The intake of a hazelnut skin extract improves the plasma lipid profile and reduces the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in hamsters fed a high-fat diet

The effects on lipid and glucose metabolism of a hazelnut skin extract (FIBEROX (TM)) administrated during 8 weeks (HFD-FBX8w group) or during the last 4 weeks of the study (HFD-FBX4w group) to Golden Syrian hamsters fed a high-fat diet (HFD) for 8 weeks were investigated. FIBEROX (TM) consumption reversed the increase in total and LDL plasma cholesterol induced by the HFD feeding in both HFD-FBX groups and decreased the circulating levels of free fatty acids and triglycerides in the HFD-FBX4w animals. The higher excretion of bile acids found in the faeces of both groups of hamsters fed the FIBEROX (TM) suggests that this mechanism is involved in the cholesterol-lowering effects of the extract. Furthermore, FIBEROX (TM) intake sharply decreased the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in both HFD-FBX groups. In conclusion, the consumption of FIBEROX (TM) improves different risk factors associated with cardiovascular disease and colon cancer. (C) 2014 Elsevier Ltd. All rights reserved.