Article
Agriculture, Dairy & Animal Science
Walid S. Habashy, Marie C. Milfort, Romdhane Rekaya, Samuel E. Aggrey
Summary: Performance traits and mortality of chickens are negatively impacted by heat stress, with the thioredoxin pathway system potentially offering clues for nutritional strategies to mitigate these effects.
Article
Immunology
Jinghai Yan, Shiguang Huang, Fangli Lu
Summary: The study revealed that blocking galectin-receptor interactions during acute Trichinella spiralis infection resulted in cardiac dysfunction, exacerbated heart pathology, and increased cardiac fibrosis. This was associated with elevated heart eosinophil recruitment and upregulation of Gal-3, which plays a pivotal role in heart functional damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuang Zheng, Jiaming Song, Dongli Linghu, Riyao Yang, Boning Liu, Zhen Xue, Qihui Chen, Chengjie Liu, Diansheng Zhong, Mien-Chie Hung, Linlin Sun
Summary: Gal-9 acts as an immunosuppressive regulator in the tumor microenvironment, and combination therapy targeting Gal-9 and ATM shows promising potential for cancer immunotherapy. Induction of Gal-9 via the STING/IFN β signaling pathway is an important mechanism mediating tumor immune escape.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun, Taeho Kwon
Summary: Our study investigated the role of Prx II in regulating exosome secretion from DMSCs and elucidated the underlying molecular mechanisms. We found that depletion of Prx II significantly decreased exosome secretion from DMSCs and increased the number of intracellular MVBs. Mechanistically, Prx II regulates the ISGylation switch that controls MVB degradation and impairs exosome secretion. These findings provide important insights into the molecular mechanisms governing exosome secretion from DMSCs and highlight the critical role of Prx II in controlling this process.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Jennifer L. Larson-Casey, Linlin Gu, Jungsoon Kang, Ashish Dhyani, A. Brent Carter
Summary: Pulmonary fibrosis is a progressive lung disease often caused by environmental exposure, with asbestos being a significant environmental mediator. Lung macrophages play a crucial role in generating ROS and promoting resistance to apoptosis, contributing to the pathogenesis of fibrosis. NOX4-mediated apoptosis resistance in monocyte-derived macrophages is suggested to be a potential therapeutic target for pulmonary fibrosis prevention and treatment.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Guoqi Li, Yihui Shao, Hong-Chang Guo, Ying Zhi, Bokang Qiao, Ke Ma, Jie Du, Yong-Qiang Lai, Yulin Li
Summary: miR-27b-3p induces pathological cardiac remodelling and inhibition of endogenous miR-27b-3p or administration of FGF1 might suppress cardiac remodelling.
CARDIOVASCULAR RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Linlin Gao, Zhenqiang Li, Wenxiao Chang, Yanyan Liu, Nan Zhang
Summary: The purpose of this study was to investigate the role of MYDGF in fibroblasts in periodontitis tissues induced by high glucose. The results showed that high glucose down-regulated the expression of MYDGF, leading to decreased cell viability, increased apoptosis and oxidative stress, as well as elevated expression of pro-inflammatory cytokines. However, overexpression of MYDGF reversed these effects.
JOURNAL OF DENTAL SCIENCES
(2023)
Review
Cell Biology
Rong Shen, Disheng Liu, Xiaoning Wang, Zhao Guo, Haonan Sun, Yanfeng Song, Degui Wang
Summary: DNA damage in tumorigenesis triggers strong inflammatory responses due to its immunogenicity, with the cGAS/STING pathway playing a crucial role in this process. Activation of the cGAS/STING pathway is essential for anti-tumor immunity, but may also be involved in tumor initiation and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Rong Shen, Disheng Liu, Xiaoning Wang, Zhao Guo, Haonan Sun, Yanfeng Song, Degui Wang
Summary: DNA damage plays a crucial role in tumorigenesis and development, and the cGAS/STING pathway is a key player in immune response. Recent studies have highlighted its significance in tumor immunotherapy and initiation/metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zhicheng Hu, Peng Chen, Linlin Wang, Yu Zhu, Gen Chen, Yunjie Chen, Zhenyu Hu, Lin Mei, Weijing You, Weitao Cong, Litai Jin, Xu Wang, Yang Wang, Xueqiang Guan
Summary: This study investigated the role of fibroblast growth factor 6 (FGF6) in enhancing the proliferative potential of cardiomyocytes (CMs) after ischemic injury via the Hippo pathway. The results showed that FGF6 expression was significantly increased in the myocardial infarction (MI) mouse model. Treatment with recombinant human FGF6 protein improved heart function, reduced infarct size, and promoted cardiac repair. FGF6 was found to inhibit the Hippo pathway via ERK1/2, and facilitate nuclear translocation of YAP, thereby promoting cardiac repair after MI.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Fenghong Wang, Qingqing Liang, Yuexiao Ma, Mengqi Sun, Tianyu Li, Lisen Lin, Zhiwei Sun, Junchao Duan
Summary: Exposure to SiNPs may lead to cardiac hypertrophy and pyroptosis, possibly through the ROS/NLRP3/Caspase-1 signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Reproductive Biology
Jinling Wang, Lei Wang, Zhiqiang Wang, Meiyun Lv, Jiayuan Fu, Yunchuan Zhang, Peng Qiu, Deshun Shi, Chan Luo
Summary: The success of reprogramming depends on the reprogramming factors in recipient oocytes and the reprogrammability of donor nuclei. Histone 3 lysine 9 trimethylation (H3K9me3) is a major epigenetic barrier to reprogramming. Vitamin C (Vc) treatment can enhance the development potential of cloned embryos. This study reveals that Vc can down-regulate H3K9me3-dependent heterochromatin in BFFs through the PI3K/PDK1/SGK1/KDM4A signaling pathway.
