Article
Pharmacology & Pharmacy
Eugenia Santacana Juncosa, Lorena Rodriguez-Alonso, Ariadna Padulles Zamora, Jordi Guardiola, Francisco Rodriguez-Moranta, Katja Serra Nilsson, Jordi Bas Minguet, Francisco Morandeira Rego, Helena Colom Codina, Nuria Padulles Zamora
Summary: Therapeutic drug monitoring of infliximab combined with Bayesian forecasting methodology can effectively improve clinical responses in patients with inflammatory bowel disease. Optimized dosing of infliximab through this approach helps increase remission rates and overall treatment efficacy for these patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Christina Schraepel, Lukas Kovar, Dominik Selzer, Ute Hofmann, Florian Tran, Walter Reinisch, Matthias Schwab, Thorsten Lehr
Summary: The study evaluated the predictive performance of published infliximab population pharmacokinetic models for IBD patients with an external dataset, finding that for patients without anti-drug antibodies, the accuracy of predictions decreased after 6 months, while predictions for ADA-developing patients were inaccurate across all models. Two models with high classification accuracy were able to identify necessary dose escalations in 88% of cases.
Article
Pharmacology & Pharmacy
Celine Konecki, Catherine Feliu, Yoann Cazaubon, Delphine Giusti, Marcelle Tonye-Libyh, Hedia Brixi, Guillaume Cadiot, Amelie Biron, Zoubir Djerada
Summary: This study evaluated eight pharmacokinetic models of infliximab for external validation, showing significant performance variations among the models. Models A and B demonstrated satisfactory results, while highlighting potential areas for improvement.
Article
Gastroenterology & Hepatology
Anne S. Strik, Mark Lowenberg, Diane R. Mould, Sophie E. Berends, Cyriel Ponsioen, Jan M. H. van den Brande, Jeroen M. Jansen, Daniel R. Hoekman, Johannan F. Brandse, Marjolijn Duijvestein, Krisztina B. Gecse, Annick de Vries, Ron A. Mathot, Geert R. D'Haens
Summary: In IBD patients, using a Bayesian dashboard for IFX dosing can reduce the incidence of LOR and lower fecal calprotectin levels. Additionally, this method can increase the proportion of patients in sustained clinical remission.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Claire Liefferinckx, Jeremie Bottieau, Jean-Francois Toubeau, Debby Thomas, Jean-Francois Rahier, Edouard Louis, Filip Baert, Pieter Dewint, Lieven Pouillon, Guy Lambrecht, Francois Vallee, Severine Vermeire, Peter Bossuyt, Denis Franchimont
Summary: This study demonstrated the clinical relevance of measuring new infliximab levels during induction to predict remission in patients with inflammatory bowel disease (IBD). These findings lay the foundation for early monitoring of biotherapies and improvement in patients' clinical management.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Sung Noh Hong, Joo Hye Song, Sung Jin Kim, Yoon Ha Park, Chang Wan Choi, Ji Eun Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim
Summary: This study aimed to evaluate the long-term clinical outcomes of patients with inflammatory bowel disease (IBD) treated with subcutaneous infliximab (IFX) compared to intravenous IFX during maintenance therapy. The results showed that the subcutaneous IFX group had a higher one-year durable remission rate than the intravenous IFX group, with similar safety.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
Stefano Bruscoli, Marta Febo, Carlo Riccardi, Graziella Migliorati
Summary: Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease (CD) and involves immune cell alteration and chronic inflammatory cascade activation against unknown environmental triggers. Therapy focuses on supporting measures and use of anti-inflammatory and immunosuppressive drugs, with glucocorticoids (GCs) being a cornerstone treatment for moderate-to-severe IBD. However, their use is limited by important adverse drug effects, leading researchers to explore newer, safer alternatives.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wannee Kantasiripitak, An Outtier, Sebastian G. Wicha, Alexander Kensert, Zhigang Wang, Joao Sabino, Severine Vermeire, Debby Thomas, Marc Ferrante, Erwin Dreesen
