Review
Cell Biology
Yufeng Cheng, Ce Chen, Feng Zhang
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Multiple sclerosis, involve progressive loss of neuronal structure or function. The intestinal microbiome, as the second genome of the human body, is strongly implicated in the development of these diseases. However, the specific mechanisms by which the gut microbiota influences neurodegenerative diseases through the gut-brain axis and immune modulation are still not well understood.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Yimin Han, Boya Wang, Han Gao, Chengwei He, Rongxuan Hua, Chen Liang, Sitian Zhang, Ying Wang, Shuzi Xin, Jingdong Xu
Summary: The gut microbiota and the vagus nerve communicate bidirectionally and play important roles in maintaining homeostasis and various behaviors. However, there is inconsistency regarding their underlying mechanisms and clinical applications.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Food Science & Technology
Yueqin Li, Yao Peng, Yingbin Shen, Yunzhen Zhang, Lianliang Liu, Xinquan Yang
Summary: Advanced glycation end products (AGEs) are formed in the reaction between reducing sugars and amino acids, and play a key role in neurodegenerative diseases. Polyphenols with multiple hydroxyl groups can inhibit the formation of AGEs and prevent neurodegenerative diseases. Regulating gut microbiota and intestinal inflammation is also a strategy for preventing neurodegenerative diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Neurosciences
Yasir Bashir, Asad U. Khan
Summary: The gut microbiota may have an effect on the brain and potentially contribute to psychiatric and neurodegenerative diseases. However, more research is needed, particularly in human subjects, to fully understand and validate these findings.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Immunology
Yinwei Chen, Jinghua Zhou, Li Wang
Summary: The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Wei Wei, Shixu Wang, Chongchong Xu, Xuemei Zhou, Xinqing Lian, Lin He, Kuan Li
Summary: This review summarizes the possible mechanisms of NDs caused by abnormal accumulation of pathogenic proteins mediated by gut microbiota and explores the therapeutic potential of modulating gut microbiota in NDs.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Muruganantham Bharathi, Chaiyavat Chaiyasut
Summary: Parkinson's disease, a prevalent neurodegenerative disease, is influenced by the gut microbiota. Probiotic supplementation can improve symptoms and potentially serve as an adjunct therapy for Parkinson's disease. Further research on the role of probiotics in Parkinson's disease treatment is necessary.
Review
Agriculture, Dairy & Animal Science
Chaoyue Wen, Siyu Wei, Xin Zong, Yizhen Wang, Mingliang Jin
Summary: Heat stress has a negative impact on the gut microbiota and the gut-brain axis, disrupting the homeostasis between microbiota and the host. Therefore, appropriate nutritional strategies are crucial for alleviating intestinal heat stress.
Article
Nanoscience & Nanotechnology
Lei Qiao, Yue Chen, Xiaofan Song, Xina Dou, Chunlan Xu
Summary: The protective effects of Lactobacillus casei ATCC 393-SeNPs against AD were evaluated in a mouse model. The results showed that L. casei ATCC 393-SeNPs significantly improved cognitive function, reduced amyloid beta aggregation and hyperphosphorylation of TAU protein, and protected brain neurons from oxidative stress and neuroinflammation through multiple mechanisms.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nutrition & Dietetics
Yadong Zheng, Laura Bonfili, Tao Wei, Anna Maria Eleuteri
Summary: The gut-brain axis is a complex communication network between the gut and brain, involving neural, immune, and endocrine pathways. The gut microbiota plays an important role in this axis and its dysbiosis has been associated with neurodegenerative disorders. Manipulating the gut microbiota shows promise as a potential therapeutic target for these diseases.
Article
Biochemistry & Molecular Biology
Josune Garcia-Sanmartin, Miriam Bobadilla, Eduardo Mirpuri, Vanessa Grifoll, Margarita Perez-Clavijo, Alfredo Martinez
Summary: This study examined the protective effects of diets supplemented with 5% (w/w) of white button mushroom or Portobello mushroom against brain oxidative stress in mice. The results showed that these mushroom-supplemented diets significantly prevented neurodegenerative diseases caused by stress.
