrami, Zahra Saif, Khaled Trabelsi, Nicola L. Bragazzi, Michael V. Vitiello
Summary: NOMOPHOBIA is a psychological condition in which individuals fear losing the ability to use or reach their mobile phones. The NMP-Q is a commonly used survey for assessing symptoms related to nomophobia. A meta-analysis on the NMP-Q reveals excellent internal consistency and structural validity of four factors.
Article
Multidisciplinary Sciences
Zahra M. Nia, Nicola L. Bragazzi, Jianhong Wu, Jude D. Kong
Summary: After the COVID-19 pandemic, the world is recovering, but a new virus called Monkeypox is spreading globally, posing a threat of a new pandemic. Twitter has been used successfully for predicting and controlling outbreaks, and this study provides a publicly available dataset of 2,400,202 tweets from May to December 2022. The dataset will help researchers understand the news, patterns, and ongoing discussions of Monkeypox on social media, identify hotspots, and contain the virus.
Review
Dermatology
Johannes Pawlowski, Janina Beczinski, Henner Stege, Caroline Mann, Florian Butsch, Bilal Al-Nawas, Sebahat Kaya, Miriam Wittmann
Summary: Lichen planus is a complex dermatological condition that affects the skin, nails, and mucosa. The exact cause is still unclear and treatment options are limited. Severe oral mucosal involvement is challenging to manage and requires regular screening for potential cancer development.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yonatan Shneor Patt, Adi Lahat, Paula David, Chen Patt, Rowand Eyade, Kassem Sharif
Summary: Celiac disease is a complex immune-mediated disease with various pathological manifestations that extend beyond gastrointestinal symptoms. The existing main treatment, a gluten-free diet, presents challenges and alternative therapies are being developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Maamer Slimani, Hela Znazen, Amri Hammami, Nicola Luigi Bragazzi
Summary: The aim of this study was to assess the effect of acute short- versus long-interval high-intensity interval training on cognitive performance and psychological states in secondary school students. The study found that short-interval HIIT had a positive impact on attention performance, while long-interval HIIT had positive effects on attention and error count. Additionally, fatigue and vigor differed between different training conditions.
Article
Health Care Sciences & Services
Carlo Biz, Assunta Pozzuoli, Elisa Belluzzi, Davide Scucchiari, Nicola Luigi Bragazzi, Alessandro Rossin, Mariachiara Cerchiaro, Pietro Ruggieri
Summary: This study compared the clinical and radiographic outcomes of operative and non-operative treatment for acute displaced midshaft clavicle fractures (ADMCFs), and verified the effectiveness of the institutional treatment protocol. The results showed that conservative treatment had better clinical outcomes, while return to sports was longer in the surgical group. However, both groups achieved good mid-term clinical results without any signs of non-union.
Article
Health Care Sciences & Services
Filippo Cotellessa, Luca Puce, Matteo Formica, Maria Cesarina May, Carlo Trompetto, Marco Perrone, Andrea Bertulessi, Vittorio Anfossi, Roberto Modenesi, Lucio Marinelli, Nicola Luigi Bragazzi, Laura Mori
Summary: This study assessed the effectiveness of a new preventive protocol on groin pain syndrome (GPS) for youth soccer players. The protocol included targeted stretching and strengthening exercises for the adductor and core muscles. The results showed a decrease in the incidence of severe GPS and increased muscle strength, although the overall reduction in the risk of developing GPS was not statistically significant.
Review
Emergency Medicine
Miroslaw Dabkowski, Damian Swieczkowski, Michal Pruc, Basar Cander, Mehmet Gul, Nicola Bragazzi, Lukasz Szarpak
Summary: This systematic review and meta-analysis assessed the impact of the COVID-19 pandemic on out-of-hospital cardiac arrest (OHCA). The results showed that COVID-19 was associated with a higher incidence of OHCA at home, longer emergency medical services arrival time and on-scene time, as well as a reduction in shockable rhythms. Survival rates were lower during the COVID-19 period, both in terms of hospital admission and hospital discharge, with a decrease in the rate of good neurological outcome.
EURASIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Obstetrics & Gynecology
Hadeel A. A. Ghazzawi, Omar Alhaj, Nicola Bragazzi, Lana Alnimer, Haitham Jahrami
Summary: This study examined the relationship between nutrient consumption and the severity of menstrual cycle symptoms in 204 regularly menstruating women. Results showed that intake of polyunsaturated fatty acids was associated with milder physical, psychological, and functioning symptoms. Thiamine intake prevented psychological, physiological, and functioning symptoms. Saturated fat, iron, and niacin intakes increased the risk of experiencing psychological symptoms during the menstrual cycle.
Article
Medicine, General & Internal
Einat Savin, Niv Ben-Shabat, Asaf Levartovsky, Adi Lahat, Mahmud Omar, Omer Gendelman, Merav Lidar, Abdulla Watad, Shomron Ben-Horin, Uri Kopylov, Kassem Sharif
Summary: The study found that making adjustments to biologic therapy at the time of the second diagnosis was associated with a higher rate of improvement in AS/IBD at the 90-day follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)