Article
Biochemistry & Molecular Biology
Jian Yang, Ying Liu, Shengnan Lu, Xuejia Sun, Yue Yin, Kaifeng Wang, Shi Liu
Summary: This study investigated the mechanism of Coix seed oil (CSO) induction of pancreatic cancer cell apoptosis. The results showed that CSO induces apoptosis of PANC-1 pancreatic cancer cells by modulating mitochondrial functional impairment and related apoptotic molecules via PTEN, which may be closely related to the PI3K/AKT signaling pathway.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Immunology
Marta De Angelis, Donatella Amatore, Paola Checconi, Alessandra Zevini, Alessandra Fraternale, Mauro Magnani, John Hiscott, Giovanna De Chiara, Anna Teresa Palamara, Lucia Nencioni
Summary: Influenza virus infection reduces G6PD expression and activity, leading to increased oxidative stress and virus replication. Modulation of G6PD during viral infection may affect redox homeostasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jemima Seidenberg, Mara Stellato, Amela Hukara, Burkhard Ludewig, Karin Klingel, Oliver Distler, Przemyslaw Blyszczuk, Gabriela Kania
Summary: The study reveals that Fosl-2 regulates autophagy, while the TGF-beta-Fosl-2-autophagy axis controls the differentiation of cardiac fibroblasts. Experimental validation of this mechanism was conducted and confirmed in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Emergency Medicine
Javier Arredondo Montero, Carlos Bardaji Pascual, Giuseppa Antona, Monica Bronte Anaut, Natalia Lopez-Andres, Nerea Martin-Calvo
Summary: The study examined the diagnostic performance of serum, fecal and urinary calprotectin, as well as the APPY-1 biomarker panel in pediatric acute appendicitis. Serum calprotectin showed limited diagnostic yield, while APPY-1 test was reliable in excluding the diagnosis of AA in patients at low or moderate risk.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Barbara C. S. Hamilton, Dang Nguyen, Sean C. Grondin, Patrick O. Myers, Carolyn M. Young, John H. Calhoon, Marc R. Moon, Yolonda L. Colson, Shaf Keshavjee, Tom C. Nguyen
Summary: This study examines the cardiothoracic surgery community by analyzing the membership directories of four major societies. The study reveals a low proportion of female members and a median age of 57 years. The majority of members specialize in adult cardiac surgery. The study emphasizes the need to address the concerns and take action to promote diversity and attract trainees in the field.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Walter J. Gomes, Victor Dayan, Patrick O. Myers, Rui Almeida, John D. Puskas, David P. Taggart, Hirokuni Arai, Minoru Ono, Yutaka Okita, Om P. Yadava, Ki-Bong Kim, Zhe Zheng, Jorge Rodriguez-Roda, Alessandro Parolari, Miguel Sousa Uva, J. Rafael Sadaba
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Biographical-Item
Cardiac & Cardiovascular Systems
Mario Gaudino, Nick Freemantle, Rafael Sadaba
EUROPEAN HEART JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Sara Badesso, Paz Cartas-Cejudo, Maria Espelosin, Enrique Santamaria, Mar Cuadrado-Tejedor, Ana Garcia-Osta
Summary: DHA, as the most abundant polyunsaturated fatty acid in the brain, is essential for successful aging and may lower the risk for developing Alzheimer's disease. DHA enhances memory function through promoting synapse formation and has potential for dietary supplement for AD dementia prevention.
Review
Medicine, General & Internal
Fabio Barili, James M. Brophy, Daniele Ronco, Patrick O. Myers, Miguel Sousa Uva, Rui M. S. Almeida, Mateo Marin-Cuartas, Amedeo Anselmi, Jacques Tomasi, Jean-Philippe Verhoye, Francesco Musumeci, John Mandrola, Sanjay Kaul, Stefania Papatheodorou, Alessandro Parolari
Summary: This study highlights significant biases in randomized clinical trials comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR), including nonrandom allocation, loss to follow-up, and additional procedures, which may impact internal validity.
