Article
Chemistry, Multidisciplinary
Yanjie Zhang, Yanguang Li, Lei Liu, Quanhu Guo, Rongjian Sa, Mei Zhang, Benyong Lou
Summary: Two polymorphic cocrystals of palmatine chloride with racemic hesperetin (Form I and Form II) were prepared and investigated, showing different supramolecular arrangements despite similar hydrogen-bonding interactions. Cocrystal formation decreases the solubility of palmatine chloride and improves the solubility of hesperetin, allowing for sustained release of palmatine chloride and enhanced release of hesperetin in pure water.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Enrico Spoletti, Vivek Verma, Chiara Cappuccino, Matteo Lusi
Summary: The search for solid solutions of class-two insulin secretagogues tolbutamide and chlorpropamide reveals a rare case of monotropic polymorphism for the mixed crystals. The solid solutions exhibit superior solubility advantage over pure drugs, suggesting potential applications as highly soluble co-drug formulations.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Jiaquan Li, Yangjia Huang, Qi An, Wenyu Li, Jianting Li, Hongji Liu, Dezhi Yang, Yang Lu, Zhengzheng Zhou
Summary: Multi-component pharmaceutical systems like cocrystal and salt are popular for regulating the physicochemical properties of active pharmaceutical ingredients (APIs). This study discovered a novel drug-drug salt of lamotrigine-tolfenamic acid with two polymorphs and two solvates. The physicochemical properties of the different crystal forms were characterized and compared. The findings provide new choices for formulation development.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Carlos Henrique de Moura Oliveira, Jennifer Tavares Jacon Freitas, Iara Maria Landre Rosa, Antonio Carlos Doriguetto
Summary: This study systematically characterized two polymorphs of sulfamethoxazole and discovered the crystallization process of SMZII from molten material, as well as the solid-state transformation of SMZII to SMZI. It also revealed the equivalent solubilities of SMZI and SMZII, attributed to a phase transition mechanism between the two polymorphs.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Qingyang Fan, Ruida Zhao, Yingbo Zhao, Yanxing Song, Sining Yun
Summary: This work investigates two boron nitride polymorphs, P-62m BN and I-43d BN, and finds that they are mechanically, thermally, and dynamically stable. Both P-62m BN and I-43d BN are wide band gap semiconductors, with P-62m BN being an ultrawide band gap semiconductor exceeding the band gap of Ga2O3 and diamond. Meanwhile, the band gap of I-43d BN is larger than that of ZnO, GaN, and SiC. Both polymorphs are brittle materials and exhibit different degrees of elastic anisotropy in Young's modulus. X-ray diffraction patterns are also studied for further distinction.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Materials Science, Ceramics
Xiang Liu, Youjun Lu, Qian Xu, Lutong Yang, Hongfang Shen, Wenzhou Sun, Xiao Zhang, Yanmin Wang
Summary: High-entropy (HfZrTiNbTa)N powders with submicron-sized particles, a single face-centered cubic (fcc) structure, and narrow size distribution were synthesized via nitride (Si3N4) thermal reduction with soft mechano-chemical assistance. The high-entropy bulk nitride ceramics obtained from these powders exhibit superior properties.
JOURNAL OF ADVANCED CERAMICS
(2023)
Article
Chemistry, Multidisciplinary
Yulong Gu, Xiaolin Li, Gan Ye, Zhen Gao, Wei Xu, Yinyong Sun
Summary: This study successfully achieved the accelerated and scalable synthesis of UiO-66(Zr) under solvent-free conditions with the assistance of inorganic salts. The product obtained has a large surface area and high yield, suitable for large-scale production. By adjusting various parameters and types of inorganic salts, the synthesis conditions were optimized, and the approach can also be extended to prepare functionalized UiO-66(Zr) materials.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kyle B. Pekar, Jonathan B. Lefton, Christina A. McConville, Jewel Burleson, Daniel Sethio, Elfi Kraka, Tomce Runcevski
Summary: A 1:1 coamorphous formulation of creatine and citric acid, as well as a cocrystalline formulation, were successfully synthesized through mechanochemical methods in this study. The cocrystal showed significantly higher aqueous solubility and lower acidity compared to commercial creatine monohydrate and creatine hydrochloride, suggesting it may be a more marketable creatine supplement formulation.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Joanna S. Stevens
Summary: Crystallization of 4,4'-bipyridine with squaric acid leads to the formation of four distinct colored complexes with varying degrees of proton transfer.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Franziska Kamm, Florian Pielnhofer, Marc Schlosser, Arno Pfitzner
Summary: Two polymorphs of Na4Si2Se6 with different crystalline structures were synthesized. The Na4Si2Se6-tP24 polymorph crystallizes in the tetragonal space group P42/mcm, while the Na4Si2Se6-oP48 polymorph crystallizes in the orthorhombic space group Pbca. The structures and properties of both polymorphs were investigated using X-ray diffraction and density functional theory modeling. The Na4Si2Se6-oP48 polymorph exhibited ionic conductivity and an activation energy of EA = 0.54(2) eV.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Abraham Colin-Molina, Jessica Arcudia, Eliseo R. Lopez-Lopez, Marcus J. Jellen, Ma Carmen Garcia-Gonzalez, Gabriel Merino, Braulio Rodriguez-Molina
