Application of Mono- and Disaccharides in Drug Targeting and Efficacy

Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency

(2018) Armond Daci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bimodal Targeting Using Sulfonated, Mannosylated PEI for Combined Gene Delivery and Photodynamic Therapy

(2017) Upendra Chitgupi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Combretastatin A4-β-Galactosyl Conjugates for Ovarian Cancer Prodrug Monotherapy

(2017) Tomohiro Doura et al.   ACS Medicinal Chemistry Letters

Development of Sialic Acid-coated Nanoparticles for Targeting Cancer and Efficient Evasion of the Immune System

(2017) Young-Hwa Kim et al.   Theranostics

Towards understanding the role of sialylation in melanoma progression

(2016) Ewa Kolasińska et al.   ACTA BIOCHIMICA POLONICA

A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

(2016) Malay Patra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

(2016) Wen-Lian Chen et al.   CANCER CELL

Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics

(2016) Neeraj K. Garg et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

(2016) Qingpeng Wang et al.   DALTON TRANSACTIONS

Front cover

(2016)   DALTON TRANSACTIONS

Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer

(2016) Meng Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo

(2016) Malay Patra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells

(2016) Chuan Yang et al.   Advanced Healthcare Materials

Synthesis of Mannose-Cholesterol Conjugates for Targeted Liposomal Drug Delivery

(2016) Huong Nguyen et al.   ChemistrySelect

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells

(2016) Yutaka Okagawa et al.   PLoS One

Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and Its Disaccharide

(2015) Zhiqiang Yu et al.   BIOCHEMISTRY

Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems

(2015) Akiharu Ueki et al.   CARBOHYDRATE RESEARCH

Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action

(2015) Hong Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and syntheses of hyaluronan oligosaccharide conjugates as inhibitors of CD44-Hyaluronan binding

(2015) Xiaowei Lu et al.   GLYCOCONJUGATE JOURNAL

Sialic acids: biomarkers in endocrinal cancers

(2015) Shyamasree Ghosh   GLYCOCONJUGATE JOURNAL

Mannosylated Polyion Complexes for In Vivo Gene Delivery into CD11c+ Dendritic Cells

(2015) Lior Raviv et al.   MOLECULAR PHARMACEUTICS

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Abstract 4463: Targeting SN38 delivery to gastrointestinal cancer cells using a fucose-bound nanoparticle approach

(2015) Junji Kato et al.   CANCER RESEARCH

Design and Evaluation of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugates as Antigen-Presenting Cell-Selective siRNA Carriers

(2014) Keiichi Motoyama et al.   AAPS Journal

The Carbamoylmannose Moiety of Bleomycin Mediates Selective Tumor Cell Targeting

(2014) Chandrabali Bhattacharya et al.   BIOCHEMISTRY

Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting

(2014) Manikandadas M. Madathil et al.   BIOCHEMISTRY

A mannosylated cell-penetrating peptide-graft-polyethylenimine as a gene delivery vector

(2014) Ying Hu et al.   BIOMATERIALS

Escherichia coli β-galactosidase-catalyzed synthesis of 2-phenoxyethanol galactoside and its characterization

(2014) Kyung-Hwan Jung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity

(2014) Nitin S. Nandurkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells

(2014) Benjamin R. Schroeder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

(2014) Sonja I. Gringhuis et al.   Nature Communications

Synthesis of Mannosylated Polyethylenimine and Its Potential Application as Cell-Targeting Non-Viral Vector for Gene Therapy

(2014) Ying Hu et al.   Polymers

Targeted Cancer Therapy with a 2-Deoxyglucose-Based Adriamycin Complex

(2013) J. Cao et al.   CANCER RESEARCH

Highly water-soluble platinum(ii) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties

(2013) Pengxing Liu et al.   CHEMICAL COMMUNICATIONS

2-Deoxyglucose treatment complements the cisplatin- or BH3-only mimetic-induced suppression of neuroblastoma cell growth

(2013) Jiin-Haur Chuang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Novel Composed Galactosylated Nanodevices Containing a Ribavirin Prodrug as Hepatic Cell-Targeted Carriers for HCV Treatment

(2013) Emanuela Fabiola Craparo et al.   Journal of Biomedical Nanotechnology

Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers

(2013) Suzanne M. D'Addio et al.   JOURNAL OF CONTROLLED RELEASE

Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth

(2013) C. Bull et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of a Liver-Targeting Gold-PEG-Galactose Nanoparticle Platform and a Structure-Function Study