Summary: In patients with inflammatory bowel diseases, using a model averaging algorithm based on maximum a posteriori prediction shows better predictive performance for Infliximab dosage de-escalation compared to a model selection algorithm or a single-model approach. Only a single trough concentration is necessary for accurate and precise prediction, and the predictive performance is robust to the lack of covariate data.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ana-Marija Grisic, Maria Dorn-Rasmussen, Bella Ungar, Jorn Brynskov, Johan F. K. F. Ilvemark, Nils Bolstad, David J. Warren, Mark A. Ainsworth, Wilhelm Huisinga, Shomron Ben-Horin, Charlotte Kloft, Casper Steenholdt
Summary: Infliximab clearance decreases significantly in the second and third trimesters of pregnancy, leading to increasing maternal infliximab concentrations in any given regimen. Maternal infliximab levels may be maintained as constant in a de-intensified regimen by therapeutic drug monitoring guidance in inflammatory bowel disease.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Chemistry, Medicinal
Xin Liu, Gehang Ju, Wenyu Yang, Lulu Chen, Nuo Xu, Qingfeng He, Xiao Zhu, Dongsheng Ouyang
Summary: Escitalopram (SCIT) is a widely used antidepressant and antianxiety medication with significant interindividual variability in pharmacokinetics. This study aimed to establish a parametric population pharmacokinetic (PPK) model of SCIT for personalized dosing. The impact of covariates on clearance, including CYP2C19 phenotype, weight, and age, was evaluated. It was found that dosing regimens should be tailored based on these factors. Furthermore, the exposure to SCIT among Chinese psychiatric patients was significantly higher compared to other populations, indicating a need for further investigation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Gastroenterology & Hepatology
Hiroshi Nakase, Motoi Uchino, Shinichiro Shinzaki, Minoru Matsuura, Katsuyoshi Matsuoka, Taku Kobayashi, Masayuki Saruta, Fumihito Hirai, Keisuke Hata, Sakiko Hiraoka, Motohiro Esaki, Ken Sugimoto, Toshimitsu Fuji, Kenji Watanabe, Shiro Nakamura, Nagamu Inoue, Toshiyuki Itoh, Makoto Naganuma, Tadakazu Hisamatsu, Mamoru Watanabe, Hiroto Miwa, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike
Summary: Inflammatory bowel disease (IBD) encompasses chronic or remitting/relapsing inflammatory diseases of the intestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD). The etiology of IBD involves disease susceptibility genes, environmental factors, and intestinal bacteria. Optimal management depends on evidence-based interventions tailored by physicians.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Xavier Roblin, Stephane Nancey, Konstantinos Papamichael, Gerard Duru, Mathurin Flamand, Sandy Kwiatek, Adam Cheifetz, Nicole Fabien, Mathilde Barrau, Stephane Paul
Summary: Higher concentrations of subcutaneous infliximab are associated with better therapeutic outcomes in patients with inflammatory bowel disease, especially deep remission.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Materials Science, Biomaterials
Yeli Fan, Xinyu Wang, Ge Yan, Hongfang Gao, Min Yang
Summary: Inflammatory bowel diseases (IBDs) are chronic gastrointestinal inflammation, and the pro-inflammatory cytokine TNF-α plays a key role in its pathogenesis. We developed polyphenol-poloxamer nanoparticles loaded with anti-inflammatory INF as a novel IBD therapy, which can be administered rectally for localized drug delivery, prolonging drug activity and minimizing systemic exposure, showing high therapeutic potential.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Stefano Fogli, Sara Galimberti, Veronica Gori, Marzia Del Re, Romano Danesi
Summary: This review article explores the differences in potency, selectivity, pharmacokinetics, safety, and drug-drug interactions of clinically validated proteasome inhibitors, aiming to provide useful information for their clinical use in real life settings.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Infectious Diseases
