Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

(2018) Kristoffer Peterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into Thiol–Aromatic Interactions: A Stereoelectronic Basis for S–H/π Interactions

(2017) Christina R. Forbes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

(2016) Tamara Delaine et al.   CHEMBIOCHEM

The Halogen Bond

(2016) Gabriella Cavallo et al.   CHEMICAL REVIEWS

Recent Developments of C-Aryl Glucoside SGLT2 Inhibitors

(2016) Yang Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability

(2016) Simon Kleeb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

(2015) Alberto Fernández-Tejada et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

(2015) Brett R. Beno et al.   JOURNAL OF MEDICINAL CHEMISTRY

FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

(2015) Simon Kleeb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

(2014) Horst Prescher et al.   ACS Chemical Biology

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

(2014) Vishal Kumar Rajput et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

(2013) Jason E. Hudak et al.   CHEMISTRY & BIOLOGY

Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach

(2013) Jonas Egger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

(2010) Bader A. Salameh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity

(2010) Irina V. Nesmelova et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

(2010) Carl Diehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

(2008) Ian Cumpstey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Galectin-Inhibitory Thiodigalactoside Ester Derivatives Have Antimigratory Effects in Cultured Lung and Prostate Cancer Cells

(2008) Tamara Delaine et al.   JOURNAL OF MEDICINAL CHEMISTRY