(2013) Ya Ding et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization

(2012) Hsiao-Wen Wang et al.   Acta Biomaterialia

Mannosylated Polyethyleneimine–Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines

(2012) Sunil Mahor et al.   BIOCONJUGATE CHEMISTRY

Effective Targeted Gene Delivery to Dendritic Cells via Synergetic Interaction of Mannosylated Lipid with DOPE and BCAT

(2012) Hee-Kwon Kim et al.   BIOMACROMOLECULES

Mannosylated biodegradable polyethyleneimine for targeted DNA delivery to dendritic cells

(2012) Xun Sun et al.   International Journal of Nanomedicine

Mannosylated liposomes for targeted gene delivery

(2012) Fansheng Kong et al.   International Journal of Nanomedicine

Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration

(2012) Jhon Alberto Ochoa-Alvarez et al.   PLoS One

A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells

(2011) Sara Spjut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High affinity sialoside ligands of myelin associated glycoprotein

(2011) Ying Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT

(2011) Lutz F. Tietze et al.   CHEMISTRY-A EUROPEAN JOURNAL

Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT

(2011) Lutz F. Tietze et al.   CURRENT PHARMACEUTICAL DESIGN

D-Galactose as a Vector for Prodrug Design

(2011) Daniela Melisi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs

(2011) Pierre Daumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The galactosylation of Nω-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice

(2011) Catia Giordano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Asymmetric Enzymatic Glycosylation of Mitoxantrone

(2011) Maoquan Zhou et al.   ORGANIC LETTERS

Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein

(2010) Oliver Schwardt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer

(2010) Makoto Matsui et al.   CANCER SCIENCE

Targeting with oligomannose-coated liposomes promotes maturation and splenic trafficking of dendritic cells in the peritoneal cavity

(2010) Mariko Ishii et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug

(2010) Ashay Jain et al.   JOURNAL OF CONTROLLED RELEASE

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

(2010) Emma C Nilsson et al.   NATURE MEDICINE

Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents

(2009) Elisabeth Miot-Noirault et al.   INVESTIGATIONAL NEW DRUGS

Galactosyl derivative ofNω-nitro-L-arginine: Study of antiproliferative activity on human thyroid follicular carcinoma cells

(2009) Daniela Melisi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation

(2009) Wassana Wijagkanalan et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery

(2009) Qian Chen et al.   JOURNAL OF DRUG TARGETING

Galactosyl Prodrug of Ketorolac: Synthesis, Stability, and Pharmacological and Pharmacokinetic Evaluations

(2009) Annalisa Curcio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myelin-associated glycoprotein and its axonal receptors

(2009) Ronald L. Schnaar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Carbohydrate Dependent Targeting of Cancer Cells by Bleomycin−Microbubble Conjugates

(2009) Jean-Charles Chapuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Antitumor Activity of Novel Water-Soluble Taxoids

(2008) Katsuhiko Mikuni et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Galactosylated fluorescent labeled micelles as a liver targeting drug carrier

(2008) De-Qun Wu et al.   BIOMATERIALS

Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives

(2008) Bastien Reux et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of d-galactose-β-cyclodextrin conjugates as drug-carrying molecules

(2008) Yoshiki Oda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

(2008) Ian Cumpstey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicityin vitro andin vivo

(2008) Kuo-Ching Sheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mannose-targeted systems for the delivery of therapeutics

(2008) Juan M Irache et al.   Expert Opinion on Drug Delivery

Synthesis and properties of a novel methoxy poly(ethylene glycol)-modified galactosylated chitosan derivative

(2008) Tao Zhang et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Mannosylated Cationic Liposomes/CpG DNA Complex for the Treatment of Hepatic Metastasis after Intravenous Administration in Mice

(2008) Yukari Kuramoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identification and Development of Fucosylated Glycoproteins as Biomarkers of Primary Hepatocellular Carcinoma

(2008) Mary Ann Comunale et al.   JOURNAL OF PROTEOME RESEARCH

Mannosylated gelatin nanoparticles bearing an anti-HIV drug didanosine for site-specific delivery

(2008) Sanjay K. Jain et al.   Nanomedicine-Nanotechnology Biology and Medicine

Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice

(2007) L RUOCCO et al.   BEHAVIOURAL BRAIN RESEARCH

Galactosylated dopamine enters into the brain, blocks the mesocorticolimbic system and modulates activity and scanning time in Naples high excitability rats

(2007) L.A. Ruocco et al.   NEUROSCIENCE