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Qing Lu, Jaime Ibarrola, Alec Stepanian, Joshua J. Man, Brigett V. Carvajal, Nicholas D. Camarda, Zsuzsanna Zsengeller, Geraldine Skurnik, Ellen W. Seely, S. Ananth Karumanchi, Iris Z. Jaffe
Summary: Preeclampsia is associated with hypertension and end organ damage, and women exposed to preeclampsia have an increased risk of hypertension after pregnancy. This study found that exposure to sFlt1 during pregnancy leads to enhanced responsiveness of smooth muscle cell mineralocorticoid receptors (SMC-MR) to hypertensive stimuli, contributing to postpartum hypertension. These findings suggest that targeting SMC-MR could be a potential intervention to mitigate cardiovascular risk in women after preeclampsia.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Nayra Felipez, Sheyla Montori, Naroa Mendizuri, Joan Llach, Pedro G. G. Delgado, Leticia Moreira, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Eduardo Albeniz
Summary: Gastric cancer is a global public health problem with high mortality rates. Biomarker research is crucial for early detection of gastric cancer. Technological advances have identified several potential biomarkers, but their low specificity in biofluids limits their clinical use. Recent research focuses on exploring gastric juice as an alternative source for biomarker identification, as it contains disease-specific biomarkers generated at the site of damage. This narrative review describes potential biomarkers for gastric cancer screening in gastric juice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pol Andres-Benito, Africa Flores, Sara Busquet-Areny, Margarita Carmona, Karina Ausin, Paz Cartas-Cejudo, Mercedes Lachen-Montes, Jose Antonio Del Rio, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Isidro Ferrer
Summary: Transcriptomics and phosphoproteomics analyses revealed altered gene expression and phosphorylation levels in the cerebral cortex of tau knockout mice. Tau knockout mice exhibited reduced anxiety-like behavior and fear expression, while recognition memory remained unchanged. The altered gene expression affected synaptic structures, neuron cytoskeleton, transport, and extracellular matrix components, while the deregulated phosphorylation levels impacted cytoskeletal and membrane proteins, DNA and RNA metabolism, and various signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Sigrid Sandner, Martin Misfeld, Etem Caliskan, Andreas Boening, Jose P. Aramendi, Sacha Salzberg, Yeong-Hoon P. Choi, Louis Perrault, Ilker P. Tekin, Gregorio Cuerpo, Jose P. Lopez-Menendez, Luca Weltert, Johannes Boehm, Markus Krane, Jose M. Gonzalez-Santos, Juan-Carlos Tellez, Tomas Holubec, Enrico Ferrari, Gheorghe J. Doros, Clara Y. Vitarello, Maximilian Emmert
Summary: The objective of this study was to evaluate the clinical outcomes and quality of life of patients undergoing coronary artery bypass grafting (CABG) using an endothelial damage inhibitor (DuraGraft). The results showed that over time, the clinical event rate of patients decreased and their quality of life improved.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lidia Puertas-Umbert, Saray Varona, Carme Ballester-Servera, Judith Alonso, Silvia Aguilo, Mar Orriols, Ernesto Martinez-Martinez, Antonio Rodriguez-Sinovas, Jose Martinez-Gonzalez, Cristina Rodriguez
Article
Cardiac & Cardiovascular Systems
Yen-Chun Ho, Xin Geng, Anna O'Donnell, Jaime Ibarrola, Amaya Fernandez-Celis, Rohan Varshney, Kumar Subramani, Zheila J. Azartash-Namin, Jang Kim, Robert Silasi, Jill Wylie-Sears, Zahra Alvandi, Lijuan Chen, Boksik Cha, Hong Chen, Lijun Xia, Bin Zhou, Florea Lupu, Harold M. Burkhart, Elena Aikawa, Lorin E. Olson, Jasimuddin Ahamed, Natalia Lopez-Andres, Joyce Bischoff, Katherine E. Yutzey, R. Sathish Srinivasan
Summary: PROX1 and FOXC2 are involved in the development and disease of cardiac valves. Deletion of PROX1 leads to thickening and myxomatous degeneration of valves, while abnormal expression of FOXC2 and PDGF-B is related to valve prolapse and valve insufficiency. Pharmacological inhibition of PDGF-B signaling can partially correct valve defects.
CIRCULATION RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Colin Baigent, Rafael Sadaba
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Lara Matilla, Ernesto Martin-Nunez, Mattie Garaikoetxea, Adela Navarro, Ibai Tamayo, Amaya Fernandez-Celis, Alicia Gainza, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Pieter Muntendam, Virginia Alvarez, Rafael Sadaba, Eva Jover, Natalia Lopez-Andres
Summary: Gal-3 expression in aortic valves (AVs) and valve interstitial cells (VICs) is significantly higher in male patients with AS compared to females with the same severity of AS. Gal-3 is mainly expressed by activated VICs and endothelial cells in men, while in women it is mainly expressed by quiescent VICs and endothelial cells. Gal-3 is directly associated with pathological features of AS in a sex-differential way, suggesting a potential new sex-specific therapeutic target for AS.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jamie A. Mawhinney, Craig A. Mounsey, Alastair O'Brien, J. Rafael Sadaba, Nick Freemantle
Summary: This article demonstrates some major issues with risk scores by using "Strictly Come Dancing" as an example.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)