Summary: The study reveals the non-isotropic motion of two constituents within crystals, with DABCO rotating rapidly over an N-H center dot N axis and THF preferentially rotating around a weak C-H center dot O axis perpendicular to that of DABCO. Dynamic characterization shows rapid jumps and rotations, indicating potential implications for future applications of multicomponent solids with regulated dynamics.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Psychiatry
Mark Weiser, Daisy Zamora, Linda Levi, Igor Nastas, Ilan Gonen, Paull Radu, Valentin Matei, Anatol Nacu, Larisa Boronin, Michael Davidson, John M. Davis
Summary: Two 16-week double-blind randomized placebo-controlled trials were conducted to evaluate the efficacy of adjunctive aspirin in treating schizophrenia. Both studies did not find statistically significant differences in primary or secondary outcomes between aspirin and placebo. Meta-analysis also showed no significant improvement in symptoms of schizophrenia with adjunctive aspirin therapy compared to placebo.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Xiangjun Shi, Yu Deng, Zijuan Wang, Xinyue Liu, Qifeng Chen, Junjie Peng, Xiaoyi Xing, Weike Su
Summary: In this study, two new polymorphs (form X and form Y) of nilotinib were prepared by melt crystallization. The solubility and dissolution rate of form X were significantly increased compared to form A, and the solubility and dissolution rate of form Y were also improved. These findings provide more options for formulation development of nilotinib.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yanna Chen, Wenyao Zhang, Donghai An, Maierhaba Abudoureheman, Zhaohui Chen, Hongyu Mi
Summary: A new polymorph of Ba3Zn2(BO3)(3)F, alpha-Ba3Zn2(BO3)(3)F, was synthesized and studied for its structural properties, including an anomalous phase transition with different densities in the two polymorphous phases. This was confirmed by detailed structural analyses using powder X-ray diffraction and differential scanning calorimetry.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Rikuo Kajiwara, Koji Hirano, Masahiro Miura
Summary: A new method for the cyanation of phenols with ortho-selectivity has been developed using Cu-mediated C-H activation and ethyl cyanoformate. The success of this method lies in the introduction of a bidentate auxiliary that is easily attachable, detachable, and recyclable. This protocol shows tolerance towards various carbonyl functional groups, which were incompatible with previous methods using Lewis acid promoters.
Article
Chemistry, Multidisciplinary
Shalisa M. Oburn, Nathan P. Bowling, Eric Bosch
CRYSTAL GROWTH & DESIGN
(2015)
Article
Chemistry, Multidisciplinary
Shalisa M. Oburn, Dale C. Swenson, S. V. Santhana Mariappan, Leonard R. MacGillivray
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Shalisa Malane Oburn, Dale Swenson, Leonard MacGillivray
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2017)
Article
Chemistry, Multidisciplinary
Shalisa M. Oburn, Eric Bosch
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Gonzalo Campillo-Alvarado, Tighe D. Didden, Shalisa M. Oburn, Dale C. Swenson, Leonard R. MacGillivray
CRYSTAL GROWTH & DESIGN
(2018)
Article
Chemistry, Multidisciplinary
Kristin M. Hutchins, Thilini P. Rupasinghe, Shalisa M. Oburn, Kamal K. Ray, Alexei V. Tivanski, Leonard R. MacGillivray
Article
Biochemistry & Molecular Biology
Joseph W. Bennett, Michaella E. Raglione, Shalisa M. Oburn, Leonard R. MacGillivray, Mark A. Arnold, Sara E. Mason
Article
Polymer Science
Margaret C. Gerthoffer, Bohan Xu, Sikai Wu, Jordan Cox, Steven Huss, Shalisa M. Oburn, Steven A. Lopez, Vincent H. Crespi, John Badding, Elizabeth Elacqua
Summary: Recently discovered diamond nanothreads offer a stiff backbone formed through the solid-state pressure-induced polymerization of simple aromatics, which is unachievable in conventional polymer synthesis. The compression of co-crystals containing -OH and -CHO functional groups reveals the influence of functional group interactions and parallel stacking on the pressure-induced polymerization to form nanothreads.
Article
Chemistry, Multidisciplinary
Shalisa M. Oburn, Steven Huss, Jordan Cox, Margaret C. Gerthoffer, Sikai Wu, Arani Biswas, Morgan Murphy, Vincent H. Crespi, John V. Badding, Steven A. Lopez, Elizabeth Elacqua
Summary: This study presents a novel approach to synthesize nanotubes at lower pressures using photochemical methods. The photochemically mediated polymerization of pyridine and furan aromatic precursors allows for the formation of nanotubes at reduced pressures. The maximum pressure required for furan-derived nanotubes is reduced by 1.9-fold, and the pressure required for pyridine-derived nanotubes is reduced by 1.4-fold.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Margaret C. Gerthoffer, Sikai Wu, Bo Chen, Tao Wang, Steven Huss, Shalisa M. Oburn, Vincent H. Crespi, John Badding, Elizabeth Elacqua
Article
Chemistry, Multidisciplinary
Shalisa M. Oburn, Carlos L. Santana, Elizabeth Elacqua, Ryan H. Groeneman