Insights in particulate matter-induced allergic airway inflammation: Focus on the epithelium

Mechanistic link between diesel exhaust particles and respiratory reflexes

(2018) Ryan K. Robinson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of IL-6 released from pulmonary epithelial cells in diesel UFP-induced endothelial activation

(2017) Rossella Bengalli et al.   ENVIRONMENTAL POLLUTION

Particulate metal bioaccessibility in physiological fluids and cell culture media: Toxicological perspectives

(2017) Bérénice Leclercq et al.   ENVIRONMENTAL RESEARCH

Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression

(2017) Lei Song et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Human bronchial epithelium orchestrates dendritic cell activation in severe asthma

(2017) Delphine Gras et al.   EUROPEAN RESPIRATORY JOURNAL

A Phase 1 Study of ANB020, an anti-IL-33 monoclonal Antibody in Healthy Volunteers

(2017) Marco Londei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dysregulation of type 2 innate lymphoid cells and T H 2 cells impairs pollutant-induced allergic airway responses

(2017) Katrien C. De Grove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients

(2017) Matthew Loxham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Air Pollution and Mortality in the Medicare Population

(2017) Qian Di et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice

(2017) Hetong Wang et al.   Scientific Reports

Whole Blood Cytokine Response to Local Traffic-Related Particulate Matter in Peruvian Children With and Without Asthma

(2017) Jesse P. Negherbon et al.   Frontiers in Pharmacology

Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway

(2017) Jian Wang et al.   Journal of Thoracic Disease

Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic InflammationNovelty and Significance

(2016) C. Arden Pope et al.   CIRCULATION RESEARCH

Identification of PM 10 characteristics involved in cellular responses in human bronchial epithelial cells (Beas-2B)

(2016) Rosette Van Den Heuvel et al.   ENVIRONMENTAL RESEARCH

Investigation of selenium pretreatment in the attenuation of lung injury in rats induced by fine particulate matters

(2016) Jie Liu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Association between inflammation processes, DNA damage, and exposure to environmental pollutants

(2016) Anelise Barth et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice

(2016) Yuefei Jin et al.   ENVIRONMENTAL TOXICOLOGY

Effect of GST variants on lung function following diesel exhaust and allergen co-exposure in a controlled human crossover study

(2016) Xin Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Asthma inflammatory phenotypes show differential microRNA expression in sputum

(2016) Tania Maes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pro- and Anti-Inflammatory Role of ChemR23 Signaling in Pollutant-Induced Inflammatory Lung Responses

(2016) Sharen Provoost et al.   JOURNAL OF IMMUNOLOGY

Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma

(2016) Nestor A Molfino et al.   BMJ Open

Aeroparticles, Composition, and Lung Diseases

(2016) Carlos I. Falcon-Rodriguez et al.   Frontiers in Immunology

The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 μm

(2015) Jeremy A. Hirota et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation

(2015) Rohit Divekar et al.   Current Opinion in Allergy and Clinical Immunology

Epithelial cytokines and pulmonary allergic inflammation

(2015) Clare M Lloyd et al.   CURRENT OPINION IN IMMUNOLOGY

Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults

(2015) Jaime E. Mirowsky et al.   Environmental Health

Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats

(2015) Ruijin Li et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Oxidative stress and endocytosis are involved in upregulation of interleukin-8 expression in airway cells exposed to PM2.5

(2015) Zhen Yan et al.   ENVIRONMENTAL TOXICOLOGY

A summary of the new GINA strategy: a roadmap to asthma control

(2015) Helen K. Reddel et al.   EUROPEAN RESPIRATORY JOURNAL

Effects on health of air pollution: a narrative review

(2015) Pier Mannuccio Mannucci et al.   Internal and Emergency Medicine

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

(2015) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Predictors of interleukin-33 and thymic stromal lymphopoietin levels in cord blood

(2015) Jillian Ashley-Martin et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study

(2015) Chris Carlsten et al.   THORAX

The Effects on Bronchial Epithelial Mucociliary Cultures of Coarse, Fine, and Ultrafine Particulate Matter From an Underground Railway Station

(2015) Matthew Loxham et al.   TOXICOLOGICAL SCIENCES

Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice

(2015) Hsiao-Chi Chuang et al.   TOXICOLOGY LETTERS

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

Airway Epithelium Interactions with Aeroallergens: Role of Secreted Cytokines and Chemokines in Innate Immunity

(2015) Vivek D. Gandhi et al.   Frontiers in Immunology

Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells

(2015) Zhixiang Zhou et al.   PLoS One

Epithelial Interleukin-25 Is a Key Mediator in Th2-High, Corticosteroid-Responsive Asthma

(2014) Dan Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Autonomic Reflex Arcs in Cardiovascular Responses to Air Pollution Exposure

(2014) Christina M. Perez et al.   Cardiovascular Toxicology

Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33

(2014) A. M. Shadie et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Biological Modulators in Eosinophilic Diseases

(2014) Panida Sriaroon et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Pro-inflammatory response and oxidative stress induced by specific components in ambient particulate matter in human bronchial epithelial cells

