Review
Gastroenterology & Hepatology
Puneeta Tandon, Anne Walling, Heather Patton, Tamar Taddei
Summary: Palliative Care is an approach focusing on improving the quality of life for patients facing life-limiting illness, applicable in cirrhosis patients. However, there is limited guidance and promotion of PC in patients with cirrhosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
A. Bosco, C. Di Lorito, M. Dunlop, A. Booth, D. Alexander, S. Jones, B. R. Underwood, C. Todd, A. Burns
Summary: This study explores the views of hospice dementia care for bereaved carers of people with dementia and hospice clinicians. The results indicate that rapid response teams delivering hospice home care could be a better option, and may require joined-up care with other community services.
Article
Surgery
Joanna Wycech, Alexander A. Fokin, Jeffrey K. Katz, Sari Viitaniemi, Nicholas Menzione, Ivan Puente
Summary: Palliative care consultations for trauma patients showed differences between geriatric and non-geriatric patients. Non-geriatric patients had more severe injuries, received more aggressive treatment, but had longer time to palliative care consultations and a higher rate of futile interventions compared to geriatrics.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Takaaki Kobayashi, Jorge L. Salinas, Patrick Ten Eyck, Benjamin Chen, Tomo Ando, Kengo Inagaki, Mohammed Alsuhaibani, Paul G. Auwaerter, Ilonka Molano, Daniel J. Diekema
Summary: Palliative care consultation is not commonly utilized in Staphylococcus aureus bacteremia patients in the United States, despite potential benefits. Factors associated with palliative care consult include older age, white race, comorbidities, higher income, hospital characteristics, region, and disease severity. Patients who received palliative care consult had shorter hospital stays but higher mortality rates compared to those who did not receive consultation.
PALLIATIVE MEDICINE
(2021)
Article
Oncology
Yong Liu, Yin Shen, Qinghua Pan, Huasheng He, Houwen Zou, Zuochao Huang, Zhiping Liu, Xiaomao Wang
Summary: This study aimed to investigate the effectiveness of interdisciplinary collaborative hospice care (ICHC) on terminal geriatric cancer patients (TGCP) and compare it with life-sustaining treatment (LST) in terms of emotional function, symptom improvement, and cost. The results showed that ICHC had better treatment outcomes, lower medication costs, and higher patient satisfaction.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Pediatrics
Khaliah A. Johnson, Alexis Morvant, Kristin James, Lisa C. Lindley
Summary: The passage discusses the significance of the Concurrent Care for Children Provision of the Affordable Care Act and how its implementation varies across states. It also emphasizes the importance of collaboration with Medicaid programs in improving the quality of pediatric care.
Article
Geriatrics & Gerontology
Deven Lackraj, Dio Kavalieratos, Komal P. Murali, Yewei Lu, May Hua
Summary: Implementing a specialist palliative care program was associated with an increased likelihood of discharging patients with dementia to hospice following acute hospitalization, with no significant impact on secondary outcomes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Multidisciplinary Sciences
Lin Chen, Xiao-Hong Li, Xiao Pan, Qi-Ni Pan, Hui-Qiao Huang, Pin-Yue Tao, Gao-Ye Li, Jin-Hui Ma, Jing-Can Huang
Summary: This study found a knowledge gap and moderate attitudes toward hospice care among nurses, and most nurses did not prefer to practice hospice care. Having been trained in hospice care was the main common factor of nurses' knowledge of, attitudes toward, and willingness to practice hospice care in the future, indicating the necessity to provide nurses with more targeted hospice care training.
Article
Urology & Nephrology
Manjula Kurella Tamura, Laura Holdsworth, Margaret Stedman, Annette Aldous, Steven M. Asch, Jialin Han, Glenda Harbert, Karl A. Lorenz, Elizabeth Malcolm, Amanda Nicklas, Alvin H. Moss, Dale E. Lupu
Summary: This study aims to investigate whether a learning collaborative can improve the delivery of palliative care best practices in hemodialysis centers. The results show that participation in the learning collaborative was associated with a significant increase in the probability of complete advance care planning documentation among seriously ill patients.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Clark DuMontier, Hajime Uno, Tammy Hshieh, Guohai Zhou, Richard Chen, Emily S. Magnavita, Lee Mozessohn, Houman Javedan, Richard M. Stone, Robert J. Soiffer, Jane A. Driver, Gregory A. Abel
Summary: This study examined the impact of geriatrician consultation on older adults with hematologic malignancies and found that consultation did not improve survival rates but increased the likelihood of end-of-life goals-of-care discussions.
