Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)

(2017) Michelle A Lawson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

(2017) Parish P. Sedghizadeh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties

(2017) Erica J. Carbone et al.   Nanomedicine-Nanotechnology Biology and Medicine

Coordination abilities of N-methyl alkylaminomethane-1,1-diphosphonic acids towards zinc(II), magnesium(II) and calcium(II) metal ions. Equilibrium studies in aqueous solutions

(2017) Magdalena Szpak et al.   POLYHEDRON

Targeted delivery to bone and mineral deposits using bisphosphonate ligands

(2016) Lisa E. Cole et al.   ADVANCED DRUG DELIVERY REVIEWS

Electrochemical and spectroscopic investigations of selected N -heteroalkylaminomethylenebisphosphonic acids with Pb(II) ions

(2016) Agnieszka Dobosz et al.   COORDINATION CHEMISTRY REVIEWS

Metal-organodiphosphonate chemistry: Hydrothermal syntheses and structures of Ca(II) coordination polymers with xylyldiphosphonate ligands

(2016) Valerie Lopez-Diaz et al.   INORGANICA CHIMICA ACTA

Thermodynamic study of the interaction between calcium and zoledronic acid by calorimetry

(2016) Mohamed A. Mostefa Side Larbi et al.   JOURNAL OF CHEMICAL THERMODYNAMICS

Hydroxyapatite substituted by transition metals: experiment and theory

(2016) M. E. Zilm et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Dual-functionalisation of gelatine nanoparticles with an anticancer platinum(ii)–bisphosphonate complex and mineral-binding alendronate

(2016) Kambiz Farbod et al.   RSC Advances

First-principles study of structural and surface properties of (001) and (010) surfaces of hydroxylapatite and carbonated hydroxylapatite

(2016) Gianfranco Ulian et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

(2015) Ruggero Bosco et al.   APPLIED SURFACE SCIENCE

Novel Pullulan Bioconjugate for Selective Breast Cancer Bone Metastases Treatment

(2015) Gwénaëlle Bonzi et al.   BIOCONJUGATE CHEMISTRY

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

(2015) Ali Saad et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Antimicrobial Evaluation of Newly SynthesizedN,S-Bisphosphonate Derivatives

(2015) Wafaa M. Abdou et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Development and dissolution studies of bisphosphonate (clodronate)-containing hydroxyapatite-polylactic acid biocomposites for slow drug delivery

(2015) Innocent J. Macha et al.   Journal of Tissue Engineering and Regenerative Medicine

Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters

(2015) Elina Puljula et al.   ACS Medicinal Chemistry Letters

Infrared, Raman and NMR investigations of risedronate adsorption on nanocrystalline apatites

(2014) F. Errassifi et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Adsorption on apatitic calcium phosphates for drug delivery: interaction with bisphosphonate molecules

(2014) P. Pascaud et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Surface properties of biomimetic nanocrystalline apatites; applications in biomaterials

(2014) Christian Rey et al.   PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION OF MATERIALS

Surface modification of calcium hydroxyapatite by grafting of etidronic acid

(2013) Masseoud Othmani et al.   APPLIED SURFACE SCIENCE

Serum calcium and phosphate concentrations and intracranial atherosclerosis

(2013) K. Kang   ATHEROSCLEROSIS

Bisphosphonate-functionalized gold nanoparticles for contrast-enhanced X-ray detection of breast microcalcifications

(2013) Lisa E. Cole et al.   BIOMATERIALS

Microcalcifications in breast cancer: Lessons from physiological mineralization

(2013) Rachel F. Cox et al.   BONE

Thermodynamics of HEDPA protonation in different media and complex formation with Mg2+ and Ca2+

(2013) Claudia Foti et al.   JOURNAL OF CHEMICAL THERMODYNAMICS

Interaction between a Bisphosphonate, Tiludronate, and Biomimetic Nanocrystalline Apatites

(2013) Patricia Pascaud et al.   LANGMUIR

Poly[aqua[μ3-(pyridin-1-ium-3,5-diyl)diphosphonato-κ3O:O′:O′′][μ2-(pyridin-1-ium-3,5-diyl)diphosphonato-κ2O:O′]calcium(II)]

(2012) Magdalena Wilk et al.   ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS

Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits

(2012) John Turek et al.   CALCIFIED TISSUE INTERNATIONAL

Benefits and Risks of Bisphosphonate Therapy for Osteoporosis

(2012) Sundeep Khosla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Time Course of Zoledronate Interaction with Hydroxyapatite Nanocrystals