Patrick O. Hanafin, Andrea Kwa, Alexandre P. Zavascki, Ana Maria Sandri, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P. Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Jason M. Pogue, Anthony W. Purcell, Roger L. Nation, Jian Li, Keith S. Kaye, Gauri G. Rao
Summary: This study developed a population pharmacokinetic model for hospitalized patients receiving polymyxin B, finding factors that may require dose adjustments when using this drug. Substantial variability in drug clearance and distribution was observed, suggesting the need for therapeutic drug monitoring.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Gastroenterology & Hepatology
Tessa Straatmijer, Vince B. C. Biemans, Marijn Visschedijk, Frank Hoentjen, Annemarie de Vries, Adriaan A. van Bodegraven, Alexander Bodelier, Nanne K. H. de Boer, Gerard Dijkstra, Noortje Festen, Carmen Horjus, Jeroen M. Jansen, Bindia Jharap, Wout Mares, Fiona D. M. van Schaik, Cyriel Ponsioen, Tessa Romkens, Nidhi Srivastava, Michael M. P. J. A. van der Voorn, Rachel West, Janneke van der Woude, Marije D. J. Wolvers, Marieke Pierik, Andrea E. van der Meulen-de Jong, Marjolijn Duijvestein
Summary: This study compared the effectiveness and safety of vedolizumab and tofacitinib in anti-TNF-exposed patients with UC. The results showed that tofacitinib was associated with superior effectiveness outcomes compared with vedolizumab, along with comparable safety outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Liu, Mehdi Sadaghian Sadabad, Giorgio Gabarrini, Paola Lisotto, Julius Z. H. von Martels, Hannah R. R. Wardill, Gerard Dijkstra, Robert E. Steinert, Hermie J. M. Harmsen
Summary: This study investigated the effects of riboflavin supplementation on gut microbiota, short-chain fatty acids, and gut hormones. The results revealed an increase in butyrate production and enhancement of microbial interaction network after riboflavin intervention. However, riboflavin supplementation did not impact the abundance of F. prausnitzii. Additionally, supplementation with 100 mg/d of riboflavin showed a trend of increased plasma insulin and GLP-1 levels.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Tessa Straatmijer, Fiona D. M. van Schaik, Alexander G. L. Bodelier, Marijn Visschedijk, Annemarie C. de Vries, Cyriel Y. Ponsioen, Marieke Pierik, Ad A. van Bodegraven, Rachel L. West, Nanne K. H. de Boer, Nidhi Srivastava, Tessa E. H. Romkens, Jildou Hoekstra, Bas Oldenburg, Gerard Dijkstra, Janneke C. van der Woude, Mark Lowenberg, Zlatan Mujagic, Vince B. C. Biemans, Andrea E. Van der Meulen-de Jong, Marjolijn Duijvestein
Summary: The aim of this study was to evaluate the effectiveness and safety of 24 months of tofacitinib use in patients with ulcerative colitis in the Netherlands. The results showed that 31.8% of patients achieved corticosteroid-free clinical remission after 24 months of tofacitinib treatment. The main side effects were skin reactions and headaches.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jeanine H. C. Arkenbosch, Evelien M. J. Beelen, Gerard Dijkstra, Marielle Romberg-Camps, Marjolijn Duijvestein, Frank Hoentjen, Sander van der Marel, P. W. Jeroen Maljaars, Sita Jansen, Nanne K. H. de Boer, Rachel L. West, Carmen S. Horjus, Laurents P. S. Stassen, Fiona D. M. van Schaik, Oddeke van Ruler, Bindia J. H. Jharap, Marijn Visschedijk, Alfred Janssen, Nicole S. Erler, Michail Doukas, Ariadne H. A. G. Ooms, Gursah Kats-Ugurlu, C. Janneke van der Woude, Annemarie C. de Vries
Summary: This study aimed to evaluate the effectiveness of a clinical management algorithm in preventing recurrence after ileocolonic resection in Crohn's disease and determine the predictive value of clinical and histological risk factors. The results showed that prophylactic medication can effectively reduce endoscopic recurrence in both low-risk and high-risk patients. Clinical risk stratification has a certain predictive value in predicting patient recurrence but further improvements are needed.