Article
Health Care Sciences & Services
Debra Lotstein, Margaret J. Klein, Lisa C. Lindley, Joanne Wolfe
Summary: This study investigated the referral practices of a hospital-based pediatric palliative care team to community-based programs. It found that only a minority of patients received referrals, and those in the ICU and with neurologic conditions may be at higher risk of missing appropriate referrals.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Nursing
Linda Heino, Minna Stolt, Elina Haavisto
Summary: This study describes the practices of nurses regarding palliative sedation in palliative care wards in hospitals. The findings indicate that nurses play a crucial role in decision-making, implementation and monitoring of sedation, as well as in information sharing and providing compassionate care to patients and their relatives.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Nursing
Kyung-Ah Kang, Jiyoung Chun, Hyun Yong Kim, Hyeon-Young Kim
Summary: The study indicates that understanding and providing spiritual care is essential for nurses, but many lack a clear understanding, highlighting the need for enhanced training and education in spiritual care competence.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Oncology
Li Mo, Diana L. Urbauer, Eduardo Bruera, David Hui
Summary: The study found that specialist palliative care is integral in oncologic care and its integration into NCCN guidelines varies. Palliative care is mentioned more frequently in solid tumor guidelines than hematologic, and there is a lack of discussion on palliative care in hematologic malignancy guidelines. Improving standardization of timely palliative care access across NCCN guidelines is crucial.
Review
Health Care Sciences & Services
Jessica Geiger, Gavin Enck, Lisa Luciani, Jeffrey Fudin, Mary Lynn McPherson
Summary: This article provides an overview of pharmacists' involvement with palliative care, highlighting their integral role on the team. It points out the lack of board certification in palliative care for pharmacists despite their years of participation on multidisciplinary teams.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Multidisciplinary Sciences
Jyh-Ming Jimmy Juang, Tzu-Pin Lu, Ming-Wei Su, Chien-Wei Lin, Jenn-Hwai Yang, Hou-Wei Chu, Chien-Hsiun Chen, Yi-Wen Hsiao, Chien-Yueh Lee, Li-Mei Chiang, Qi-You Yu, Chuhsing Kate Hsiao, Ching-Yu Julius Chen, Pei-Ei Wu, Chien-Hua Pai, Eric Y. Chuang, Chen-Yang Shen
Summary: This study established the first genomic database for Han Chinese in Taiwan, identifying hypertension and hyperlipidemia-associated variants and developing prediction models. Additionally, an online database for exploring racial differences in the important cardiac gene SCN5A was created, and population-specific SNVs in genes related to drug metabolism and blood clotting were discovered.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Endocrinology & Metabolism
LaTonya J. Hickson, Alfonso Eirin, Sabena M. Conley, Timucin Taner, Xiaohui Bian, Ahmed Saad, Sandra M. Herrmann, Ramila A. Mehta, Travis J. McKenzie, Todd A. Kellogg, James L. Kirkland, Tamar Tchkonia, Ishran M. Saadiq, Hui Tang, Kyra L. Jordan, Xiangyang Zhu, Mathew D. Griffin, Andrew D. Rule, Andre J. van Wijnen, Stephen C. Textor, Lilach O. Lerman
Summary: This study investigated the impact of diabetic kidney disease (DKD) on human adipose-derived MSCs, finding that DKD reduced the migration capability of MSCs but did not affect their function, secretome profile, and immunomodulatory activities contributing to repair. Few DKD-MSC functions were affected by patient characteristics, but DKD-MSC from participants on metformin therapy showed lower senescence-associated beta-galactosidase activity.
Article
Computer Science, Artificial Intelligence
Tim Chen, D. Kuo, C. Y. J. Chen
Summary: This paper discusses the robust controller design for fuzzy C-means clustering algorithms that are resilient to plant disturbances and controller variations. The control and stability issues in nonlinear systems are studied using the Takagi-Sugeno fuzzy model, incorporating a new integral inequality and flexible stability criteria through linear matrix inequalities (LMIs). The method does not require the controller and control system to have the same number of membership functions and mathematical rules, demonstrating efficacy for large-scale nonlinear systems.
Article
Computer Science, Information Systems
Yangjun Chen, Gagandeep Singh
Summary: The article presents a new method to store the transitive closure of a graph G in the form of interval spanning trees (forests). By associating each vertex v with two sequences, it efficiently checks the reachability of vertices. Extensive experiments show that this method outperforms all previous methods in terms of index construction times, index sizes, and query times.
ACM TRANSACTIONS ON DATABASE SYSTEMS
(2021)
Article
Cell Biology
Shih-Yao Lin, Yeh-Han Wang, Chih-Yi Hsu, Yi-Jen Chen, Chiung-Ru Lai, Jen-Fan Hang
Summary: This study aimed to evaluate HER2 immunohistochemistry in ovarian clear cell carcinoma using two antibodies and two scoring guidelines. The results showed HER2 amplification in 7% of cases, significantly associated with papillary-predominant growth patterns. A combination of 4B5 IHC and gastric guidelines provided the best sensitivity in predicting HER2 amplification.
