Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Chemistry, Medicinal
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang, Liang Ouyang
Summary: Parkinson's disease (PD) is a multifactorial disease caused by a complex interplay between genetic and epigenetic factors. Recent studies have revealed the epigenetic mechanisms involved in PD, such as DNA methylation, histone modifications, and microRNA (miRNA) regulation. Epigenetic regulators could be potential therapeutic targets in neurodegenerative disorders. This review summarizes the mechanisms of epigenetic regulation in PD and discusses the use of inhibitors and activators of these regulators, as well as the neuroprotective effects of small molecule epigenetic modulators. Additionally, the contribution of miRNAs to the underlying mechanisms of PD and miRNA-based therapies are also discussed.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Judy S. Crabtree
Summary: Gastroenteropancreatic neuroendocrine neoplasms are rare and diverse tumors associated with genetic disorders and epigenetic regulation. Epigenetic signatures can be used as biomarkers for diagnosis and as targets for the development of new treatment approaches.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Priscilla Van den Ackerveken, Alison Lobbens, Jean-Valery Turatsinze, Victor Solis-Mezarino, Moritz Voelker-Albert, Axel Imhof, Marielle Herzog
Summary: Alteration of histone post-translational modifications (PTMs) is crucial in human cancer, particularly in colorectal cancer (CRC). A new enrichment method was developed to isolate circulating nucleosomes from plasma for proteomic analysis, revealing distinct histone PTMs in CRC patients. Methylation of histone H3K9 and H3K27, acetylation of histone H3, and citrullination of histone H2A1R3 were found to be upregulated in CRC patients, with potential for biomarker discovery.
SCIENTIFIC REPORTS
(2021)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Environmental Sciences
Bozena Bukowska, Ewelina Wozniak, Paulina Sicinska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Glyphosate has been shown to induce epigenetic changes that may be associated with carcinogenesis. These changes include alterations in DNA methylation, gene expression, chromatin structure, and the regulation of non-coding RNA molecules. These epigenetic changes can persist over time and be passed on to future generations, potentially leading to the development of diseases such as prostate disease or obesity. More research is needed to fully understand the metabolic effects of these changes on organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Genetics & Heredity
Priyanka Kumari, Sajid Khan, Ishfaq Ahmad Wani, Renu Gupta, Susheel Verma, Pravej Alam, Abdullah Alaklabi
Summary: Epigenetics refers to heritable changes in gene expression patterns without altering the DNA sequence. These changes are induced by DNA methylation, histone modification, and RNA-mediated mechanisms, and play a dynamic role in plant development, adaptation to environmental changes, and reproduction.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Junyuan Xie, Li Gan, Bingjian Xue, Xinxing Wang, Xinhong Pei
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide. Non-coding RNAs, especially lncRNAs, have been found to play important roles in breast cancer. The study of epigenetic modifications has also contributed to the understanding of the role of ncRNAs in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Environmental Sciences
Pooja Ratre, Prachi Chauhan, Arpit Bhargava, Rajnarayan Tiwari, Suresh Thareja, Rupesh Kumar Srivastava, Pradyumna Kumar Mishra
Summary: Air pollution poses a serious threat to human health, contributing to various chronic diseases. Vitamins, through their effects on the epigenomic landscape, may help mitigate the adverse effects. However, there is a need to improve the clinical utility of vitamins as epigenetic modifiers. This review summarizes the role of vitamins and discusses the importance of nano-engineered vitamins as potential drugs to address the long-term effects of air pollution toxicity.
REVIEWS ON ENVIRONMENTAL HEALTH
(2023)
Review
Chemistry, Multidisciplinary
Pooja Ratre, Bulbul Jain, Roshani Kumari, Suresh Thareja, Rajnarayan Tiwari, Rupesh Kumar Srivastava, Irina Yu Goryacheva, Pradyumna Kumar Mishra
Summary: Graphene quantum dots (GQDs) are natural crystalline semiconductors that have unique physical and chemical properties. Compared to inorganic quantum dots, GQDs have advantages such as biocompatibility and low toxicity, making them promising materials for nanophotonic applications. Their photonic compliant properties make GQDs useful as novel probes for biomolecule detection and molecular interaction studies. GQDs-based strategies in liquid biopsy could be a step towards early diagnosis, prognosis, treatment monitoring, and outcome prediction of non-communicable diseases.