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Gastroenterology & Hepatology
Sem Geertsema, Harry van Goor, Gerard Dijkstra, Klaas Nico Faber, Arno R. Bourgonje
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Gastroenterology & Hepatology
Adrianus. M. van Der Holst, Antonius T. Otten, Elise M. Meima-van Praag, Alexander R. P. K. M. van Renterghem, Arno R. Bourgonje, Ellen S. van Loo, Gerard Dijkstra, Christianne J. Buskens, Laurents P. S. Stassen
Summary: Creation of a diverting stoma in patients with Crohn's disease may counteract luminal inflammation. This study aimed to evaluate the long-term effects of a diverting stoma on the disease course. Findings suggest that a diverting stoma could be an alternative in specific populations of patients with luminal colonic CD, especially in the absence of proctitis.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Roberta Loveikyte, Arno R. Bourgonje, Johannes J. van der Reijden, Marian L. C. Bulthuis, Lukas J. A. C. Hawinkels, Marijn C. Visschedijk, Eleonora A. M. Festen, Hendrik M. van Dullemen, Rinse K. Weersma, Harry van Goor, Andrea E. van der Meulen-de Jong, Gerard Dijkstra
Summary: Absolute iron deficiency is the main factor determining hepcidin levels, even in an inflammatory state. Induction therapy can decrease hepcidin levels, which may improve the availability of iron. Therefore, hepcidin is a potential diagnostic biomarker for iron deficiency and can assist in therapeutic decision making.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Antonius T. Otten, Hedwig H. van der Meulen, Maurice Steenhuis, Floris C. Loeff, Daan J. Touw, Jos G. W. Kosterink, Henderik W. Frijlink, Theo Rispens, Gerard Dijkstra, Marijn C. Visschedijk, Arno R. Bourgonje
Summary: A finger prick-based capillary blood self-sampling technique was validated for monitoring infliximab, vedolizumab, and C-reactive protein concentrations in patients with inflammatory bowel disease. The technique received substantial support from patients and demonstrated good tolerability and practicality.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Antonius Timotheus Otten, V Peters, I Barth, C. L. Stevens, A. R. Bourgonje, H. W. Frijlink, H. J. M. Harmsen, A. Rehman, M. J. E. Campmans-Kuijpers, G. Dijkstra
Summary: This article describes a nutritional intervention trial on patients with Crohn's disease (CD) and their healthy household members, investigating the effects of an evidence-based anti-inflammatory diet and an ileocolonic-targeted capsule containing vitamin B2, B3, and C. The results of the study will provide valuable evidence for dietary recommendations for CD patients and physicians.
Article
Pharmacology & Pharmacy
Aisha A. Ahmed, Antonius T. Otten, Bahez Gareb, Judith E. Huijmans, Anko C. Eissens, Ateequr Rehman, Gerard Dijkstra, Jos G. W. Kosterink, Henderik W. Frijlink, Reinout C. A. Schellekens
Summary: The development of capsules containing riboflavin, nicotinic acid, and ascorbic acid covered with a pH-sensitive coating (ColoVit) was described to achieve site-specific release in the ileocolon. The capsules met the required specifications and had a lag-time in drug release of 277-283 min, which meets the requirements for ileocolonic release. The production process of the ColoVit formulation was validated and reproducible, and the vitamin blend was stable during the production process and in the finished coated product. ColoVit is intended as an innovative treatment approach for beneficial microbiome modulation and optimization of gut health.
Letter
Gastroenterology & Hepatology
Antonius T. Otten, Gerard Dijkstra, Marijn C. Visschedijk, Arno R. Bourgonje
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Sem Geertsema, Arno R. Bourgonje, Raphael R. Fagundes, Ranko Gacesa, Rinse K. Weersma, Harry van Goor, Giovanni E. Mann, Gerard Dijkstra, Klaas N. Faber
Summary: Oxidative stress is an important mechanism in inflammatory bowel disease. The NRF2/Keap1 pathway regulates cellular responses to oxidative stress and has been implicated in the development of inflammatory bowel disease. Activation of the NRF2/Keap1 pathway enhances antioxidant responses and may potentially improve clinical outcomes for inflammatory bowel disease.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Immunology
Yuchen Yang, Li Wang, Ivonne Peugnet-Gonzalez, Daniela Parada-Venegas, Gerard Dijkstra, Klaas Nico Faber
Summary: The intestinal mucosa serves as a barrier and is involved in nutrient absorption. Genetic susceptibility and environmental factors play a critical role in the development of intestinal diseases. The innate immune system recognizes potential threats through pattern recognition receptors (PRRs), including the cGAS-STING pathway. However, the role of the cGAS-STING pathway in intestinal diseases is still debated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)