Article
Urology & Nephrology
Seo Rin Kim, Amrutesh S. Puranik, Kai Jiang, Xiaojun Chen, Xiang-Yang Zhu, Ian Taylor, Alireza Khodadadi-Jamayran, Amir Lerman, LaTonya J. Hickson, Bennett G. Childs, Stephen C. Textor, Tamara Tchkonia, Timothy B. Niewold, James L. Kirkland, Lilach O. Lerman
Summary: The study found that chronic renal ischemia may lead to maladaptive tubular cell senescence, which impairs kidney function and structure. Clearing senescent cells that highly express specific genes or using drug combinations can improve stenotic kidney function, highlighting the importance of delaying chronic ischemic renal injury.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Genetics & Heredity
Ying-Jiun C. Chen, Sharon Y. R. Dent
Summary: The SAGA complex, a evolutionarily conserved transcriptional coactivator, plays essential roles in regulating gene expression, growth, development, and responses to various stresses across different organisms. In metazoans, it is also involved in immune cell differentiation and the initiation and progression of diseases, including cancers.
EPIGENETICS & CHROMATIN
(2021)
Review
Cell & Tissue Engineering
LaTonya J. Hickson, Tala Abedalqader, Gift Ben-Bernard, Jayla M. Mondy, Xiaohui Bian, Sabena M. Conley, Xiangyang Zhu, Sandra M. Herrmann, Aleksandra Kukla, Elizabeth C. Lorenz, Seo Rin Kim, Bjorg Thorsteinsdottir, Lilach O. Lerman, M. Hassan Murad
Summary: Cell-based interventions showed significant improvement in kidney function and reduction in injury in diabetic animal models of kidney disease. Treatment-related factors, such as cell type, tissue source, cell dose, and administration route, played a role in modifying treatment effects.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ying-Jiun C. Chen, Evangelia Koutelou, Sharon Y. R. Dent
Summary: Protein acetylation is a highly conserved post-translational modification and has been recognized for its importance in chromatin organization and DNA processes for nearly 60 years. Recent advances have revealed new roles of acetylation regulators and their complex functional networks.
Article
Respiratory System
Calvin You Jia Chen, Min Sen Yew, John Arputhan Abisheganaden, Huiying Xu
Summary: This study aimed to identify predictors of influenza PCR positivity in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed that higher temperature, higher heart rate, low white cell count (especially when < 8.1 x10(9)/L), and non-eosinophilic exacerbations were independent predictors of influenza PCR positivity.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Carlo Briguori, Roy O. Mathew, Zhen Huang, Kreton Mavromatis, LaTonya J. Hickson, Wei Ling Lau, Anoop Mathew, Sandeep Mahajan, David C. Wheeler, Kathleen J. Claes, Gang Chen, Fernando E. B. Nolasco, Gregg W. Stone, Jerome L. Fleg, Mandeep S. Sidhu, Frank W. Rockhold, Glenn M. Chertow, Judith S. Hochman, David J. Maron, Sripal Bangalore
Summary: The effect of treatment strategies on the timing of dialysis initiation in participants with both chronic coronary disease and advanced chronic kidney disease is explored. The study found that an initial invasive management strategy is associated with an accelerated time to initiation of maintenance dialysis for kidney failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Demilade A. Adedinsewo, Ivan E. Porter, Richard O. White, LaTonya J. Hickson
Summary: This article reviews recent literature on racial and ethnic disparities in cardiovascular disease among adults with chronic kidney disease. Despite advances in medical care, individuals with chronic kidney disease continue to bear a high burden of clinical and subclinical cardiovascular disease. Multiple racial and ethnic factors influence the pathophysiology, burden, and clinical outcomes of cardiovascular disease in chronic kidney disease patients, leading to increased morbidity and mortality among racial and ethnic minority populations.
CURRENT CARDIOVASCULAR RISK REPORTS
(2022)
Article
Urology & Nephrology
Elizabeth C. Lorenz, LaTonya J. Hickson, Marie C. Hogan, Cassie C. Kennedy
Summary: This study examined the safety, feasibility, and preliminary efficacy of a 4-week supervised exercise intervention on frailty in patients with chronic kidney disease (CKD). The results showed that the intervention was safe, associated with an excellent completion rate, and improved frailty parameters in CKD patients. This study provides important preliminary data for future larger randomized studies.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Engineering, Civil
Tim Chen, Y. C. Huang, C. C. Hung, Suzanne Frias, J. A. Muhammad, C. Y. J. Chen
Summary: This paper proposes an intelligent controller for ensuring the simulation stability of a mathematical nonlinear system, utilizing an intelligent evolutionary fuzzy NN model and the concept of linear differential inclusion, with asymptotic stability guaranteed by Lyapunov mathematics function and linear matrix inequality.
SMART STRUCTURES AND SYSTEMS
(2021)
Article
Computer Science, Information Systems
Yangjun Chen, Hoang Hai Nguyen
Summary: This paper discusses an efficient index mechanism for string matching with k differences, particularly suitable for searching DNA databases. The time complexity of the method is bounded by O(k * |T|), with promising results shown in extensive experiments.
PROCEEDINGS OF THE VLDB ENDOWMENT
(2021)