Review
Biochemistry & Molecular Biology
Shouji Matsushima, Junichi Sadoshima
Summary: Oxidative stress plays a critical role in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression of Nox-derived ROS can prevent mitochondrial dysfunction and endoplasmic reticulum (ER) stress, leading to reduced myocardial I/R injury. However, minimal levels of ROS by either Nox2 or Nox4 are required for energy metabolism during I/R in order to preserve the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and peroxisome proliferator-activated receptor-alpha (PPAR alpha). Furthermore, extreme suppression of Nox activity may lead to reductive stress and paradoxical increases in ROS levels. Nox4 has different roles in organelles such as mitochondria, ER, and ER-mitochondria contact sites (MAMs). Mitochondrial Nox4 has a detrimental effect, causing ROS-induced mitochondrial dysfunction during I/R, whereas Nox4 in the ER and MAMs may potentially protect against I/R injury through regulation of autophagy and MAM function, respectively. Although Nox isoforms are potential therapeutic targets for I/R injury, it is important to optimize ROS levels and selectively inhibit Nox4 in mitochondria to maximize the effect of intervention.
Review
Pharmacology & Pharmacy
Paul Victor, Dronamraju Sarada, Kunka Mohanram Ramkumar
Summary: Cellular stress and inflammation have become significant factors in disease pathology over the past few decades. Endoplasmic reticulum stress, oxidative stress, and inflammatory responses are crucial mechanisms that exacerbate the progression of various diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Biochemistry & Molecular Biology
Lina Cao, Jingjing Zhang, Yan Du, Min Sun, Yue Xiang, Yulu Sheng, Xiangmei Ren, Jihong Shao
Summary: Sodium selenite (Na2SeO3) exhibits anti-tumor activity in MCF7 cells by inducing apoptosis and activating the endoplasmic reticulum stress pathway. Oxidative stress and endoplasmic reticulum stress interact to regulate the survival of cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Danyang Li, Ruqin Lin, Yangyang Xu, Qingmei Chen, Fengru Deng, Yiqun Deng, Jikai Wen
Summary: Long-term exposure to Cereulide causes oxidative stress in liver and kidney tissues, leading to activation of ER stress pathways and ultimately apoptosis and tissue damage. Inhibition of these pathways can reduce the toxic effects of this toxin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xintong Bian, Ningke Fan, Meng Li, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song, Siqiao Li, Wei Cheng
Summary: A hepatocellular carcinoma (HCC) cell-derived ER vesicle (ER-horse) has been developed for precise HCC nanotherapy by imitating the physiological function of endoplasmic reticulum (ER) and triggering excessive ER stress and apoptosis. The findings provide a new method for HCC nanotherapy via interference of ER stress signaling.
Review
Medicine, Research & Experimental
Qirui Duan, Ying Zhou, Dong Yang
Summary: Airway hyperresponsiveness is a major clinical phenomenon in lung diseases and can lead to severe complications during the perioperative period. This review focuses on the effects of endoplasmic reticulum stress on immune cells, inflammation, and remodeling in the airways, with the aim of understanding the mechanisms and finding prevention strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Flavia Ferreira Fontenele, Guilherme Lopes Goncalves, Maria Oliveira-Souza
Summary: The study explored the relationship between high plasma angiotensin II (Ang II) levels and chronic kidney diseases (CKDs), revealing that prolonged Ang II infusion/AT1 receptor activation can induce oxidative stress and endoplasmic reticulum (ER) stress. Ang II also affects tubular Na+ transport mechanisms. The findings suggest the therapeutic potential of losartan in preventing the progression of Ang II-induced CKD by reducing oxidative and ER stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Soraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and beta-cell dysfunction, and its incidence is increasing worldwide. Research has shown that long-term high blood sugar leads to beta-cell failure and death through endoplasmic reticulum (ER) stress. Herbal compounds such as ginsenoside compound K, baicalein, quercetin, and resveratrol have demonstrated significant improvement of T2DM through modulation of ER stress. These findings suggest that herbal constituents have the potential to prevent and treat various complications of T2DM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Paola Toledo-Ibelles, Roxana Gutierrez-Vidal, Sandra Calixto-Tlacomulco, Blanca Delgado-Coello, Jaime Mas-Oliva
Summary: This study investigates the molecular mechanisms associated with NAFLD development and oxidative stress due to a high-fat diet. Results show that the high-fat diet in rabbits led to signs of NAFLD and altered purine metabolism, indicating a compensation mechanism in response to oxidative stress.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Arshag D. Mooradian, Michael J. Haas
Summary: Despite advances in cardiovascular disease prevention, there is still a significant risk of adverse cardiovascular events. Reducing cellular stresses, particularly inflammatory stress and endoplasmic reticulum stress, may further reduce cardiovascular disease risk.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Ophthalmology
Rong Li, Guomin Yao, Lingxiao Zhou, Min Zhang, Jin Yan
Summary: This study found that ghrelin can inhibit high glucose-induced retinal angiogenesis through GHSR-1a, and alleviation of ER stress may be one of the mechanisms underlying this effect.