Review
Peripheral Vascular Disease
David L. Mattson, John Henry Dasinger, Justine M. Abais-Battad
Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.
Review
Nutrition & Dietetics
Yuan Zhang, Wanpeng Yu, Lei Zhang, Man Wang, Wenguang Chang
Summary: Polyphenols have potential effects in preventing and treating neurodegenerative diseases through their influence on the microbiota-gut-brain axis, promoting the production of beneficial metabolites by gut bacteria and exhibiting various physiological functions.
Review
Neurosciences
Piplu Bhuiyan, Yinan Chen, Mazharul Karim, Hongquan Dong, Yanning Qian
Summary: The global incidence of neurodegenerative diseases is on the rise with no effective therapeutic interventions available. Activation of immune cells in the central nervous system and subsequent neuroinflammation are characteristics of neurodegeneration. Bidirectional communication between mast cells and gut microbiota plays a key role in modulating neuroimmune responses, leading to neuroinflammatory processes associated with neurological disorders.
BRAIN RESEARCH BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Neurosciences
Javier Caballero-Villarraso, Francisco J. Medina, Begona M. Escribano, Eduardo Aguera, Abel Santamaria, Alvaro Pascual-Leone, Isaac Tunez
Summary: Transcranial Magnetic Stimulation (TMS) is a widely used tool in neurophysiology and has shown potential therapeutic effects for various psychiatric and neurodegenerative disorders. However, the molecular and physiological mechanisms underlying its beneficial effects are still unclear.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Article
Neurosciences
Begona M. Escribano, Ana Munoz-Jurado, Evelio Luque, Cristina Conde, Montse Feijoo, Manuel LaTorre, Manuel E. Valdelvira, Paula Buendia, Ana Giraldo, Javier Caballero-Villarraso, Abel Santamaria, Eduardo Aguera, Isaac Tunez
Summary: This study evaluated the effects of casein and lactose on Experimental Autoimmune Encephalomyelitis (EAE) and found that administration of casein and lactose improved the clinical status, reduced inflammation and oxidative stress, and had an impact on the glutathione redox system.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Article
Pathology
MDolores Carmona, Luis-Miguel Paco-Meza, Rosa Ortega, Sagrario Canadillas, Javier Caballero-Villarraso, Alfonso Blanco, Concha Herrera
Summary: This study demonstrated that hypoxia preconditioning enhances the ability of ASC from healthy rats to improve kidney injury in a rat model of diabetic nephropathy (DN). Interestingly, diabetic-derived ASC showed a similar ability to healthy ASC, but this effect was not significantly modified by hypoxia preconditioning.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Clinical Neurology
Begona Maria Escribano, A. Munoz-Jurado, J. Caballero-Villarraso, M. E. Valdelvira, A. Giraldo, E. Paz-Rojas, F. Gascon, A. Santamaria, E. Aguera, Isaac Tunez
Summary: This study found that melatonin supplementation in multiple sclerosis (MS) can benefit the clinical status of patients by reducing oxidative stress, inflammation, and bacterial dysbiosis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Sara Gomez-Melero, Fe Isabel Garcia-Maceira, Tania Garcia-Maceira, Veronica Luna-Guerrero, Gracia Montero-Penalvo, Javier Caballero-Villarraso, Isaac Tunez, Elier Paz-Rojas
Summary: A cell-based high-throughput calcium mobilization assay for CCR6 receptor has been successfully developed in this study. This assay is stable and reliable, showing dose-dependent response to the specific CCR6 ligand CCL20. It is suitable for high-throughput screening.
Article
Medicine, General & Internal
Javier Delgado-Lista, Juan F. Alcala-Diaz, Jose Torres-Pena, Gracia M. Quintana-Navarro, Francisco Fuentes, Antonio Garcia-Rios, Ana M. Ortiz-Morales, Ana Gonzalez-Requero, Ana Perez-Caballero, Elena M. Yubero-Serrano, Oriol A. Rangel-Zuniga, Antonio Camargo, Fernando Rodriguez-Cantalejo, Fernando Lopez-Segura, Lina Badimon, Jose M. Ordovas, Francisco Perez-Jimenez, Pablo Perez-Martinez, Jose Lopez-Miranda
Summary: The study compared the effects of Mediterranean diet and low-fat diet in the secondary prevention of cardiovascular disease, showing that the Mediterranean diet was superior in preventing major cardiovascular events.