(2014) Lawei Yang et al.   ENVIRONMENTAL TOXICOLOGY

Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

(2014) M. Adam et al.   EUROPEAN RESPIRATORY JOURNAL

Allergens and the airway epithelium response: Gateway to allergic sensitization

(2014) Bart N. Lambrecht et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Outdoor air pollution and asthma

(2014) Michael Guarnieri et al.   LANCET

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles

(2014) Sam Parnia et al.   RESPIRATORY RESEARCH

Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells

(2014) Rakesh K. Kumar et al.   RESPIROLOGY

Harmful effects of particulate air pollution: Identifying the culprits

(2014) Matthew Loxham   RESPIROLOGY

Biological Dose Response to PM2.5: Effect of Particle Extraction Method on Platelet and Lung Responses

(2014) Laura S. Van Winkle et al.   TOXICOLOGICAL SCIENCES

Toll like receptor-3 priming alters diesel exhaust particle-induced cytokine responses in human bronchial epithelial cells

(2014) Nicolai S. Bach et al.   TOXICOLOGY LETTERS

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

(2014) Dagmar A Kuhn et al.   Beilstein Journal of Nanotechnology

Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project

(2014) G. Cesaroni et al.   BMJ-British Medical Journal

Nasal Neurogenic Inflammation Markers Increase after Diesel Exhaust Inhalation in Individuals with Asthma

(2013) Francesco Sava et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway epithelial regulation of pulmonary immune homeostasis and inflammation

(2013) Teal S. Hallstrand et al.   CLINICAL IMMUNOLOGY

pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers

(2013) TM Lima et al.   Clinics

Rat lung response to ozone and fine particulate matter (PM2.5) exposures

(2013) Guanghe Wang et al.   ENVIRONMENTAL TOXICOLOGY

Differential proinflammatory responses induced by diesel exhaust particles with contrasting PAH and metal content

(2013) Annike I. Totlandsdal et al.   ENVIRONMENTAL TOXICOLOGY

Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituents and sources of emission

(2013) Flemming R. Cassee et al.   INHALATION TOXICOLOGY

MicroRNA-375 Regulation of Thymic Stromal Lymphopoietin by Diesel Exhaust Particles and Ambient Particulate Matter in Human Bronchial Epithelial Cells

(2013) B. Bleck et al.   JOURNAL OF IMMUNOLOGY

Highway Proximity Associations with Blood Markers of Inflammation: Evidence for a Role for IL-1β

(2013) Doug Brugge et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project

(2013) Rob Beelen et al.   LANCET

Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

(2013) Kunihiko Hiraiwa et al.   MEDIATORS OF INFLAMMATION

Eosinophils in the Spotlight: Eosinophilic airway inflammation in nonallergic asthma

(2013) Guy G Brusselle et al.   NATURE MEDICINE

A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

(2013) Ranjini M Krishnan et al.   Particle and Fibre Toxicology

Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure

(2013) Andrew J Ghio et al.   Particle and Fibre Toxicology

Milano Summer Particulate Matter (PM10) Triggers Lung Inflammation and Extra Pulmonary Adverse Events in Mice

(2013) Francesca Farina et al.   PLoS One

Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM2.5 exposure in human bronchial epithelial cells

(2012) Kiran Ramgolam et al.   ARCHIVES OF TOXICOLOGY

Prooxidant and Proinflammatory Potency of Air Pollution Particulate Matter (PM2.5–0.3) Produced in Rural, Urban, or Industrial Surroundings in Human Bronchial Epithelial Cells (BEAS-2B)

(2012) Mona Dergham et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dynamic role of epithelium-derived cytokines in asthma

(2012) Kathleen R. Bartemes et al.   CLINICAL IMMUNOLOGY

Epigenetics, Asthma, and Allergic Diseases: A Review of the Latest Advancements

(2012) Stephanie Lovinsky-Desir et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Relationship between physicochemical characterization and toxicity of fine particulate matter (PM2.5) collected in Dakar city (Senegal)

(2012) Denis Dieme et al.   ENVIRONMENTAL RESEARCH

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

(2012) Jeremy A. Hirota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenetic mechanisms and the development of asthma

(2012) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium

(2012) Jamshid Pourazar et al.   Particle and Fibre Toxicology

Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells

(2012) Weidong Wu et al.   Particle and Fibre Toxicology

Effects of particulate matter on inflammatory markers in the general adult population

(2012) Dai-Hua Tsai et al.   Particle and Fibre Toxicology

Genomics and the respiratory effects of air pollution exposure

(2012) JOHN W. HOLLOWAY et al.   RESPIROLOGY

Development of a repeated exposure protocol of human bronchial epithelium in vitro to study the long-term effects of atmospheric particles

(2012) Laura Boublil et al.   TOXICOLOGY IN VITRO

Effects of second hand smoke on airway secretion and mucociliary clearance

(2012) Yanyan Liu et al.   Frontiers in Physiology

Intrinsic Phenotypic Differences of Asthmatic Epithelium and Its Inflammatory Responses to Respiratory Syncytial Virus and Air Pollution