(2012) Elisa Boanini et al.   Journal of Physical Chemistry C

The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro

(2011) Elisa Boanini et al.   BIOMATERIALS

Bisphosphonates in oncology

(2011) Robert E. Coleman et al.   BONE

The relationship between the chemistry and biological activity of the bisphosphonates

(2011) Frank H. Ebetino et al.   BONE

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

The kidney and bisphosphonates

(2011) Paul D. Miller   BONE

Phosphonates, their complexes and bio-applications: A spectrum of surprising diversity

(2011) Joanna Galezowska et al.   COORDINATION CHEMISTRY REVIEWS

Atrial fibrillation and bisphosphonate therapy

(2011) Michael Pazianas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NMR, potentiometric and ESI-MS combined studies on the zinc(II) magnesium(II) and calcium(II) complexation by (morpholin-1-yl)methane-1,1-diphosphonic acid and its thio-analog

(2011) Ewa Matczak-Jon et al.   POLYHEDRON

The Bone Scan

(2011) Arnold I. Brenner et al.   SEMINARS IN NUCLEAR MEDICINE

Medical Potentialities of Biomimetic Apatites through Adsorption, Ionic Substitution, and Mineral/Organic Associations: Three Illustrative Examples

(2010) Ahmed Al-Kattan et al.   ADVANCED ENGINEERING MATERIALS

An in vitro Assay to Measure Targeted Drug Delivery to Bone Mineral

(2010) Wolfgang Jahnke et al.   ChemMedChem

Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group

(2010) Ermond van Beek et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Preclinical pharmacology of CGP 42′446, a new, potent, heterocyclic bisphosphonate compound

(2010) Jonathan R. Green et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases

(2010) O. Filleul et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Natural-Abundance43Ca Solid-State NMR Spectroscopy of Bone

(2010) Jiadi Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoporous surface of organofunctionalized hydroxyapatite fabricated from natural phosphate rock

(2010) S. Saoiabi et al.   MATERIALS LETTERS

Osteonecrosis of the Jaw and the Role of Bisphosphonates: A Critical Review

(2009) Stuart L. Silverman et al.   AMERICAN JOURNAL OF MEDICINE

Biofunctional alendronate–Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation

(2009) Adriana Bigi et al.   BIOMATERIALS

Specificity of the zinc(ii), magnesium(ii) and calcium(ii) complexation by (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related 1,3-(thiazol-2-yl) and 1,3-(benzothiazol-2-yl) derivatives

(2009) Ewa Matczak-Jon et al.   DALTON TRANSACTIONS

Differences between bisphosphonates in binding affinities for hydroxyapatite

(2009) M. A. Lawson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model

(2009) Sujoy Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

(2009) Yonghui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bisphosphonates: Mechanism of Action and Role in Clinical Practice

(2009) Matthew T. Drake et al.   MAYO CLINIC PROCEEDINGS

Bisphosphonates and Osteonecrosis: Potential Treatment or Serious Complication?

(2009) Robin N. Goytia et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Towards a new attenuating compound: A potentiometric, spectrophotometric and NMR equilibrium study on Fe(III), Al(III) and a new tetradentate mixed bisphosphonate–hydroxypyridinonate ligand

(2008) Guido Crisponi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Alendronate and Pamidronate calcium phosphate bone cements: Setting properties and in vitro response of osteoblast and osteoclast cells

(2008) S PANZAVOLTA et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ab initio structure determination of anhydrous sodium alendronate from laboratory powder X-ray diffraction data

(2008) Minakshi Asnani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

NMR Investigations of the Static and Dynamic Structures of Bisphosphonates on Human Bone:  a Molecular Model

(2008) Sujoy Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complexes of DOTA−Bisphosphonate Conjugates:  Probes for Determination of Adsorption Capacity and Affinity Constants of Hydroxyapatite

(2008) Tomáš Vitha et al.   LANGMUIR

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

(2008) R. G. G. Russell et al.   OSTEOPOROSIS INTERNATIONAL

Alendronate–hydroxyapatite nanocomposites and their interaction with osteoclasts and osteoblast-like cells

(2007) E BOANINI et al.   BIOMATERIALS

Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolutionin vitro

(2007) Zachary J. Henneman et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Interconvertable Modular Framework and Layered Lanthanide(III)-Etidronic Acid Coordination Polymers

(2007) F. N. Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY