Article
Cell Biology
Makoto Shirakawa, Alexander Zaboronok, Kei Nakai, Yuhki Sato, Sho Kayaki, Tomonori Sakai, Takao Tsurubuchi, Fumiyo Yoshida, Takashi Nishiyama, Minoru Suzuki, Hisao Tomida, Akira Matsumura
Summary: The study focuses on improving the accumulation and retention of boron in tumor tissues by designing novel PBL liposomes, providing promising candidates for BNCT treatment.
Article
Chemistry, Multidisciplinary
Kai Nishimura, Hideki Kashiwagi, Taiki Morita, Yusuke Fukuo, Satoshi Okada, Kazuki Miura, Yoshitaka Matsumoto, Yu Sugawara, Takayuki Enomoto, Minoru Suzuki, Kei Nakai, Shinji Kawabata, Hiroyuki Nakamura
Summary: In this study, a novel boron agent, PBC-IP, was developed for efficient targeting and accumulation in glioblastoma cells. PBC-IP showed higher accumulation and tumor growth suppression compared to L-4-boronophenylalanine (BPA) in animal models. When delivered via convection-enhanced delivery (CED), PBC-IP achieved high tumor accumulation and significantly improved survival rate in the glioma model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Mariya A. Vorobyeva, Maya A. Dymova, Darya S. Novopashina, Elena Kuligina, Valentina V. Timoshenko, Iaroslav A. Kolesnikov, Sergey Yu Taskaev, Vladimir A. Richter, Alya G. Venyaminova
Summary: The study successfully demonstrated the use of a 2'-F-RNA aptamer specific to human glioblastoma cells as a boron delivery agent for BNCT, resulting in effective reduction of cell viability. This proof of principle highlights the potential of aptamers for targeted delivery of boron-10 isotopes in BNCT, paving the way for the engineering of novel BNCT agents with high specificity and low toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Kai Nishimura, Suzanna Harrison, Kazuki Kawai, Taiki Morita, Kazuki Miura, Satoshi Okada, Hiroyuki Nakamura
Summary: This study developed a novel boron carrier that interacts with serum albumin in tumors, which has good water solubility and low cytotoxicity, and can generate high boron concentrations in tumors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Medicine, Research & Experimental
Qi Dai, QiYao Yang, Xiaoyan Bao, Jiejian Chen, Min Han, Qichun Wei
Summary: Boron neutron capture therapy (BNCT) is a promising biological targeted technique for cancer therapy, with good targeting and high effectiveness. It causes less damage to surrounding healthy tissue compared to other methods. Measuring boron concentration is crucial but current technology falls short. This review discusses the development of methods and imaging to improve measurement accuracy.
MOLECULAR PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Qi Dai, QiYao Yang, Xiaoyan Bao, Jiejian Chen, Min Han, Qichun Wei
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment method with good targeting and high efficacy. Measuring B-10 concentrations is vital for treatment effectiveness, but current technology needs improvement.
MOLECULAR PHARMACEUTICS
(2022)
Review
Oncology
Timothy D. Malouff, Danushka S. Seneviratne, Daniel K. Ebner, William C. Stross, Mark R. Waddle, Daniel M. Trifiletti, Sunil Krishnan
Summary: Boron neutron capture therapy (BNCT) is an emerging treatment modality that utilizes boron-10 to target tumors and has shown promising results in various cancer types in clinical studies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Kouhei Yoshikawa, Hideki Azuma, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Takeshi Nagasaki, Atsushi Ikeda
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment, but delivering effective boron agents is challenging. We developed hybrid nanoparticles called HBNGs that can efficiently deliver highly concentrated boron agents, surpassing the effectiveness of clinically used boron agent L-BPA/fructose complex in vitro. HBNGs accumulate in tumors and show high tumor selectivity, allowing for successful BNCT without tumor regrowth. The therapeutic efficacy of HBNGs is superior to L-BPA/fructose complex, making it a promising approach to cancer therapeutics.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Juan Li, Jianglong Kong, Sihan Ma, Jiacheng Li, Meiru Mao, Kui Chen, Ziteng Chen, Jiaxin Zhang, Yanan Chang, Hui Yuan, Tong Liu, Zizhu Zhang, Gengmei Xing
Summary: Novel boron-containing carbon dots (BCDs) were designed and prepared for boron neutron capture therapy (BNCT), encapsulated in exosomes (Exos) from macrophages to form BCD-Exos, achieving excellent therapeutic effects on brain glioma in mice models with 100% survival rate. Adjusted biodistribution of boron, enhanced T/N ratios, and precise match between boron and neutron exposure at the tumor site in vivo with fluorescence imaging of BCD-Exos contributed to the success of the treatment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biology
Andrea Monti Hughes, Jessica A. Goldfinger, Monica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, Maria E. Itoiz, Veronica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint
Summary: This study evaluated the distribution and therapeutic effect of MID:BSA in a hamster cheek pouch oral cancer model, demonstrating that the 15 mg B/kg dose reached therapeutically useful boron concentration values in the tumor and was well-tolerated, while the 30 mg B/kg dose induced high toxicity.