(2011) Tillie-Louise Hackett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Urban particulate matter activates Akt in human lung cells

(2011) Todd L. Watterson et al.   ARCHIVES OF TOXICOLOGY

Ambient Particulate Matter Induces Interleukin-8 Expression through an Alternative NF-κB (Nuclear Factor-Kappa B) Mechanism in Human Airway Epithelial Cells

(2011) Robert Silbajoris et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PM 2.5 collected in a residential area induced Th1-type inflammatory responses with oxidative stress in mice

(2011) Eun-Jung Park et al.   ENVIRONMENTAL RESEARCH

TACE/TGF- /EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components

(2011) J. Ovrevik et al.   EUROPEAN RESPIRATORY JOURNAL

The sentinel role of the airway epithelium in asthma pathogenesis

(2011) Stephen T. Holgate   IMMUNOLOGICAL REVIEWS

Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2 dependent

(2011) Sharen Provoost et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors

(2011) Rebecca N. Bauer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

(2011) Aarti Shikotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic and epigenetic influence on the response to environmental particulate matter

(2011) Hong Ji et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Air pollution and asthma control in the Epidemiological study on the Genetics and Environment of Asthma

(2011) Bénédicte Jacquemin et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

NLRP3/Caspase-1-Independent IL-1  Production Mediates Diesel Exhaust Particle-Induced Pulmonary Inflammation

(2011) S. Provoost et al.   JOURNAL OF IMMUNOLOGY

Composition of Air Pollution Particles and Oxidative Stress in Cells, Tissues, and Living Systems

(2011) Andrew J. Ghio et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Exposure to Moderate Air Pollution during Late Pregnancy and Cord Blood Cytokine Secretion in Healthy Neonates

(2011) Philipp Latzin et al.   PLoS One

Respiratory health effects of diesel particulate matter

(2011) ZORAN D. RISTOVSKI et al.   RESPIROLOGY

Fine particulate matter from urban ambient and wildfire sources from California’s San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells

(2011) L.S. Nakayama Wong et al.   TOXICOLOGY IN VITRO

Differential effects of the particle core and organic extract of diesel exhaust particles

(2011) Annike Irene Totlandsdal et al.   TOXICOLOGY LETTERS

Increased IL-33 expression by epithelial cells in bronchial asthma

(2010) David Préfontaine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Outdoor air pollution and uncontrolled asthma in the San Joaquin Valley, California

(2010) Y.-Y. Meng et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Traffic-related air pollution and incident asthma in a high-risk birth cohort

(2010) C. Carlsten et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance

(2010) Juan C. CARABALLO et al.   RESPIROLOGY

How does diesel exhaust impact asthma?

(2010) J. R. Balmes   THORAX

Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

(2010) M. Kerkhof et al.   THORAX

Redox Control of Asthma: Molecular Mechanisms and Therapeutic Opportunities

(2009) Suzy A.A. Comhair et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ)

(2009) Aila Mirtes Teles et al.   ARCHIVES OF TOXICOLOGY

Self-Reported Truck Traffic on the Street of Residence and Symptoms of Asthma and Allergic Disease: A Global Relationship in ISAAC Phase 3

(2009) Bert Brunekreef et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Exposure to traffic: Lung function and health status in adults with asthma

(2009) John R. Balmes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diesel Exhaust Particles Stimulate Adaptive Immunity by Acting on Pulmonary Dendritic Cells

(2009) Sharen Provoost et al.   JOURNAL OF IMMUNOLOGY

Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro

(2009) Andrea D Lehmann et al.   Particle and Fibre Toxicology

Size-partitioning of an urban aerosol to identify particle determinants involved in the proinflammatory response induced in airway epithelial cells

(2009) Kiran Ramgolam et al.   Particle and Fibre Toxicology

Traffic-related air pollution correlates with adult-onset asthma among never-smokers

(2009) N Kunzli et al.   THORAX

Role of Paris PM2.5 components in the pro-inflammatory response induced in airway epithelial cells

(2009) Augustin Baulig et al.   TOXICOLOGY

Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution

(2009) J. Øvrevik et al.   TOXICOLOGY

Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM2.5 organic extract from Puerto Rico

(2009) Enrique Fuentes-Mattei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles

(2009) Tamara L. Tal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of COX-2 Expression and IL-6 Release by Particulate Matter in Airway Epithelial Cells

(2008) Yutong Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Isolation and quantitative estimation of diesel exhaust and carbon black particles ingested by lung epithelial cells and alveolar macrophages in vitro

(2008) Rajiv K. Saxena et al.   BIOTECHNIQUES

Pathogenesis of Asthma

(2008) STEPHEN T. HOLGATE   CLINICAL AND EXPERIMENTAL ALLERGY

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

(2008) Ning Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Associations between Multiple Environmental Exposures and Glutathione S-transferase P1 on Persistent Wheezing in a Birth Cohort

(2008) Kathy T. Schroer et al.   JOURNAL OF PEDIATRICS

Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice

(2008) Syunji Yokota et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles

(2007) John M. Veranth et al.   TOXICOLOGY IN VITRO