Article
Neurosciences
Osman Sinen, Mehmet Bulbul, Narin Derin, Ayse Ozkan, Guven Akcay, Mutay Aydin Aslan, Aysel Agar
Summary: This study demonstrated that central administration of NPS improved non-motor symptoms in 6-OHDA-induced parkinsonian rats, including reducing cognitive errors, suppressing anxiety, and improving depression. Additionally, NPS treatment attenuated the reduction in TH neuronal number in parkinsonian rats.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Review
Chemistry, Organic
Mutay Aslan
Summary: This review highlights the essential roles of omega-3 and omega-6 fatty acids in metabolic homeostasis, as well as the functions of sphingolipids in cell growth and apoptosis. Tandem mass spectrometric analyses can directly measure quantitative changes in lipids across different matrices.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2021)
Article
Oncology
Mutay Aslan, Ebru Afsar, Esma Kirimlioglu, Tugce Ceker, Cagatay Yilmaz
Summary: The study showed that treatment with thymoquinone (TQ) resulted in ceramide accumulation and endoplasmic reticulum stress in cancer cells, while decreasing S1P, C1P, and NF-kappa B mediated cell survival, ultimately promoting cancer cell death through apoptosis.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Gul Ozbey, Dilara Nemutlu-Samur, Hande Parlak, Sendegul Yildirim, Mutay Aslan, Gamze Tanriover, Aysel Agar
PHARMACOLOGICAL REPORTS
(2020)
Article
Immunology
Bora Dinc, Ilker Onguc Aycan, Mutay Aslan, Necmiye Hadimioglu, Zeki Ertug, Abdullah Kisaoglu, Ismail Demiryilmaz
Summary: This study evaluated plasma neuron-specific enolase (NSE) and S100 beta levels in orthotopic liver transplantation, finding that levels were significantly higher in ESLF patients preoperatively and decreased postoperatively. NSE and S100 beta levels correlated significantly with MELD and CTP scores in ESLF patients with HE. Levels in healthy donors increased in the first month post-hepatectomy and decreased by the sixth month.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Toxicology
Mutay Aslan, Ozlem Elpek, Bahar Akkaya, Hazal Tuzcu Balaban, Ebru Afsar
Summary: The study found that ER stress causes hepatic and renal toxicity as well as CER-induced PGE2 formation in the liver and kidneys.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Neurosciences
Eren Ogut, Guven Akcay, Fatos Belgin Yildirim, Narin Derin, Mutay Aslan
Summary: In Wistar rats, syringic acid increased dopamine levels and facilitated cognitive and behavioral functions related to short-term and recognition memory.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Baris Akgul, Ilker Onguc Aycan, Enis Hidisoglu, Ebru Afsar, Sendegul Yildirim, Gamze Tanriover, Nesil Coskunfirat, Suat Sanli, Mutay Aslan
Summary: The study demonstrated that TQ could alleviate CNS and cardiovascular toxicity induced by prilocaine.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ozge Guzelad, Ayse Ozkan, Hande Parlak, Osman Sinen, Ebru Afsar, Eren Ogut, Fatos Belgin Yildirim, Mehmet Bulbul, Aysel Agar, Mutay Aslan
Summary: The study demonstrated that syringic acid has neuroprotective properties in a rat model of 6-OHDA-induced Parkinson's disease. It can slow down the progression of the disease, improve motor dysfunction, and reduce oxidative stress and inflammation.
METABOLIC BRAIN DISEASE
(2021)
Article
Genetics & Heredity
Kubra Aksu, Ezgi Golal, Mutay Aydin Asian, Ismail Ustunel, Nuray Acar
Summary: This study suggests that sirtuin-1 may play a role in embryo implantation against oxidative stress through FoxO1-SOD signaling. In SRT1720-treated mice, expressions of sirtuin-1 and FoxO1 increased at implantation sites, while ROS/RNS levels decreased and SOD activity increased.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Pharmacology & Pharmacy
Cagatay Yilmaz, Sadi Koksoy, Tugce Ceker, Mutay Aslan
Summary: The study found that diclofenac can inhibit colorectal tumor growth and metastasis in COX-2 overexpressing colon cancer cells by increasing apoptosis and decreasing the expression of CD44 and ICAM-1.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Immunology
Bora Dinc, Vural Taner Yilmaz, Mutay Aslan, Ilker Onguc Aycan, Nihal Kiraz, Abdullah Kisaoglu, Ozgur Dandin, Necmiye Hadimioglu, Zeki Ertug
Summary: The kidney functions were impaired in donors post-surgery but improved in recipients. Neuromarkers decreased in recipients but remained unchanged in donors, indicating no evidence of neurotoxicity in kidney transplantation for either recipients or donors.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Neurosciences
Ayse Ozkan, Mutay Aydin Aslan, Osman Sinen, Mustafa Munzuroglu, Narin Derin, Hande Parlak, Mehmet Bulbul, Aysel Agar
Summary: This study demonstrates that Adropin enhances spatial memory capacity through Akt/CREB/BDNF signaling pathways, indicating its potential neuroprotective effects.
Article
Neurosciences
Dilara Nemutlu Samur, Guven Akcay, Sendegul Yildirim, Ayse Ozkan, Tugce Ceker, Narin Derin, Gamze Tanriover, Mutay Aslan, Aysel Agar, Gul Ozbey
Summary: This study found that vortioxetine treatment significantly reduced rotenone-induced neurodegeneration, improved motor and cognitive dysfunction, decreased depression-like behaviors without affecting anxiety-like parameters. Vortioxetine also restored the impaired inflammatory response and affected neurotransmitter levels in brain tissues.
Article
Clinical Neurology
Sevim Ercan, Goksun Basaranlar
Summary: This study aimed to investigate the effects of ghrelin on sulfite-induced changes in hippocampal oxidative status, spatial learning and locomotor activity in rats. The results showed that sulfite induced oxidative stress in the hippocampus, which was prevented by ghrelin administration. However, ghrelin had no significant effects on spatial learning, memory, and locomotion.
NEUROLOGICAL RESEARCH
(2023)
