Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans
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Title
Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans
Authors
Keywords
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Journal
CLINICAL PHARMACOKINETICS
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-05-26
DOI
10.1007/s40262-018-0680-3
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- (2017) Christophe Passot et al. THERAPEUTIC DRUG MONITORING
- Immunoassays for Measuring Serum Concentrations of Monoclonal Antibodies and Anti-biopharmaceutical Antibodies in Patients
- (2017) François Darrouzain et al. THERAPEUTIC DRUG MONITORING
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- (2017) Liming Liu Protein & Cell
- Use of a Target-Mediated Drug Disposition Model to Predict the Human Pharmacokinetics and Target Occupancy of GC1118, an Anti-epidermal Growth Factor Receptor Antibody
- (2016) Wan-Su Park et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation
- (2016) Sonata Jodele et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
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- (2016) E. Niclas Jonsson et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Gerald R. Galluppi et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Guillemette Bernadou et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Bo Zheng et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- A method for optimizing dosage regimens in oncology by visualizing the safety and efficacy response surface: analysis of inotuzumab ozogamicin
- (2016) Kenneth T. Luu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Population pharmacokinetics of bevacizumab in cancer patients with external validation
- (2016) Kelong Han et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2016) Katherine L. Gill et al. CLINICAL PHARMACOKINETICS
- Bevacizumab Pharmacokinetics Influence Overall and Progression-Free Survival in Metastatic Colorectal Cancer Patients
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- (2016) Tian Yu et al. CLINICAL PHARMACOKINETICS
- Population Pharmacokinetics of Necitumumab in Cancer Patients
- (2016) Amanda Long et al. CLINICAL PHARMACOKINETICS
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- (2016) Wataru Honma et al. Drug Metabolism and Pharmacokinetics
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- (2016) John P. Gibbs et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Haiying Sun et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) N.M. Mostafa et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
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- (2016) Christophe Passot et al. mAbs
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- (2007) David Ternant et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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