Article
Medicine, General & Internal
Jose Verdu-Soriano, Marisol de Cristino-Espinar, Silvia Luna-Morales, Caridad Dios-Guerra, Javier Caballero-Villarraso, Paloma Moreno-Moreno, Antonio Casado-Diaz, Miriam Berenguer-Perez, Ipek Guler-Caamano, Olga Laosa-Zafra, Leocadio Rodriguez-Manas, Jose Luis Lazaro-Martinez
Summary: This 8-week clinical trial compared the novel Olea europaea leaf extract hydrogel (EHO-85) with a commonly used amorphous hydrogel in terms of accelerating wound healing. The results showed that EHO-85 significantly accelerated wound healing, doubling the median wound area reduction compared to the reference hydrogel.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
I. Tofe-Valera, J. L. Perez-Navero, J. Caballero-Villarraso, M. D. Canete, R. Villa-Jimenez, M. J. De la Torre-Aguilar
Summary: Preterm infants are at risk for vitamin D deficiency, but this study did not find any evidence of an increase in preterm birth risk related to vitamin D level at birth. Vitamin D deficiency itself is not associated with a higher incidence of comorbidities, but the combination of vitamin D and PTH levels should be taken into consideration.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Javier Villena-Salinas, Simeon Jose Ortega-Lozano, Tomader Amrani-Raissouni, Eduardo Aguera, Javier Caballero-Villarraso
Summary: The study aimed to evaluate the effectiveness of [I-123]Ioflupane SPECT in diagnosing MSA at the initial clinical suspicion. The results showed that SPECT had high sensitivity and positive predictive value, making it a useful tool for diagnosing MSA and distinguishing between subtypes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Gema Leon-Bravo, Irene Cantarero-Carmona, Javier Caballero-Villarraso
Summary: This study aims to investigate the prevalence of anomalous persistence of primitive reflexes (PRs) and craniosacral blocks (CBs) in healthy children and their impact on neurodevelopment and behavioral disorders. The results indicate that PRs and CBs are common in healthy children and are associated with disturbances in childhood neurodevelopment.
Review
Immunology
Sara Gomez-Melero, Javier Caballero-Villarraso
Summary: CCR6 is a GPCR involved in various biological processes. Its ligand CCL20 activates a signaling network important for diseases like cancer, psoriasis, multiple sclerosis, HIV infection, and rheumatoid arthritis. The CCR6/CCL20 axis plays a crucial role in immune homeostasis, inflammation, and cell recruitment to local tissues. Developing antibodies against CCR6 could be a promising alternative for small molecules in treating CCR6-related diseases.
Article
Neurosciences
Begona M. Escribano, Ana Munoz-Jurado, Evelio Luque, Alberto Galvan, Manuel Latorre, Javier Caballero-Villarraso, Ana I. Giraldo, Eduardo Aguera, Isaac Tunez
Summary: Stress is implicated in the pathological features of Multiple Sclerosis (MS). Various therapies have shown promise in reducing oxidative stress in an animal model of MS. This study aims to test the antioxidant effect of transcranial magnetic stimulation (TMS), extra virgin olive oil (EVOO), and S-allyl cysteine (SAC) and compare their efficacy. Combination therapies do not appear to be more effective than individual therapies.
Article
Biochemistry & Molecular Biology
Javier Villena-Salinas, Simeon Jose Ortega-Lozano, Tomader Amrani-Raissouni, Eduardo Aguera, Javier Caballero-Villarraso
Summary: Repeat SPECT at 12 months proves useful in the diagnosis and follow-up of MSA, showing significant changes in quantitative SPECT assessments. Repeated SPECT increases the diagnostic sensitivity and positive predictive value, and is decisive in the diagnosis of initial inconclusive cases.