Antiatherogenic effects of Korean cabbage kimchi with added short arm octopus

Adimchae is a kimchi that contains more than 10% seafood. The lipid lowering and antiatherogenic effects of adimchae containing abalone or short arm octopus were compared with traditional Korean cabbage kimchi. Treated seafood was added to kimchi at 10%. ApoE KO mice (n=18) were fed an athrogenic diet supplemented with 10% freeze-dried cabbage kimchi (control), short arm octopus added kimchi (SK), or abalone added kimchi (AK) for 8 weeks. Plasma and hepatic triglyceride concentrations of SK group mice decreased significantly (p < 0.05), compared with control and AK group mice. Protein expression of hepatic fatty acid synthase (FAS) of SK group mice was significantly (p < 0.05) suppressed, compared with control group mice. Reduction of the fatty streak lesion size in the aortic sinus of SK mice was also significant (p < 0.05), compared with control group mice. Extra antiatherogenic effects of SK were due to decreased plasma lipid concentrations via suppression of the FAS activity.