Journal
FOOD CHEMISTRY
Volume 173, Issue -, Pages 897-904Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.10.056
Keywords
Liquid milk; Milk powder; UPLC-MS/MS; Automated exclusion SPE; Matrix effects; Permanent postcolumn infusion (PCI)
Funding
- Ministry of Agriculture [2011-G5]
- National Science & Technology Pillar Plan [2012BAB19B09]
- Natural Science Foundation of China [31000787]
- Special Fund for Agro-scientific Research in the Public Interest [201203094]
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An automated, size-exclusion solid phase extraction (SPE)-UPLC-MS/MS protocol without pre-treatment of samples was developed to screen for four mycotoxins (OTA, ZEN, AFB(1), and AFM(1)) in liquid milk and milk powder. Firstly, a mixed macropore-silica gel cartridge was established as a size-exclusion SPE column. The proposed methodology could be a candidate in green analytical chemistry because it saves on manpower and organic solvent. Permanent post-column infusion of mycotoxin standards was used to quantify matrix effects throughout the chromatographic run. Matrix-matched calibration could effectively compensate for matrix effects, which may be caused by liquid milk or milk powder matrix. Recovery of the four mycotoxins in fortified liquid milk was in the range 89-120% and RSD 2-9%. The LOD for the four mycotoxins in liquid milk and milk powder were 0.05-2 ng L-1 and 0.25-10 ng kg(-1), respectively. The LOQ for the four mycotoxins in liquid milk and milk powder were 0.1-5 ng L-1 and 0.5-25 ng kg(-1), respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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