Review
Chemistry, Analytical
Alexandra I. Arzhanukhina, Nadezhda S. Komova, Anton M. Pavlov, Alexey A. Serdobintsev, Tatiana Yu. Rusanova, Irina Yu. Goryacheva
Summary: Surface-enhanced Raman spectroscopy (SERS) is a powerful and up-to-date method in analytical chemistry, known for its high sensitivity and fingerprint recognition capabilities. In the medical field, SERS has been actively developed for label-free analysis of biologically important substances and potential on-site detection of toxins and food safety. Plasmonic nanostructures are essential for obtaining SERS signals, and electrospun nanofibers are a promising substrate due to their various advantages. This review summarizes the methods of incorporating plasmonic nanostructures into electrospun nanofiber substrates and provides detailed insights into the analytical applications of SERS-active electrospun nanofibers with embedded nanostructures for biologically significant molecules. Furthermore, the future prospects of these substrates in bioanalysis are discussed as the most promising area in analytical chemistry.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Afreen Rehman, Roshani Kumari, Arunika Kamthan, Rajnarayan Tiwari, Rupesh Kumar Srivastava, Francois H. van der Westhuizen, Pradyumna Kumar Mishra
Summary: The exposure to airborne particulate matter is associated with the deterioration of cardiovascular function, which is driven by the impairment of mitochondrial-nuclear crosstalk due to aberrant redox signaling. The methylation of mitochondrial DNA (mtDNA) plays a role in the alteration of mitochondrial bioenergetics and transcriptional regulatory processes, particularly in highly metabolic active tissues like the heart. Previous studies have shown that mtDNA methylation has contradictory effects on cardiovascular pathologies related to air pollution, contributing to systemic inflammation and various co-morbidities.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemical Research Methods
P. A. Demina, O. A. Sindeeva, A. M. Abramova, M. S. Saveleva, G. B. Sukhorukov, I. Y. Goryacheva
Summary: This article investigates the performance of fluorescent photoconvertible polymer markers under different laser conditions and successfully achieves cell labeling. The authors describe the performance characteristics of fluorescent polymer capsules as an aqueous suspension and as a single capsule, and demonstrate the potential of these fluorescent markers for long-term live cell labeling.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Chemistry, Analytical
Alexey Markin, Alexandra I. Arzhanukhina, Natalia E. Markina, Irina Yu Goryacheva
Summary: This article reviews the advantages and issues of electrochemical surface-enhanced Raman spectroscopy (EC-SERS) analysis. The ability to regulate analyte adsorption-desorption by electrode polarization provides additional control over the analytical signal and allows for fast and easy fabrication, cleaning, and regeneration of the SERS-active surface. However, EC-SERS analysis is less frequently used for routine analysis. The article collects relevant analytical reports and analyzes the limitations that restrict its practical application.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Yuliya A. Podkolodnaya, Alina A. Kokorina, Irina Yu. Goryacheva
Summary: In this study, luminescent composite SiO2 nanoparticles/CNSs were synthesized by targeted formation of a molecular fluorophore on the surface of a silica matrix. The synthesis of fluorophore doped composite allows for easy control of particle shape, size, and surface functionality.
Article
Cell Biology
Zaffar Azam, Leena Sapra, Kalpana Baghel, Niharika Sinha, Rajesh K. Gupta, Vandana Soni, Chaman Saini, Pradyumna K. Mishra, Rupesh K. Srivastava
Summary: Osteoporosis is a skeletal disease characterized by low bone density, bone degeneration, and weakened bone strength. Cissus quadrangularis (CQ) is a traditional medicinal herb that has potential protective effects on bone health. However, the cellular mechanisms underlying its effects on the immune system and bone health have not been fully understood.
Review
Cell Biology
Rupesh K. K. Srivastava, Leena Sapra, Pradyumna K. K. Mishra
Summary: The renewed interest in intermediate metabolism and cellular bioenergetics is driven by the increasing prevalence of metabolic illnesses worldwide. Recent studies show that energy metabolism in bone cells is interconnected with other metabolic control centers, highlighting the importance of exploring this field.
Review
Chemistry, Analytical
Pooja Ratre, Nazim Nazeer, Roshani Kumari, Suresh Thareja, Bulbul Jain, Rajnarayan Tiwari, Arunika Kamthan, Rupesh K. Srivastava, Pradyumna Kumar Mishra
Summary: Non-communicable diseases (NCDs) pose potential risks to humans due to sedentary lifestyles and inaccurate diagnoses. Point-of-care technologies for early NCD detection can significantly reduce the burden and revolutionize clinical intervention and healthcare provision. An imbalance in circulating cell-free microRNAs (ccf-miRNA) has been observed in NCDs, and nanomaterial-based fluorescence nano-biosensors, particularly those using carbon nanodots (CNDs), offer promising solutions for their effective sensing.
Article
Chemistry, Analytical
Svetlana A. Mescheryakova, Ivan S. Matlakhov, Pavel D. Strokin, Daniil D. Drozd, Irina Yu. Goryacheva, Olga A. Goryacheva
Summary: Doxorubicin (DOX) is a commonly used anti-tumor drug in chemotherapy, but it has high cardio-, neuro- and cytotoxicity. Therefore, continuous monitoring of DOX concentrations in biofluids and tissues is important. This study demonstrates the capabilities of analytical nanosensors based on the quenching of fluorescence of alloyed CdZnSeS/ZnS quantum dots (QDs) for operative DOX detection. Optimized turn-off fluorescence nanosensors were developed for direct DOX determination in undiluted human plasma.
Article
Chemistry, Physical
Natalia E. Markina, Irina Yu. Goryacheva, Alexey V. Markin
Summary: The paper discusses the use of CD-modified AgNPs for the improvement of MTX determination through SERS. The CD-modified AgNPs increased the SERS signal of MTX in neutral media, simplifying the analysis and reducing the influence of endogenous components. The assay showed satisfactory precision, accuracy, and limit of detection for MTX determination in real human urine samples.
COLLOIDS AND INTERFACES
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Pradyumna Kumar Mishra, Prasan Kaur
Article
Chemistry, Multidisciplinary
Pooja Ratre, Nazim Nazeer, Arpit Bhargava, Suresh Thareja, Rajnarayan Tiwari, Vinay Singh Raghuwanshi, Pradyumna Kumar Mishra
Summary: This study developed an optical nanobiosensor for detecting the competitive endogenous RNA network in breast cancer. The sensor showed high specificity and applicability, allowing for identification of target RNAs in blood samples with a low detection limit.
Review
Oncology
Pooja Ratre, Swanand Kulkarni, Sweety Das, Chengyuan Liang, Pradyumna Kumar Mishra, Suresh Thareja
Summary: This review provides an overview of coumarin as an ideal template for designing novel anti-breast cancer compounds and discusses the diversity of coumarin as a target for aromatase. The structure-activity relationship analysis of coumarin core is summarized to identify the essential pharmacophoric features for developing aromatase inhibitors. The review also covers key synthesis techniques to aid in designing and developing analogues with significant anti-breast cancer properties.