Review
Oncology
Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu, Junjie Wang
Summary: Boron neutron capture therapy (BNCT) is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. Effective BNCT requires a large number of B-10 atoms to be localized within tumor cells and an adequate number of thermal neutrons to be absorbed for lethal reactions to occur. Improvements in boron delivery and dosing paradigms remain essential for optimizing BNCT effectiveness.
RADIATION ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Takafumi Shigehira, Tadashi Hanafusa, Kazuyo Igawa, Tomonari Kasai, Shuichi Furuya, Hisakazu Nishimori, Yoshinobu Maeda, Hiroyuki Michiue, Atsushi Fujimura
Summary: Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells using the boron neutron capture reaction. The delivery dose of boron B-10 for anti-tumor effects in boron drugs is approximately 15-40 ppm, but its requirement for different boron drugs with different accumulation characteristics has not been extensively investigated.
ADVANCED THEORY AND SIMULATIONS
(2023)
Review
Chemistry, Medicinal
Paolo Coghi, Jinxin Li, Narayan S. Hosmane, Yinghuai Zhu
Summary: Boron neutron capture therapy (BNCT) is a promising treatment method in cancer therapy. The currently used boron compounds, l-boronophenylalanine (BPA) and sodium borocaptate (BSH), have their limitations and there is a need for next generation BNCT agents. Various boron compounds, including small molecules and macro/nano-vehicles, have been explored and have shown better success. This review summarizes the current knowledge of different boron compounds for BNCT application and provides a perspective for the future of BNCT in cancer treatment.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Physical
Dawid Kozien, Paulina Zeliszewska, Bozena Szermer-Olearnik, Zbigniew Adamczyk, Anna Wroblewska, Agnieszka Szczygiel, Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Elzbieta Pajtasz-Piasecka, Tomasz Tokarski, Grzegorz Cios, Stanislaw Cudzilo, Zbigniew Pedzich
Summary: This research presents the synthesis of B4C nanoparticles via vapor deposition and investigates their characteristics. The study evaluates the cytotoxicity effect of the synthesized nanoparticles on various cell lines, providing insights into their potential application in boron neutron capture therapy.
Article
Pharmacology & Pharmacy
Nina Dragicevic, Bojan Nikolic, Volker Albrecht, Alfred Fahr
Summary: Invasomes can enhance the skin penetration of mTHPC and deliver it to tumors, making them a potential option for topical PDT. The study also confirmed transdermal mTHPC delivery and suggested the possibility of using invasomes for diseases requiring systemic drug absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Yosuke Shimamura, Issei Takeuchi, Hiroshi Terada, Kimiko Makino
ANTICANCER RESEARCH
(2018)
Article
Oncology
Issei Takeuchi, Rina Mikuni, Kimiko Makino
ANTICANCER RESEARCH
(2018)
Article
Engineering, Biomedical
Issei Takeuchi, Yukari Hida, Kimiko Makino
BIO-MEDICAL MATERIALS AND ENGINEERING
(2018)
Article
Engineering, Biomedical
Issei Takeuchi, Haruhiko Onaka, Kimiko Makino
BIO-MEDICAL MATERIALS AND ENGINEERING
(2018)
Article
Chemistry, Physical
Issei Takeuchi, Yoshihiro Taniguchi, Yuki Tamura, Kazuhiro Ochiai, Kimiko Makino
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2018)
Article
Chemistry, Physical
Teruki Nii, Issei Takeuchi, Yukie Kimura, Kimiko Makino
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2018)
Article
Biophysics
Issei Takeuchi, Yuta Kamiki, Kimiko Makino
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Pharmacology & Pharmacy
Issei Takeuchi, Mako Otsuki, Hideki Kuroda, Kimiko Makino
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Chemistry, Medicinal
Takehisa Nakajima, Issei Takeuchi, Hiroyuki Ohshima, Hiroshi Terada, Kimiko Makino
JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Oncology
Yosuke Shimamura, Issei Takeuchi, Hiroshi Terada, Kimiko Makino
ANTICANCER RESEARCH
(2019)
Article
Biophysics
Issei Takeuchi, Yosuke Shimamura, Yuki Kakami, Tsunenori Kameda, Keitaro Hattori, Seiji Miura, Hiroyuki Shirai, Mutsuo Okumura, Toshio Inagi, Hiroshi Terada, Kimiko Makino
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Chemistry, Physical
Yuki Kakami, Issei Takeuchi, Kimiko Makino
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Biophysics
Issei Takeuchi, Kimiko Makino
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Chemistry, Applied
Issei Takeuchi, Mayu Anyama, Kimiko Makino
JOURNAL OF OLEO SCIENCE
(2019)